On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
Margin-directed antibiotic therapy after surgery for diabetic foot osteomyelitis is appealing, but surgical assessment, histopathology, and microbiology often provide different answers. A new Clinical Infectious Diseases Viewpoint explains why multidisciplinary interpretation and prospective standardization are essential.
Senneville and Lipsky return with a measured rejoinder in Clinical Infectious Diseases (April 2026), arguing that the Lagrand trial shows the absence of evidence of superiority — not definitive equivalence — between ulcer-bed and bone biopsy for guiding antibiotic therapy in diabetic foot osteomyelitis.
A new study from our USC group shows Medicaid patients with diabetic foot ulcers face 18% higher odds of infection hospitalization and 72% higher odds of major amputation — despite being younger and having comparable comorbidity burden after matching. The data point to structural vulnerability, not biology.
A new nationwide study out of Taiwan adds fresh weight to the growing list of potential benefits offered by GLP-1 receptor agonists (GLP-1RAs)—a class of medications already known for their glycemic control, cardiovascular protection, and weight loss benefits. This time, the focus is on something more insidious: infections that land people in the hospital. In... Continue Reading →
In the complex world of wound care, innovation often finds inspiration in nature. Nitric oxide (NO), a simple yet potent molecule, is gaining recognition for its remarkable antimicrobial and antibiofilm properties. A recent review by Roberts et al., Harnessing the Power of Our Immune System: The Antimicrobial and Antibiofilm Properties of Nitric Oxide, highlights the growing... Continue Reading →
In a comprehensive study published in Diabetes Care, Lipska et al. examined the relationship between glycemic control and infection-related hospitalization risk in older adults with type 2 diabetes. The findings provide nuanced insights into the balance between intensive and relaxed glycemic targets, particularly as clinical guidelines evolve to prioritize individualized care. Study Objectives and Design The... Continue Reading →
Diabetic foot infections are a significant concern, often leading to severe complications, including amputation. Recent advancements in molecular microbiology have shown promise in improving our understanding and management of these infections. A recent review by Sande et al. (2023) critically evaluates the use of next-generation molecular assays, such as metagenomics and metatranscriptomics, in diagnosing and... Continue Reading →
Great work from our colleagues Schmidt and Pop-Busui and colleagues from University of Michigan in Diabetes Care.
Nutritional Interventions May Improve Outcomes of Patients Operated on for Diabetic Foot Infections: A Single-Center Case-Control Study Nutritional Interventions May Improve Outcomes of Patients Operated on for Diabetic Foot Infections: A Single-Center Case-Control Study Great work from our long-time friend and colleague Prof. Ilker Uckay of Zurich's Balgrist hospital. JDR_9546144 1..6 Nutritional Interventions May Improve... Continue Reading →
Excellent work in diagnostics and theragnostics from Brunauer and coworkers in the journal Biosensors. Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay Abstract: The rapid detection of pathogens in infected wounds can significantly improve the clinical outcome. Wound exudate, which can be collected in a non-invasive way, offers an attractive... Continue Reading →
