On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
When we talk about Chronic Limb-Threatening Ischemia (CLTI), we often focus on what we can see on an angiogram. But what is actually happening inside those vessels at a microscopic level? A comprehensive histopathological analysis of amputated limbs is shedding new light on the specific patterns of arterial obstruction that lead to limb loss. This... Continue Reading →
Screenshot Screenshot Screenshot Microsurgical limb salvage is one of the most complex, high-stakes interventions in modern reconstructive surgery. For patients with peripheral artery disease (PAD), the decision to proceed with free tissue transfer (FTT) is fraught with uncertainty—especially when calcified, fragile vessels may compromise flap viability from the outset. A new study by Felder and colleagues,... Continue Reading →
Congratulations to our combined UNC and USC team led by Kate McGinigle and Alex DiBartolomeo. This provides further data supporting the use of medial arterial calcification (MAC) score as a useful surrogate for risk. Alexander D DiBartolomeo 1, Sydney E Browder 2, Sebouh Bazikian 1, Diwash Thapa 2, Sooyeon Kim 2, Avital Yohann 2, David... Continue Reading →
pMAC / Pedal Medial Arterial Calcification Score Yet more important work from our Toe- and Flowmigos @ UCSF. Objective: Pedal medial arterial calcification (pMAC) is associated with major amputation in patients with chronic limb-threatening ischemia (CLTI). We hypothesize that this association would be related to unresolved distal ischemia. We investigated relationships across pMAC score, hemodynamic change,... Continue Reading →
Make the link between chronic kidney disease, pedal calcification...and even Charcot? This from our SALSAmigos at Washington University, St. Louis. Aims: Determine the prevalence and relative risk of having single and combinations of biomarkers of chronic kidney disease-mineral bone disorder (CKD-MBD) syndrome in the diabetic foot from an electronic medical record (EMR) review. Methods: Review of 152... Continue Reading →
Important work from our long-time friends Luigi Uccioli and coworkers. Some, including our friend Elissa Altin of Yale, have suggested that this might lead to us getting radiographs to identify arterial calcification that could help identify PAD, CLTI and even CAD. What do you think? Aim: The aim of the current study is to evaluate the... Continue Reading →
