An email from Ben Lipsky brings new biomarker data — IL-17, IL-12p70, HMGB1, IL-8, CRP — that may be the strongest case yet for splitting "moderate" and "severe" diabetic foot infections in the IDSA and WIfI classification.
Rethinking mildly infected diabetic foot ulcers: lessons from Gleason and cancer taxonomy #ActAgainstAmputation
Inspired by much recent discussion as well as a blog post from 13 years ago, here is a manuscript just published. After further discussion with Prof. Ben Lipsky, he raises the interesting idea of calling some of these "infection in situ" just like cancer in situ.