Exciting new data from our friend and colleague Ben Lipsky and his team highlights a potential shift in how we approach one of our most stubborn challenges: Staphylococcus aureus (StA) in diabetic foot osteomyelitis (DFO). Current standards of care for DFO are often unsatisfactory. This Phase 2, randomized, double-blind, placebo-controlled trial investigated BX211, a personalized... Continue Reading →
Dysregulation of Wnt signaling in bone of type 2 diabetes mellitus and diabetic Charcot arthropathy @ALPSlimb #Charcot #ActAgainstAmputation
Gassel and coworkers report DOWNREGULATION of WNT signaling in Charcot Arthropathy published in BMC Musculoskeletal Disorders Background Type 2 diabetes mellitus (T2DM) patients show a markedly higher fracture risk and impaired fracture healing when compared to non-diabetic patients. However in contrast to type 1 diabetes mellitus, bone mineral density in T2DM is known to be... Continue Reading →
Application and Clinical Effectiveness of Antibiotic-Loaded Bone Cement in the Treatment of Neuropathic Diabetic Foot Ulcers Complicated by Osteomyelitis: A Randomized Controlled Trial
Intriguing work by Ehya and coworkers. Abstract This study explored the clinical effectiveness of antibiotic-loaded bone cement on primary treatment of diabetic foot infection. This is a randomized controlled study, including thirty-six patients with diabetic foot ulcer complicated by osteomyelitis who had undergone treatment between May 2018 and December 2019. Patients were randomly divided into... Continue Reading →
Use of 3D Printed Artificial Bone
Animal Testing on Biodegradable 3D Printed Artificial Bone Successfully Accomplished in Xiโan, China - 3DPrint.com. This is logical low-hanging fruit for 3D printing.ย Rigid matrices like bone that can accept human cellular ingrowth. Terrific? We think so.