On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
An email from Ben Lipsky brings new biomarker data — IL-17, IL-12p70, HMGB1, IL-8, CRP — that may be the strongest case yet for splitting "moderate" and "severe" diabetic foot infections in the IDSA and WIfI classification.
A novel inflammation-nutrition biomarker — the neutrophil percentage-to-albumin ratio (NPAR) — shows strong association with diabetic foot ulcer risk in a 1,002-patient study from Xi'an, China, reinforcing that what patients eat and how they inflame are inseparable in the diabetic foot.
Diabetic foot infections (DFIs) are a critical concern for individuals with diabetes, often leading to severe complications and increased healthcare costs. A recent meta-analysis by Yu-Ting Wang and colleagues, published in the journal Wounds in December 2023, sheds light on the role of inflammatory markers in detecting DFIs, which could pave the way for improved... Continue Reading →
In a recent study by Coye et al. (2023), with many of long-time SALSAmigos as coauthors , the effectiveness of C-reactive protein (CRP)/albumin, erythrocyte sedimentation rate (ESR)/albumin ratio, ESR, CRP, and albumin were evaluated to differentiate bone and soft tissue infection in persons with diabetes[1]. The study retrospectively evaluated 242 individuals admitted to the hospital... Continue Reading →
The manuscript offers a nuanced examination of how biomarkers like CXCL5, SERPINB3, and Neutrophil Elastase can foretell the healing trajectory of diabetic foot ulcers (DFUs). It synthesizes data from multiple clinical studies, underscoring that a high level of CXCL5 correlates with non-healing ulcers, while decreased SERPINB3 levels indicate a quicker healing process. Such insights could... Continue Reading →
An excellent contribution to the literature from Bobirca and coworkers from Bucharest. Abstract Background: Although Charcot diabetic foot (CDF) is a frequent complication of diabetic neuropathy, less is known about the possibility of its early prevention. Methods: A review of the original articles published in English, using the “biomarkers AND Charcot’s foot” criterion, resulted in 33... Continue Reading →
Here is more cogent information to support the contention that we might consider adding bacteria rather than just removing it. To (again) use a military analogy, what one might describe as "clear, hold, and build" rather than just "clear". A Review of Immunomodulatory Reprogramming by Probiotics in Combating Chronic and Acute Diabetic Foot Ulcers (DFUs)... Continue Reading →
This from Rong and coworkers Summary Points: Diabetic foot ulcer (DFU) is a complex and devastating complication of diabetes mellitus that are usually stagnant in the inflammatory phase.However, oral wound healing, which is characterized by a rapid and scarless healing process, is regarded an ideal model of wound healing.Thus, we performed a comprehensive bioinformatics analysis... Continue Reading →
