Absence of Evidence or Evidence of Absence? @SennevilleEric and Ben Lipsky on Bone Biopsy in Diabetic Foot Osteomyelitis #DFO #osteomyelitis #DFU #DFI #ActAgainstAmputation

Senneville and Lipsky return with a measured rejoinder in Clinical Infectious Diseases (April 2026), arguing that the Lagrand trial shows the absence of evidence of superiority — not definitive equivalence — between ulcer-bed and bone biopsy for guiding antibiotic therapy in diabetic foot osteomyelitis.

Outcomes of short versus long duration of antibiotic therapy for residual osteomyelitis in surgically resected diabetic foot infection #ActAgainstAmputation @ALPSlimb

More data (this report from Motaganahalli and coworkers to support the likely contention that, in general, shorter may be better - or at very least not worse. Introduction: Optimal treatment duration for residual osteomyelitis (OM) post-amputation in diabetic foot infection (DFI) remains unclear, with resultant heterogeneity in prescribing noted in clinical practice. We aimed to identify... Continue Reading →

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