Tag: companion diagnostics

Imagine: A Smart Reactive Hydrogel To Revolutionize Diabetic Wound Healing #MMP9 #Inflammation #CompanionDiagnostic #ActAgainstAmputation

Diabetic wounds present one of the most complex and persistent challenges in modern medicine, often leading to prolonged inflammation and impaired healing. A recent study by Meng et al. (2025) introduces a potentially groundbreaking solution: a smart, MMP-9-responsive hydrogel that releases M2 macrophage-derived exosomes (M2-Exos) in response to the inflammatory microenvironment of diabetic wounds. This innovation has the potential... Continue Reading →

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The effect of inflammation management on pH, temperature, and bacterial burden #ActAgainstAmputation #WoundHealing

Important work from Derwin and coworkers in Zena Moore's group. The aim of this feasibility study was to investigate the impact of inflammation management on wound pH, temperature, and bacterial burden, using the principles of TIME and Wound Bed Preparation. A quantitative non-comparative, prospective, descriptive observational design. Following ethical approval, 26 participants with 27 wounds... Continue Reading →

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The Use of Point-of Care Bacterial Autofluorescence Imaging in the Management of Diabetic Foot Ulcers: A Pilot Randomized Controlled Trial #Diagnostics #Theragnostics

Important work from our SALSAmigos in Leeds. We see a slow and steady march toward companion diagnostics for our patients. Here we see fluorescence-guided debridement as an example of this. OBJECTIVE To estimate comparative healing rates and decision-making associated with the use of bacterial autofluorescence imaging in the management of diabetic foot ulcers (DFUs). RESEARCH... Continue Reading →

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Bacterial Protease Activity (BPA) may reduce Hospitalization, Improve Quality of LIfe: RCT #Theragnostics #Diagnostics #ActAgainstAmputation

This published in the Journal of Wound Care Effectiveness of testing hard-to-heal wounds for bacterial protease activity: a randomised clinical trial The rapid lateral flow test for BPA is easy to perform, provides actionable results at the point-of-care, and is a useful diagnostic tool to assist wound care clinicians in evidence-based treatment decisions

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