Do diabetes-related foot ulcer wound fluid measures have clinical utility as biomarkers for healing? A systematic review @ALPSlimb #ActAgainstAmputation

This work from Longfield and coworkers from Stephen Twigg's unit further highlight the potential benefit of measuring what we manage. Objective: This study aimed to identify potential biomarkers reported in wound fluid of diabetes-related foot ulcers (DRFUs), and their ability to reflect current and prospective wound healing. Method: A systematic search was executed following the PRISMA methodology... Continue Reading →

A Wearable Insole System to Measure Plantar Pressure and Shear for People with Diabetes #ActAgainstAmputation @alpslimb #DiabeticFoot

A Wearable Insole System to Measure Plantar Pressure and Shear for People with Diabetes As many know, shear stress has been notoriously difficult to measure in vivo. This is an important step (so to speak) toward addressing that. Great work from our Southampton, Newcastle, and Manchester brethren A Wearable Insole System to Measure Plantar Pressure... Continue Reading →

‘Smart’ Bandages Monitor Wounds and Provide Targeted Treatment @Caltech @USC ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC_vascular @ResearchatUSC @KeckSchool_USC

This release regarding a manuscript published by our combined Caltech/USC team led by our SALSAmigo, Wei Gao. Also see this from the Guardian newspaper. Summary: A recent study from Caltech and USC reports that smart bandages equipped with biosensors could significantly improve the healing process of chronic wounds. These high-tech bandages monitor wounds in real-time... Continue Reading →

Unmet needs in diabetes-related foot ulcer (DFU) treatment

Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes, affecting approximately 34% of people with the disease. Despite advancements in treatment, there are still several unmet needs in the care of diabetic foot ulcers that can lead to poor outcomes, including prolonged healing time, infection, hospitalization, and amputation. Some of the key... Continue Reading →

Three Blinded Adjudicators: Minimizing bias in a diabetic foot ulcer clinical evaluation

This three blinded adjudicator model is one we've been using for several years in recent RCTs. Congrats to our amigos Paul Glat, Lisa Gould, Lael Pickett, and Doug Arm for putting it out there for publication and ultimately iteration. This specific analysis was derived from the HIFLO trial. Summary: The article discusses the steps taken... Continue Reading →

Mechanisms of diabetic foot ulceration

Mechanisms of diabetic foot ulceration: A review Here's the summary of this manuscript by Deng and coworkers: • Diabetic foot ulcers (DFUs) are a serious complication of diabetes, with complex pathogenic factors. • Previous studies focused on diabetic peripheral vascular disease, neuropathy, and wound infections. • Researchers are now studying immune cells, endothelial cells, keratinocytes,... Continue Reading →

Level of 25-hydroxyvitamin D and vitamin D receptor in diabetic foot ulcer and factor associated with diabetic foot ulcers #ActAgainstAmputation @ALPSlimb

Tang and coworkers present these data. Bottom line: The study aimed to investigate the correlation between vitamin D deficiency and diabetic foot osteomyelitis (DFO) in patients with type 2 diabetes mellitus (T2DM) and diabetic foot ulcer (DFU). The levels of serum 25-hydroxyvitamin D [25(OH)VD] and vitamin D receptor (VDR) expression in wound margin tissues were... Continue Reading →

Sex differences in diabetic foot ulcer severity and outcome #ActAgainstAmputation @ALPSlimb #Belgium @PLoSOne #Location

We thank our Belgian colleagues for this enormously useful data. Bottom line: Sex differences play an important role in the epidemiology, treatment, and outcomes of many diseases. Men with diabetic foot ulcers (DFU) presented with more severe ulcers and had a higher prevalence of previous lower limb revascularization and smoking compared to women. Women with... Continue Reading →

Etiology, Epidemiology, and Disparities in the Burden of Diabetic Foot Ulcers #ActAgainstAmputation @ALPSLimb @CaitlynWHicks @DiabetesCareADA

An important and comprehensive review from McDermott and coworkers at JHU and Prof. Boulton at Manchester. Diabetic foot ulcers (DFU) are a major source of preventable morbidity in adults with diabetes. Consequences of foot ulcers include decline in functional status, infection, hospitalization, lower-extremity amputation, and death. The lifetime risk of foot ulcer is 19% to... Continue Reading →

Use of Hyperspectral Imaging to Predict Healing of Diabetic Foot Ulceration #Diagnostics #Theragnostics #ActAgainstAmputation @ALPSlimb

This work by our colleagues from the Deaconess and Joslin constitutes another advance in the slow, steady march toward deriving an actionable value from hyperspectral imaging. Bottom line: Using oxyHb 50 as the cutof point to predict DFU complete healing, Visit 1 oxyHb measurement provided 85% sensitivity, 70% specificity, 50% positive predictive value and 93%... Continue Reading →

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