Cutaneous Innervation in Impaired Diabetic Wound Healing

From Nowak and coworkers at Northwestern. Type 2 diabetes (T2D) is associated with several potential comorbidities, among them impaired wound healing, chronic ulcerations, and the requirement for lower extremity amputation. Disease-associated abnormal cellular responses, infection, immunological and microvascular dysfunction, and peripheral neuropathy are implicated in the pathogenesis of the wound healing impairment and the diabetic […]

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Effect of High-frequency Spinal Cord Stimulation in Patients With Painful Diabetic #Neuropathy: A Randomized Clinical Trial @JAMANeuro

Intriguing report from Petersen and coworkers for a common, complex and costly condition. Importance  Many patients with diabetic peripheral neuropathy experience chronic pain and inadequate relief despite best available medical treatments. Objective  To determine whether 10-kHz spinal cord stimulation (SCS) improves outcomes for patients with refractory painful diabetic neuropathy (PDN). Design, Setting, and Participants  The prospective, multicenter, open-label […]

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Peripheral Neuropathy and All-Cause and Cardiovascular Mortality in U.S. Adults @annalsofIM @CaitlinWHicks #PeripheralNeuropathy

Important work from Hicks and coworkers from Hopkins. Peripheral Neuropathy and All-Cause and Cardiovascular Mortality in U.S. Adults Background: Growing evidence indicates that peripheral neuropathy (PN) is common even in the absence of diabetes. How- ever, the clinical sequelae of PN have not been quantified in the general population. Objective: To assess the associations of […]

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Does Normalizing Vitamin B12 Improve Signs and Symptoms of Neuropathy? Results of a One-Year Randomized Controlled Trial

Intriguing data from Thessaloniki, Tubingen and Sheffield seem to lend more credence to normalizing methylcobalamin (Vitamin B12) in people with diabetic neuropathy. Aim: To investigate the effect of normalizing vitamin B12 (B12) levels with oral B12 (methylcobalamin) 1000 μg/day for one year in patients with diabetic neuropathy (DN). Patients and methods: In this prospective, double-blind, placebo-controlled trial, […]

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Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy @SciReports @WCMQatar

Important work from our long-time SALSAmigo, Rayaz Malik and team. Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy published in Nature Scientific Reports. Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy Accurately quantifying the progression of diabetic peripheral neuropathy is key to identify individuals who will progress […]

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Study: People with Diabetic Foot Ulcers Don’t Vasodilate after Pressure Challenge. A New Marker for Risk (and Treatment Target)?

Important new work from our Lyonnaise and German colleagues published in the journal Diabetes. Neurovascular response to pressure in patients with diabetic foot ulcer Julien Vouillarmet MD1, Audrey Josset-Lamaugarny2,3, Paul Michon MD1, Jean Louis Saumet MD, PhD2,3, Audrey Koitka-Weber PhD4,5, Samir Henni MD4, Berengere Fromy PhD2,3, Dominique Sigaudo-Roussel PhD2,3 Diabetic foot ulcer (DFU) is a […]

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