Tag: nature

Galectin-3 and Diabetic Wound Healing: Turning On the Growth Switch While Releasing the Brakes #ActAgainstAmputation #DiabeticFoot

A new study in Nature Communications uncovers how a sugar-binding protein, Galectin-3, can be harnessed to speed healing in diabetic foot ulcers โ€” and how to bypass a major biochemical roadblock.** Diabetic foot ulcers (DFUs) remain one of the most stubborn complications of diabetes โ€” affecting up toย 30%ย of patients, with recurrence rates approachingย 65%ย within 3โ€“5 years and... Continue Reading →

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Chronic Wounds @DiseasePrimers @Nature

A magnum opus from Vince Falanga, Rosyln Isseroff, Athena Soulika, Marco Romanelli, Dave Margolis, Suzanne Kapp, Mark Granick, and Keith Harding. Chronic wounds Abstract | Chronic wounds are characterized by their inability to heal within an expected time frame and have emerged as an increasingly important clinical problem over the past several decades, owing to... Continue Reading →

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A small molecule HIF-1ฮฑ stabilizer that accelerates diabetic wound healing #smallmolecule @naturecomms

There are precious few small molecule (aka drug) solutions for wound healing. Perhaps this is one of an emerging trend. Impaired wound healing and ulcer complications are a leading cause of death in diabeticpatients. In this study, we report the design and synthesis of a cyclometalated iridium(III)metal complex 1a as a stabilizer of hypoxia-inducible factor-1ฮฑ... Continue Reading →

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