Toward non-invasive collection methods for sampling the microbiome of diabetic foot ulcers #Infection #Diabetes #ActAgainstAmputation #DiabeticFoot

Strong work from Bradbury and coworkers in the IWJ. Bottom line: Both swabs and tissues appeared to perform well for 16s sampling and sequencing. Identifying the microbiome within chronic diabetic foot ulcers is essential if effective antimicrobial therapies are to be administered. Using culture and 16S rRNA gene sequencing, the aim of this study was... Continue Reading →

Diabetic Foot Ulcer Imaging: An Overview and Future Directions #C2SHiP #ActAgainstAmputation #Imaging #Diabetes #DiabeticFoot #Diagnostics

This from our combined team from FIU, UCSF, and USC led by Anu Godavarty Diabetic foot ulcers (DFUs) affect one in every three people with diabetes. Imaging plays a vital role in objectively complementing the gold-standard visual yet subjective clinical assessments of DFUs during the wound treatment process. Herein, an overview of the various imaging... Continue Reading →

Do diabetes-related foot ulcer wound fluid measures have clinical utility as biomarkers for healing? A systematic review @ALPSlimb #ActAgainstAmputation

This work from Longfield and coworkers from Stephen Twigg's unit further highlight the potential benefit of measuring what we manage. Objective: This study aimed to identify potential biomarkers reported in wound fluid of diabetes-related foot ulcers (DRFUs), and their ability to reflect current and prospective wound healing. Method: A systematic search was executed following the PRISMA methodology... Continue Reading →

Wound pH and Surface Temperature as a Predictive Biomarker of Healing in Diabetic Foot Ulcers #Diagnostic #Theragnostic #Thermometry #ActAgainstAmputation @ALPSLIMB

More supportive literature surround inflammation and wound pH Wound pH and Surface Temperature as a Predictive Biomarker of Healing in Diabetic Foot Ulcers - Bhavani Prasad Mahindrakar, Aakansha Giri Goswami, Farhanul Huda, Manisha Naithani, Somprakas Basu, 2023 This graphic from another manuscript (Roychoudhury and coworkers) DOI:10.1149/2.0231808jes Aim To monitor wound pH and surface temperature as... Continue Reading →

Simultaneous Segmentation and Classification of Pressure Injury Image Data Using Mask-R-CNN ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC @USC_vascular @ResearchatUSC @KeckSchool_USC #AI #DeepLearning @TheNPIAP

This just published from our SALSA team led by Mark Swerdlow. We're already getting data requests on this one. Building on these models is what it's all about! Mark Swerdlow,1Ozgur Guler,2Raphael Yaakov,2and David G. Armstrong1 Background. Pressure injuries (PIs) impose a substantial burden on patients, caregivers, and healthcare systems, affecting an estimated 3 million Americans and... Continue Reading →

Smart Wearable Systems for the Remote Monitoring of Selected Vascular Disorders of the Lower Extremity: A Systematic Review #C2SHiP #Wearable #Diagnostic #Theragnostic

A good contribution from Souza and coworkers This systematic review aims at providing an overview of the state of the art regarding smart wearable systems (SWS) applications to monitor the status of patients suffering from vascular disorders of the lower extremity. Peer-reviewed literature has been analyzed to identify employed data collection methods, system characteristics, and... Continue Reading →

Novel Biomarkers for Charcot Foot: A Review of the Literature

An excellent contribution to the literature from Bobirca and coworkers from Bucharest. Abstract Background: Although Charcot diabetic foot (CDF) is a frequent complication of diabetic neuropathy, less is known about the possibility of its early prevention. Methods: A review of the original articles published in English, using the “biomarkers AND Charcot’s foot” criterion, resulted in 33... Continue Reading →

Probiotics and the gut-wound axis

Here is more cogent information to support the contention that we might consider adding bacteria rather than just removing it. To (again) use a military analogy, what one might describe as "clear, hold, and build" rather than just "clear". A Review of Immunomodulatory Reprogramming by Probiotics in Combating Chronic and Acute Diabetic Foot Ulcers (DFUs)... Continue Reading →

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