Does the skin heat up before it breaks down in diabetic foot ulceration? Compelling and provocative work from our Dutch colleagues. They've published more on this important subject in the past few years than anyone and what we may be seeing is that, for some patients, thermometry may not be as accurate. While this idea... Continue Reading →
Evaluation of Glycologic Point-of-Care Infection Test Kit for Diabetic Foot Ulcers in Relation to Bacterial Presence: A Prospective Cohort Study #ActAgainstAmputation @JAPMAfeettweets
This from our colleagues in Carlisle, UK. We see more chairside/bedside diagnostics and theragnostics to help measure what we manage. Background: Point-of-care testing for infection might help podiatric physicians optimize management of diabetic foot ulcers (DFUs). Glycologic's proprietary GLYWD product has been developed to detect changes in a patient's immunologic/inflammatory response related to wound infection. We... Continue Reading →
Association between elevated skin temperature of the foot callus and inflammatory marker in people with diabetes #ActAgainstAmputation #Diagnostic #Theragnostic #DiabeticFoot
Calluses are defined as “hyperkeratosis caused by excessive mechanical loading in particular areas” and can contribute to the development of diabetic foot ulcers（DFUs）. Callus inflammation is a premonitory symptom of DFUs. To prevent DFUs, recent studies have recommended thermographic monitoring of foot skin temperature, which is recognized as a sign of skin inflammation. However, no... Continue Reading →
Can Wound Surface pH and Temperature Predict Wound Healing in Diabetic Foot Ulcer? #Theragnostics #Diagnostics #DiabeticFootUlcer
More data supporting diagnostics and theragnostics like wound pH and thermometry. Introduction: Diabetic foot ulcer (DFU) is dreaded and one of the most intricate medical conditions in diabetes. Improving the healing of DFU is imperative for improved patient outcomes. To consider a biomarker of comprehensive value to patients and health care professionals, it should be cost... Continue Reading →
Negative Pressure Wound Therapy Promotes Wound Healing by Inhibiting Inflammation in Diabetic Foot Wounds: A Role for NOD1 Receptor
Yet more insight into the mechanism of action of NPWT. From Wang and coworkers in the International Journal of Lower Extremity Wounds (IJLEW). Aims: Diabetic foot results in frequent amputation and quality-of-life reduction in diabetes population. These lesions are featured by a prolonged and exaggerated inflammation with a significant impairment in local bacterial invasion. Negative pressure... Continue Reading →
Reliability of Low-Cost Thermometers for Monitoring Foot Temperature #DiabeticFoot #C2SHiP
Great work from Wendland and Doolittle.
New Insights on the Effects of Dietary Omega‐3 Fatty Acids on Impaired Skin Healing in DFU and VLU #DiabeticFoot #Wound Healing
A terrific review by Rome's Serini and Calviello Long-chain Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) are widely recognized as powerful negative regulators of acute inflammation. However, the precise role exerted by these dietary compounds during the healing process is still largely unknown, and there is increasing interest in understanding their specific effects on the implicated... Continue Reading →
Mixed up Macrophages: M1/M2 Dysregulation in Diabetic Foot Ulcers
A great review from Queensland that should help put some of the confusing M1-M2 phenotype story into sharper relief. Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds Abstract: Macrophages play a prominent role in wound healing. In the early stages, they promote inflammation and remove pathogens, wound debris, and cells that... Continue Reading →
The Thermo-Pressure Concept: A New Model in Diabetic Foot Risk Stratification
The Thermo-Pressure Concept: A New Model in Diabetic Foot Risk Stratification This from our Maltese SALSAmigos, Perren and coworkers Abstract: Elevated foot pressure and high temperatures have been proposed as predictive factors for diabetic foot ulceration; however, on their own, their predictive value is still questionable. This pilot study hypothesized that combining these two measurements... Continue Reading →
The Rebirth of Matrix Metalloproteinase (MMP) Inhibitors?
Compelling work from Fields at Scripps, Florida suggest that we may be entering a new era of selective MMP inhibitors that may have profound implications from wound healing to cancer therapy. Buckle up!