On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
Harnessing Probiotics: A Leap Towards Alleviating Diabetic Foot Infections In the battle against diabetic foot infections, a beacon of hope emerges from the heart of Baghdad. A recent manuscript published in the Iraqi Journal of Science, penned by Haneen Majid Abdulkareem AlAsadi and Khalid Jaber Kadhum Luti from the Department of Biotechnology, College of Science,... Continue Reading →
This from our sister unit at Zurich's The Balgrist along with one of our longest-standing SALSAmigos, Prof. Ben Lipsky. Abstract Aim To retrospectively evaluate clinical and microbiological outcomes after combined surgical and medical therapy for diabetic foot infections (DFIs), stratifying between the empirical versus the targeted nature, and between an empirical broad versus a narrow-spectrum,... Continue Reading →
This from our colleagues in Carlisle, UK. We see more chairside/bedside diagnostics and theragnostics to help measure what we manage. Background: Point-of-care testing for infection might help podiatric physicians optimize management of diabetic foot ulcers (DFUs). Glycologic's proprietary GLYWD product has been developed to detect changes in a patient's immunologic/inflammatory response related to wound infection. We... Continue Reading →
Bone cultures? Clean margins for pathology? Both? These data from Voon and colleagues add more fuel to the discussionBackground: Trans-phalangeal and trans-metatarsal amputation, collectively termed 'minor amputations' are important procedures for managing infections of diabetes-related foot ulcers (DFU). Following minor amputation, international guidelines recommend a prolonged course of antibiotics if residual infected bone on intra-operative... Continue Reading →
Important work from our Danish and Aussie colleagues Abstract Background and purpose: Clinicians and researchers utilize subjective, clinical classification systems to stratify lower extremity ulcer infections for treatment and research. The purpose of this study was to examine whether these clinical classifications are reflected in the ulcer's transcriptome. Methods: RNA-sequencing (RNA-seq) was performed on biopsies from clinically... Continue Reading →
More work supporting the ongoing efforts to create a deep learning/AI model to assist in diagnosis of diabetic foot ulcer/wound healing images J Yogapriya 1, Venkatesan Chandran 2, M G Sumithra 3, B Elakkiya 4, A Shamila Ebenezer 5, C Suresh Gnana Dhas 6 A bacterial or bone infection in the feet causes diabetic foot infection (DFI), which results in reddish skin in the wound and... Continue Reading →
The microbiology of diabetic foot infections: a meta-analysisExcellent work from MacDonald and coworkers from Edinburgh. The microbiology of diabetic foot infections: a meta-analysis Background: Diabetic foot ulcers are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. There have been numerous studies of the microbiology of diabetic foot infec-... Continue Reading →
Excellent work in diagnostics and theragnostics from Brunauer and coworkers in the journal Biosensors. Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay Abstract: The rapid detection of pathogens in infected wounds can significantly improve the clinical outcome. Wound exudate, which can be collected in a non-invasive way, offers an attractive... Continue Reading →
This fascinating work from Mohseni and coworkers seems to support the contention that our bacterial overlords have more power over us than we'd like to let on. Perhaps we should further consider submitting? Patients with a diabetic foot ulcer who received probiotic supplementation for 12 weeks experienced faster wound healing coupled with an improved glycemic... Continue Reading →
