On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
A new multi-omics preprint uses Mendelian randomization to argue that six circulating miRNAs causally regulate peripheral artery disease in the diabetic foot—and flags metformin as the most translationally tractable repurposing candidate. A nice piece of computational scaffolding, with the usual in-silico caveats.
Imagine an exosome cargo delivery system for mRNAs... Diabetic foot ulcers are one of the most common complications of diabetes, requiring repeated surgical intervention and leading to amputation. Owing to the lack of effective drugs, novel therapeutics need to be explored. Decreased angiogenic factors, endothelial cell dysfunction and vascular lumen stenosis impair angiogenesis in diabetic... Continue Reading →
Generalized description of MicroRNAs Zhao and coworkers continue strengthening the research toward companion diagnostics with these strong data supporting assessing micro-RNA 103 (miRNA 103) levels in tissue margins. Changes in miroRNA103 expression in wound margin tissue are related to wound healing of diabetes foot ulcers Key Messages microRNAs (miRNAs) are involved in the regulation of... Continue Reading →
