On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
Senneville and Lipsky return with a measured rejoinder in Clinical Infectious Diseases (April 2026), arguing that the Lagrand trial shows the absence of evidence of superiority — not definitive equivalence — between ulcer-bed and bone biopsy for guiding antibiotic therapy in diabetic foot osteomyelitis.
Friends, we have some serious dogma-busting data to discuss today. For as long as most of us have been in the limb salvage game, the percutaneous bone biopsy has been preached as the absolute "Gold Standard" for guiding antibiotic therapy in Diabetic Foot Osteomyelitis (DFO). The logic was sound: if you want to know what’s... Continue Reading →
Understanding the Molecular Landscape of Chronic Cutaneous Wounds Chronic cutaneous wounds are a significant burden on healthcare systems worldwide, affecting millions of individuals and posing a challenge for medical research and patient care. A recent study by Richards et al. (2024) has provided additional insights into the molecular mechanisms underlying various common chronic ulcer types... Continue Reading →
Strong work from Bradbury and coworkers in the IWJ. Bottom line: Both swabs and tissues appeared to perform well for 16s sampling and sequencing. Identifying the microbiome within chronic diabetic foot ulcers is essential if effective antimicrobial therapies are to be administered. Using culture and 16S rRNA gene sequencing, the aim of this study was... Continue Reading →
Generalized description of MicroRNAs Zhao and coworkers continue strengthening the research toward companion diagnostics with these strong data supporting assessing micro-RNA 103 (miRNA 103) levels in tissue margins. Changes in miroRNA103 expression in wound margin tissue are related to wound healing of diabetes foot ulcers Key Messages microRNAs (miRNAs) are involved in the regulation of... Continue Reading →
