Smart Wearable Systems for the Remote Monitoring of Selected Vascular Disorders of the Lower Extremity: A Systematic Review #C2SHiP #Wearable #Diagnostic #Theragnostic

A good contribution from Souza and coworkers This systematic review aims at providing an overview of the state of the art regarding smart wearable systems (SWS) applications to monitor the status of patients suffering from vascular disorders of the lower extremity. Peer-reviewed literature has been analyzed to identify employed data collection methods, system characteristics, and... Continue Reading →

Novel Biomarkers for Charcot Foot: A Review of the Literature

An excellent contribution to the literature from Bobirca and coworkers from Bucharest. Abstract Background: Although Charcot diabetic foot (CDF) is a frequent complication of diabetic neuropathy, less is known about the possibility of its early prevention. Methods: A review of the original articles published in English, using the “biomarkers AND Charcot’s foot” criterion, resulted in 33... Continue Reading →

Probiotics and the gut-wound axis

Here is more cogent information to support the contention that we might consider adding bacteria rather than just removing it. To (again) use a military analogy, what one might describe as "clear, hold, and build" rather than just "clear". A Review of Immunomodulatory Reprogramming by Probiotics in Combating Chronic and Acute Diabetic Foot Ulcers (DFUs)... Continue Reading →

A wound alkalinity measurement to predict non-healing wound outcomes: A literal litmus test #Diagnostics #Theragnostics #WoundHealiing #Diabetic Foot

Again, a literal litmus test to help guide therapy. From Senkowsky and coworkers in JWC More work can be found here and here and here and here (etc). Abstract Objective: As wound pH could influence wound healing rates, this study examined the alkalinity of the entire wound during patients' follow-up visits to predict the final non-healing... Continue Reading →

Can Wound Surface pH and Temperature Predict Wound Healing in Diabetic Foot Ulcer? #Theragnostics #Diagnostics #DiabeticFootUlcer

More data supporting diagnostics and theragnostics like wound pH and thermometry. Introduction: Diabetic foot ulcer (DFU) is dreaded and one of the most intricate medical conditions in diabetes. Improving the healing of DFU is imperative for improved patient outcomes. To consider a biomarker of comprehensive value to patients and health care professionals, it should be cost... Continue Reading →

The effect of inflammation management on pH, temperature, and bacterial burden #ActAgainstAmputation #WoundHealing

Important work from Derwin and coworkers in Zena Moore's group. The aim of this feasibility study was to investigate the impact of inflammation management on wound pH, temperature, and bacterial burden, using the principles of TIME and Wound Bed Preparation. A quantitative non-comparative, prospective, descriptive observational design. Following ethical approval, 26 participants with 27 wounds... Continue Reading →

Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions #Theragnostics #Diagnostics @CSHL @UnivMiami

A great perspective from Pastar and coworkers from our long-time friend Marjana Tomic-Canic's lab at University of Miami published in Cold Spring Harbor Perspectives in Biology. Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds with multifactorial etiologies that are associated... Continue Reading →

Bacterial Protease Activity (BPA) may reduce Hospitalization, Improve Quality of LIfe: RCT #Theragnostics #Diagnostics #ActAgainstAmputation

This published in the Journal of Wound Care Effectiveness of testing hard-to-heal wounds for bacterial protease activity: a randomised clinical trial The rapid lateral flow test for BPA is easy to perform, provides actionable results at the point-of-care, and is a useful diagnostic tool to assist wound care clinicians in evidence-based treatment decisions

Factors Influencing the Risk of Major Amputation inPatients with Diabetic Foot Ulcers Treated by Autologous Cell Therapy @ALPSLimb #ActAgainstAmputation

Great work from our colleagues at IKEM and Manchester. Bottom line: Pay attention to CRP, polymorphisms to methylenetetrahydrofolate reductase (MTHFR) as well as low TCPO2 Key points: The aim of our study was to assess the risk factors for major amputation in patients with CLTI and DFU during a 2-year follow-up after ACT.One hundred and... Continue Reading →

Bioinformatic Analysis Reveals Hub Immune-Related Genes of Diabetic Foot Ulcers #ActAgainstAmputation

This from Rong and coworkers Summary Points: Diabetic foot ulcer (DFU) is a complex and devastating complication of diabetes mellitus that are usually stagnant in the inflammatory phase.However, oral wound healing, which is characterized by a rapid and scarless healing process, is regarded an ideal model of wound healing.Thus, we performed a comprehensive bioinformatics analysis... Continue Reading →

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