On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
Senneville and Lipsky return with a measured rejoinder in Clinical Infectious Diseases (April 2026), arguing that the Lagrand trial shows the absence of evidence of superiority — not definitive equivalence — between ulcer-bed and bone biopsy for guiding antibiotic therapy in diabetic foot osteomyelitis.
A new study from our USC group shows Medicaid patients with diabetic foot ulcers face 18% higher odds of infection hospitalization and 72% higher odds of major amputation — despite being younger and having comparable comorbidity burden after matching. The data point to structural vulnerability, not biology.
A new nationwide study out of Taiwan adds fresh weight to the growing list of potential benefits offered by GLP-1 receptor agonists (GLP-1RAs)—a class of medications already known for their glycemic control, cardiovascular protection, and weight loss benefits. This time, the focus is on something more insidious: infections that land people in the hospital. In... Continue Reading →
In the complex world of wound care, innovation often finds inspiration in nature. Nitric oxide (NO), a simple yet potent molecule, is gaining recognition for its remarkable antimicrobial and antibiofilm properties. A recent review by Roberts et al., Harnessing the Power of Our Immune System: The Antimicrobial and Antibiofilm Properties of Nitric Oxide, highlights the growing... Continue Reading →
In a comprehensive study published in Diabetes Care, Lipska et al. examined the relationship between glycemic control and infection-related hospitalization risk in older adults with type 2 diabetes. The findings provide nuanced insights into the balance between intensive and relaxed glycemic targets, particularly as clinical guidelines evolve to prioritize individualized care. Study Objectives and Design The... Continue Reading →
Diabetic foot infections are a significant concern, often leading to severe complications, including amputation. Recent advancements in molecular microbiology have shown promise in improving our understanding and management of these infections. A recent review by Sande et al. (2023) critically evaluates the use of next-generation molecular assays, such as metagenomics and metatranscriptomics, in diagnosing and... Continue Reading →
Great work from our colleagues Schmidt and Pop-Busui and colleagues from University of Michigan in Diabetes Care.
Nutritional Interventions May Improve Outcomes of Patients Operated on for Diabetic Foot Infections: A Single-Center Case-Control Study Nutritional Interventions May Improve Outcomes of Patients Operated on for Diabetic Foot Infections: A Single-Center Case-Control Study Great work from our long-time friend and colleague Prof. Ilker Uckay of Zurich's Balgrist hospital. JDR_9546144 1..6 Nutritional Interventions May Improve... Continue Reading →
Excellent work in diagnostics and theragnostics from Brunauer and coworkers in the journal Biosensors. Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay Abstract: The rapid detection of pathogens in infected wounds can significantly improve the clinical outcome. Wound exudate, which can be collected in a non-invasive way, offers an attractive... Continue Reading →
Timely work from our SALSAmigos at King's. Aim The diabetic foot attack (DFA) is perhaps the most devastating form of diabetic foot infection, presenting with rapidly progressive skin and tissue necrosis, threatening both limb and life. However, clinical outcome data in this specific group of patients are not available. Methods Analysis of 106 consecutive patients who underwent emergency hospitalisation... Continue Reading →
