Evaluation of Glycologic Point-of-Care Infection Test Kit for Diabetic Foot Ulcers in Relation to Bacterial Presence: A Prospective Cohort Study #ActAgainstAmputation @JAPMAfeettweets

This from our colleagues in Carlisle, UK. We see more chairside/bedside diagnostics and theragnostics to help measure what we manage. Background: Point-of-care testing for infection might help podiatric physicians optimize management of diabetic foot ulcers (DFUs). Glycologic's proprietary GLYWD product has been developed to detect changes in a patient's immunologic/inflammatory response related to wound infection. We... Continue Reading →

Routine bacterial culture of proximal bone specimens during minor amputation in patients with DFI has little clinical utility in predicting re-operation or healing @ALPSlimb #ActAgainstAmputation #DiabeticFoot

Bone cultures? Clean margins for pathology? Both? These data from Voon and colleagues add more fuel to the discussionBackground: Trans-phalangeal and trans-metatarsal amputation, collectively termed 'minor amputations' are important procedures for managing infections of diabetes-related foot ulcers (DFU). Following minor amputation, international guidelines recommend a prolonged course of antibiotics if residual infected bone on intra-operative... Continue Reading →

Transcriptomic Fingerprint of Bacterial Infection in Lower Extremity Ulcers @ALPSLimb #ActAgainstAmputation

Important work from our Danish and Aussie colleagues Abstract Background and purpose: Clinicians and researchers utilize subjective, clinical classification systems to stratify lower extremity ulcer infections for treatment and research. The purpose of this study was to examine whether these clinical classifications are reflected in the ulcer's transcriptome. Methods: RNA-sequencing (RNA-seq) was performed on biopsies from clinically... Continue Reading →

Automated Detection of Infection in Diabetic Foot Ulcer Images #AI #DeepLearning #MachineLearning #C2SHiPUsing Convolutional Neural Network

More work supporting the ongoing efforts to create a deep learning/AI model to assist in diagnosis of diabetic foot ulcer/wound healing images J Yogapriya 1, Venkatesan Chandran 2, M G Sumithra 3, B Elakkiya 4, A Shamila Ebenezer 5, C Suresh Gnana Dhas 6 A bacterial or bone infection in the feet causes diabetic foot infection (DFI), which results in reddish skin in the wound and... Continue Reading →

The microbiology of diabetic foot infections: a meta-analysis

The microbiology of diabetic foot infections: a meta-analysisExcellent work from MacDonald and coworkers from Edinburgh. The microbiology of diabetic foot infections: a meta-analysis Background: Diabetic foot ulcers are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. There have been numerous studies of the microbiology of diabetic foot infec-... Continue Reading →

Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay

Excellent work in diagnostics and theragnostics from Brunauer and coworkers in the journal Biosensors. Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay Abstract: The rapid detection of pathogens in infected wounds can significantly improve the clinical outcome. Wound exudate, which can be collected in a non-invasive way, offers an attractive... Continue Reading →

Can probiotics improve healing of diabetic foot ulcers? Results from a randomized controlled trial

This fascinating work from Mohseni and coworkers seems to support the contention that our bacterial overlords have more power over us than we'd like to let on. Perhaps we should further consider submitting? Patients with a diabetic foot ulcer who received probiotic supplementation for 12 weeks experienced faster wound healing coupled with an improved glycemic... Continue Reading →

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