From Nowak and coworkers at Northwestern. Type 2 diabetes (T2D) is associated with several potential comorbidities, among them impaired wound healing, chronic ulcerations, and the requirement for lower extremity amputation. Disease-associated abnormal cellular responses, infection, immunological and microvascular dysfunction, and peripheral neuropathy are implicated in the pathogenesis of the wound healing impairment and the diabetic […]Read More Cutaneous Innervation in Impaired Diabetic Wound Healing
Excellent work from Solomon Tesfaye and team at the Royal Hallamshire in Sheffield in Nature Reviews Endocrinology on the pathogenesis and management of diabetic peripheral neuropathy.Read More Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy @naturerevendo
Intriguing report from Petersen and coworkers for a common, complex and costly condition. Importance Many patients with diabetic peripheral neuropathy experience chronic pain and inadequate relief despite best available medical treatments. Objective To determine whether 10-kHz spinal cord stimulation (SCS) improves outcomes for patients with refractory painful diabetic neuropathy (PDN). Design, Setting, and Participants The prospective, multicenter, open-label […]Read More Effect of High-frequency Spinal Cord Stimulation in Patients With Painful Diabetic #Neuropathy: A Randomized Clinical Trial @JAMANeuro
Important work from Hicks and coworkers from Hopkins. Peripheral Neuropathy and All-Cause and Cardiovascular Mortality in U.S. Adults Background: Growing evidence indicates that peripheral neuropathy (PN) is common even in the absence of diabetes. How- ever, the clinical sequelae of PN have not been quantified in the general population. Objective: To assess the associations of […]Read More Peripheral Neuropathy and All-Cause and Cardiovascular Mortality in U.S. Adults @annalsofIM @CaitlinWHicks #PeripheralNeuropathy
Intriguing data from Thessaloniki, Tubingen and Sheffield seem to lend more credence to normalizing methylcobalamin (Vitamin B12) in people with diabetic neuropathy. Aim: To investigate the effect of normalizing vitamin B12 (B12) levels with oral B12 (methylcobalamin) 1000 μg/day for one year in patients with diabetic neuropathy (DN). Patients and methods: In this prospective, double-blind, placebo-controlled trial, […]Read More Does Normalizing Vitamin B12 Improve Signs and Symptoms of Neuropathy? Results of a One-Year Randomized Controlled Trial
Important work from our long-time SALSAmigo, Rayaz Malik and team. Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy published in Nature Scientific Reports. Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy Accurately quantifying the progression of diabetic peripheral neuropathy is key to identify individuals who will progress […]Read More Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy @SciReports @WCMQatar
Important new work from our Lyonnaise and German colleagues published in the journal Diabetes. Neurovascular response to pressure in patients with diabetic foot ulcer Julien Vouillarmet MD1, Audrey Josset-Lamaugarny2,3, Paul Michon MD1, Jean Louis Saumet MD, PhD2,3, Audrey Koitka-Weber PhD4,5, Samir Henni MD4, Berengere Fromy PhD2,3, Dominique Sigaudo-Roussel PhD2,3 Diabetic foot ulcer (DFU) is a […]Read More Study: People with Diabetic Foot Ulcers Don’t Vasodilate after Pressure Challenge. A New Marker for Risk (and Treatment Target)?