Congratulations to the UCSF toe and flow team on this important work Article Highlights: Type of Research: Multi-center retrospective cohort study Key Findings: Patients with chronic limb-threatening ischemia requiring transmetatarsal amputation had a higher rate of healing with open revascularization procedures as compared to endovascular. Additionally, post-operative community-level ambulation was more frequently achieved following open... Continue Reading →
The influence of debridement on diabetic foot ulcers: nationwide utilization and outcomes
Tettelbach and coworkers have more compelling data supporting debridement. Objective: To determine the role of debridement when patients are using placental-derived allografts (PDAs), data from two prospective, multicentre, randomised controlled trials (RCTs) were evaluated for the quality or adequacy of debridement on diabetic foot ulcers (DFUs) treated with PDAs. Results were compared with real-world findings via... Continue Reading →
AlphaFold Protein Structure Database
AlphaFold has now all 200+ million proteins in the known protein universe. What this has in store for us in medicine, science, environmental intervention is extraordinary and almost inconceivable. AlphaFold Protein Structure Database — Read on alphafold.ebi.ac.uk/
Skin autofluorescence for non-enzymatic glycation end products in Diabetic Foot Ulcers (DFUs)- A meta analysis
Continued efforts to create companion diagnostics and theragnostics to help us measure what we manage and predict DFU risk. Imagine diagnosing "friable" tissue and then doing something about it?! Objective: Skin autofluorescence (SAF) has been suggested as a novel and noninvasive technique for assessing tissue accumulation of advanced glycation end products in diabetes and related complications.... Continue Reading →
Factors Associated With Healing of Diabetes-Related Foot Ulcers: Data From a Large Prospective Real-World Cohort
These important data from our Australian SALSAmigos, Zhang and coworkers was published in Diabetes Care.
Cutaneous Innervation in Impaired Diabetic Wound Healing
From Nowak and coworkers at Northwestern. Type 2 diabetes (T2D) is associated with several potential comorbidities, among them impaired wound healing, chronic ulcerations, and the requirement for lower extremity amputation. Disease-associated abnormal cellular responses, infection, immunological and microvascular dysfunction, and peripheral neuropathy are implicated in the pathogenesis of the wound healing impairment and the diabetic... Continue Reading →
20 years of Control Groups in Diabetic Foot Ulcer Studies: Improved healing (12 weeks- 24% to 33% / 20 weeks- 31% to 43%), but room for improvement.
Important work from our SALSAmigos from UT Southwestern and University of Cincinnati. Progress in Diabetic Foot Ulcer Healing with Standard of Care Therapy Alone: A Meta-analysisVIRGINIA E. PARKS, PETER CRISOLOGO, LAWRENCE A. LAVERY, JAMINELLI BANKS, MICHAEL D. LIETTE and LANCE JOHNSON Background: The purpose of this study was to evaluate whether or not standard of... Continue Reading →