Oral Is the New IV. Challenging Decades of Blood and Bone Infection Dogma: A Systematic Review @bradspellberg @lacuscmedcenter @usc

Superb work from Wald–Dickler and coworkers adding to the growing body of evidence that (to coin a phrase from senior author Brad Spellberg), shorter may be better and oral > IV. Background We sought to determine if controlled, prospective clinical data validate the long-standing belief that intravenous (IV) antibiotic therapy is required for the full […]

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The microbiology of diabetic foot infections: a meta-analysis

The microbiology of diabetic foot infections: a meta-analysisExcellent work from MacDonald and coworkers from Edinburgh. The microbiology of diabetic foot infections: a meta-analysis Background: Diabetic foot ulcers are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. There have been numerous studies of the microbiology of diabetic foot infec- […]

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Lower extremity reamputation in people with diabetes: a systematic review and meta-analysis @ALPSlimb #ActAgainstAmputation @USC_vascular @apma @keckmedusc @DiabetesRC

Lower extremity reamputation in people with diabetes: a systematic reviewand meta-analysis This from Liu and our group evaluating the best available evidence on reamputation. The bottom line: 1 year reamputation: 19%, 5 year reamputation 37.1%, 5 year contralateral reamputation: 20.5%. No trend for improvement or worsening over the past 2 decades. Lower extremity reamputation in […]

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Genetic Polymorphisms and the Risk of Diabetic Foot: A Systematic Review and Meta-Analyses

Up-to-date data on polymorphisms in the diabetic foot in this meta-analysis from Zhao and coworkers. Background Diabetic foot (DF) is a dangerous complication of diabetes. The aim of the study was to synthesize all the published single nucleotide polymorphisms (SNPs) of DF to objectively evaluate the relationship of SNPs and DF risks. Methods The HuGE […]

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Preventing foot ulceration in diabetes: systematic review and meta-analyses of RCT data #DiabeticFoot #Remission #ActAgainstAmputation @Diabetologia

Strong work from Fay Crawford and team! Aims/hypothesis Foot ulceration is a serious complication for people with diabetes that results in high levels of morbidity for individuals and significant costs for health and social care systems. Nineteen systematic reviews of preventative interventions have been published, but none provides a reliable numerical summary of treatment effects. […]

Read More Preventing foot ulceration in diabetes: systematic review and meta-analyses of RCT data #DiabeticFoot #Remission #ActAgainstAmputation @Diabetologia