On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
Subtle and compelling work from our toemigos Larry Lavery and Dane Wukich's team led by David Truong. Background. The aim of this study was to evaluate clinical outcomes in the published literature on medical and surgical management of diabetic foot osteomyelitis (DFO). Methods. A PubMed and Google Scholar search of articles relating to DFO was... Continue Reading →
Bone cultures? Clean margins for pathology? Both? These data from Voon and colleagues add more fuel to the discussionBackground: Trans-phalangeal and trans-metatarsal amputation, collectively termed 'minor amputations' are important procedures for managing infections of diabetes-related foot ulcers (DFU). Following minor amputation, international guidelines recommend a prolonged course of antibiotics if residual infected bone on intra-operative... Continue Reading →
Superb work from Wald-Dickler and coworkers adding to the growing body of evidence that (to coin a phrase from senior author Brad Spellberg), shorter may be better and oral > IV. Background We sought to determine if controlled, prospective clinical data validate the long-standing belief that intravenous (IV) antibiotic therapy is required for the full... Continue Reading →
Intriguing work by Ehya and coworkers. Abstract This study explored the clinical effectiveness of antibiotic-loaded bone cement on primary treatment of diabetic foot infection. This is a randomized controlled study, including thirty-six patients with diabetic foot ulcer complicated by osteomyelitis who had undergone treatment between May 2018 and December 2019. Patients were randomly divided into... Continue Reading →
We look forward to this study and it's resultant findings from our good friend and colleague Edgar Peters and coworkers Diabetic foot osteomyelitis (DFO) poses a major disease burden. It can generally be treated with long-term antibacterial therapy. International guidelines recommend to base antibacterial therapy choices on percutaneous bone biopsy culture, while in practice, therapy... Continue Reading →
untitled Miki Fujii, MD, PhD* Hiroto Terashi, MD, PhD†Koichi Yokono, MD, PhD‡ David G. Armstrong, DPM, MD, PhD§ Background: Diabetic foot ulcers combined with ischemia and infection can be difficult to treat. Few studies have quantified the level of blood supply and infection control required to treat such complex diabetic foot ulcers. We aimed... Continue Reading →
Strong work from the superb team at the Beth Israel Deaconess in Boston. Look at the pre and post data on care of osteomyelitis! Bottom line: teamwork works, worldwide. Background: Diabetic Foot Osteomyelitis (DFO) is a common infection where treatment involves multiple services including Infectious Disease (ID), Podiatry, and Pathology. Despite its ubiquity in the hospital,... Continue Reading →
Here is a popular table from our recent Infectious Diseases Society of America Diabetic Foot Infection Guidelines discussing suggested durations of therapy for soft tissue and bone infections.
