How wounds become chronic based on interactions with bacteria- and how to target this phenomenon

Superb work from Versey et al. We summarize it in this .gif The first series shows the contribution of innace wound cells to chronicity based on the four phases of healing. The second shows potential targets throughout these phases.

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@CDCgov Analysis of Cost Effectiveness in #Diabetes: Hypertension Control and Foot Care top the list @alpslimb #DiabeticFoot #ActAgainstAmputation @apma

This superb report from Siegel and coworkers from the Centers for Disease Control and Prevention. OBJECTIVE To synthesize updated evidence on the cost-effectiveness (CE) of interventions to manage diabetes, its complications, and comorbidities. RESEARCH DESIGN AND METHODS We conducted a systematic literature review of studies from high-income countries evaluating the CE of diabetes management interventions recommended by […]

Read More @CDCgov Analysis of Cost Effectiveness in #Diabetes: Hypertension Control and Foot Care top the list @alpslimb #DiabeticFoot #ActAgainstAmputation @apma

Topical Oxygen and Wound Healing? Results from a systematic review and meta analysis

Data continue to accumulate for some role of topical oxygen in tissue repair and wound healing. This study from vascular surgeon Jonathan Golledge’s team at JCU in Australia. Abstract Introduction: Topical oxygen therapy (TOT) has been suggested as a treatment for diabetes- related foot ulcer (DFU) but no prior meta-analyses of randomised clinical trials (RCT) have […]

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The Degree of Blood Supply and Infection Control Needed to Treat Diabetic Chronic Limb-Threatening Ischemia with Forefoot Osteomyelitis @USC_Vascular @JAPMAFeetTweets

untitled Miki Fujii, MD, PhD* Hiroto Terashi, MD, PhD† Koichi Yokono, MD, PhD‡ David G. Armstrong, DPM, MD, PhD§ Background: Diabetic foot ulcers combined with ischemia and infection can be difficult to treat. Few studies have quantified the level of blood supply and infection control required to treat such complex diabetic foot ulcers. We aimed […]

Read More The Degree of Blood Supply and Infection Control Needed to Treat Diabetic Chronic Limb-Threatening Ischemia with Forefoot Osteomyelitis @USC_Vascular @JAPMAFeetTweets

Armstrong Keynotes International Foot and Ankle Biomechanics (#iFAB2021) symposium from Rancho Los Amigos @RanchoRehab RanchoResearchI @KeckMedUSC @USC_Vascular @USC

David G. Armstrong, Professor of Surgery at the Keck School of Medicine of University of Southern California joined physicians, surgeons, engineers and scientists from around the world for the International Foot and Ankle Biomechanics conference. Originally scheduled for Rio De Janiero, Brazil in April of 2020 and chaired by Prof. Isabelle Sacco, the symposium- known […]

Read More Armstrong Keynotes International Foot and Ankle Biomechanics (#iFAB2021) symposium from Rancho Los Amigos @RanchoRehab RanchoResearchI @KeckMedUSC @USC_Vascular @USC

Long-term followup of conservative management of Charcot feet – 93% amputation-free survival at 5 years

Excellent work from our friends and colleagues at the Balgrist in Zurich. Abstract Background: Charcot arthropathy (CN) can ultimately lead to limb loss despite appropriate treatment. Initial conservative treatment is the accepted treatment in case of a plantigrade foot. The aim of this retrospective study was to investigate the mid- to long-term clinical course of CN […]

Read More Long-term followup of conservative management of Charcot feet – 93% amputation-free survival at 5 years

Effect of High-frequency Spinal Cord Stimulation in Patients With Painful Diabetic #Neuropathy: A Randomized Clinical Trial @JAMANeuro

Intriguing report from Petersen and coworkers for a common, complex and costly condition. Importance  Many patients with diabetic peripheral neuropathy experience chronic pain and inadequate relief despite best available medical treatments. Objective  To determine whether 10-kHz spinal cord stimulation (SCS) improves outcomes for patients with refractory painful diabetic neuropathy (PDN). Design, Setting, and Participants  The prospective, multicenter, open-label […]

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Scientists connect human brain to computer wirelessly for first time ever

Via the Independent: The first wireless commands to a computer have been demonstrated in a breakthrough for people with paralysis. The system is able to transmit brain signals at “single-neuron resolution and in full broadband fidelity”, say researchers at Brown University in the US. A clinical trial of the BrainGate technology involved a small transmitter […]

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