On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
Does the skin heat up before it breaks down in diabetic foot ulceration? Compelling and provocative work from our Dutch colleagues. They've published more on this important subject in the past few years than anyone and what we may be seeing is that, for some patients, thermometry may not be as accurate. While this idea... Continue Reading →
This from our colleagues in Carlisle, UK. We see more chairside/bedside diagnostics and theragnostics to help measure what we manage. Background: Point-of-care testing for infection might help podiatric physicians optimize management of diabetic foot ulcers (DFUs). Glycologic's proprietary GLYWD product has been developed to detect changes in a patient's immunologic/inflammatory response related to wound infection. We... Continue Reading →
Calluses are defined as “hyperkeratosis caused by excessive mechanical loading in particular areas” and can contribute to the development of diabetic foot ulcers（DFUs）. Callus inflammation is a premonitory symptom of DFUs. To prevent DFUs, recent studies have recommended thermographic monitoring of foot skin temperature, which is recognized as a sign of skin inflammation. However, no... Continue Reading →
More data supporting diagnostics and theragnostics like wound pH and thermometry. Introduction: Diabetic foot ulcer (DFU) is dreaded and one of the most intricate medical conditions in diabetes. Improving the healing of DFU is imperative for improved patient outcomes. To consider a biomarker of comprehensive value to patients and health care professionals, it should be cost... Continue Reading →
Yet more insight into the mechanism of action of NPWT. From Wang and coworkers in the International Journal of Lower Extremity Wounds (IJLEW). Aims: Diabetic foot results in frequent amputation and quality-of-life reduction in diabetes population. These lesions are featured by a prolonged and exaggerated inflammation with a significant impairment in local bacterial invasion. Negative pressure... Continue Reading →
Great work from Wendland and Doolittle.
A terrific review by Rome's Serini and Calviello Long-chain Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) are widely recognized as powerful negative regulators of acute inflammation. However, the precise role exerted by these dietary compounds during the healing process is still largely unknown, and there is increasing interest in understanding their specific effects on the implicated... Continue Reading →
A great review from Queensland that should help put some of the confusing M1-M2 phenotype story into sharper relief. Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds Abstract: Macrophages play a prominent role in wound healing. In the early stages, they promote inflammation and remove pathogens, wound debris, and cells that... Continue Reading →
The Thermo-Pressure Concept: A New Model in Diabetic Foot Risk Stratification This from our Maltese SALSAmigos, Perren and coworkers Abstract: Elevated foot pressure and high temperatures have been proposed as predictive factors for diabetic foot ulceration; however, on their own, their predictive value is still questionable. This pilot study hypothesized that combining these two measurements... Continue Reading →
Compelling work from Fields at Scripps, Florida suggest that we may be entering a new era of selective MMP inhibitors that may have profound implications from wound healing to cancer therapy. Buckle up!
