Etiology, Epidemiology, and Disparities in the Burden of Diabetic Foot Ulcers #ActAgainstAmputation @ALPSLimb @CaitlynWHicks @DiabetesCareADA

An important and comprehensive review from McDermott and coworkers at JHU and Prof. Boulton at Manchester. Diabetic foot ulcers (DFU) are a major source of preventable morbidity in adults with diabetes. Consequences of foot ulcers include decline in functional status, infection, hospitalization, lower-extremity amputation, and death. The lifetime risk of foot ulcer is 19% to... Continue Reading →

Use of Hyperspectral Imaging to Predict Healing of Diabetic Foot Ulceration #Diagnostics #Theragnostics #ActAgainstAmputation @ALPSlimb

This work by our colleagues from the Deaconess and Joslin constitutes another advance in the slow, steady march toward deriving an actionable value from hyperspectral imaging. Bottom line: Using oxyHb 50 as the cutof point to predict DFU complete healing, Visit 1 oxyHb measurement provided 85% sensitivity, 70% specificity, 50% positive predictive value and 93%... Continue Reading →

Granulocyte‐macrophage colony‐stimulating factor: Conductor of the wound healing orchestra? ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC @USC_vascular @ResearchatUSC @KeckSchool_USC

Granulocyte-macrophage colony-stimulating factor: Conductor of the wound healing orchestra? This manuscript from our team led by Karim Ead Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein and is derived from both hemopoietic and nonhemopoietic sources which exert immunomodulatory properties. Various theories have been proposed to explain why some wounds become chronic and non-healing. Generalized suppression of... Continue Reading →

Cost of Treatment of Neuroischemic Ulcers of the Lower Extremity in Patients with Peripheral Artery Disease in the United States ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC @USC_vascular @ResearchatUSC @KeckSchool_USC @JAPMAFeetTweets @APMA

This from our team USC and colleagues Paul Saatsoglou and Susan Pitman-Lowenthal. Bottom line: This study analyzed the cost of treating neuroischemic ulcers (a type of wound) on the lower extremities in patients with peripheral artery disease using medical and hospital claims records submitted for reimbursement to private insurance, Medicare, and Medicaid. The study population... Continue Reading →

Effects of vildagliptin on wound healing and markers of inflammation in patients with type 2 diabetic foot ulcer: a prospective, randomized, double-blind, placebo-controlled, single-center study #ActAgainstAmputation @ALPSlimb

From our colleagues at James Cook University in Queensland, Australia. Introduction: Diabetic foot ulcers (DFU) are one of the leading long-term complications experienced by patients with diabetes. Dipeptidyl Peptidase 4 inhibitors (DPP4is) are a class of antihyperglycemic medications prescribed to patients with diabetes to manage glycaemic control. DPP4is may also have a beneficial effect on DFU... Continue Reading →

Reliability of the evidence to guide decision-making in foot ulcer prevention in diabetes: an overview of systematic reviews

Excellent work from Fay Crawford and colleagues to highlight a glaring need in the literature: more data on primary prevention of diabetic foot ulcers. Background: Reliable evidence on the effectiveness of interventions to prevent diabetes-related foot ulceration is essential to inform clinical practice. Well-conducted systematic reviews that synthesise evidence from all relevant trials offer the most... Continue Reading →

Future Directions in Research in Transcriptomics in the Healing of Diabetic Foot Ulcers @alpslimb #ActAgainstAmputation #WoundHealing

Great work from our colleagues in Yale + Harvard Diabetic foot ulcers are a health crisis that affect millions of individuals worldwide. Current standard of care involves diligent wound care with adjunctive antibiotics and surgical debridement. However, despite this, the majority will still become infected and fail to heal. Recent efforts using bioengineered skin initially... Continue Reading →

Deriving ICD-9 and ICD-10 Codes For Identifying and Following Patients with Diabetic Lower Extremity Ulcers

Deriving ICD-9 and ICD-10 Codes For Identifying and Following Patients with Diabetic Lower Extremity Ulcers This from our collective team led by Xavier Fowler and Phil Goodney. Here's to helping measure what we manage-- especially via often opaque medical records. •Type of Research: Methodologic study for identifying clinical cohorts using Medicare claims data.•Key Findings: We identified 45... Continue Reading →

Two-Stage Gene Therapy (VEGF, HGF and ANG1 Plasmids) as Adjunctive Therapy in the Treatment of Critical Lower Limb Ischemia in Diabetic Foot Syndrome #ActAgainstAmputation #DiabeticFoot @ALPSlimb

It's superb work from our Polish colleagues. One of the most serious problems in people with diabetes is diabetic foot syndrome. Due to the peripheral location of atherosclerotic lesions in the arterial system of the lower extremities, endovascular treatment plays a dominant role. However, carrying out these procedures is not always possible and does not... Continue Reading →

Effects of Special Therapeutic Footwear on the Prevention of #DiabeticFoot Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials @ALPSlimb #ActAgainstAmputation

This manuscript from Luo and coworkers provides an update on one of the most important interventions we can provide our patients. Objective: To reduce diabetic foot ulcer (DFU) occurrence or recurrence, diabetic therapeutic footwear is widely recommended in clinical practice for at-risk patients. However, the effectiveness of therapeutic footwear is controversial. Thus, we performed a systematic... Continue Reading →

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