A multinational study demonstrated that temperature response to dosage of activity is different between subjects with acute Charcot neuroarthropathy (CN) and age matched non-CN with type 2 diabetes and peripheral neuropathy. Twenty-two eligible subjects were enrolled in this study. The plantar temperature response to walking for two predefined paths of 50 and 150 steps was examined. The results demonstrate that the proposed stress test allows differentiating CN with higher effect size than static plantar temperature assessment.
‘The observed differential thermal response to walking initiation between Charcot and non-Charcot feet warrants future investigation to provide further insight into the correlation between activity dosing and thermal response’, said Dr Najafi, lead author and Associate professor at the department of surgery, Southern Arizona Limb Salvage Alliance (SALSA), University of Arizona. ‘It may also led valuable insight into identifying an “inflammatory trigger” that may ultimately provide an early warning sign or increased sensitivity for subsequent unilateral or bilateral CN development or clinical expression of foot ulcer’, he added. This study has been published at the Journal of Aging Research.