Continued data / guidance to better define dosing activity as we might dose a drug. From our colleagues Jaap Van Netten, Vera Fijen and and Sicco Bus. Introduction: Weight-bearing physical activity is important for people with diabetes-related foot disease, but may also contribute to ulceration or delayed ulcer healing. No overview of weight-bearing activity of people... Continue Reading →
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing #smallmolecule @naturecomms
There are precious few small molecule (aka drug) solutions for wound healing. Perhaps this is one of an emerging trend. Impaired wound healing and ulcer complications are a leading cause of death in diabeticpatients. In this study, we report the design and synthesis of a cyclometalated iridium(III)metal complex 1a as a stabilizer of hypoxia-inducible factor-1α... Continue Reading →