A First RCT for Calcium Sulfate Pellets in Diabetic Foot Osteomyelitis Treatment: The BIG D-FOOT Study #ActAgainstAmputation

Diabetic foot osteomyelitis (DFO) is a formidable challenge in limb preservation, often leading to major amputations and significant morbidity. Systemic antibiotic treatments are fraught with limitationsโ€”poor tissue penetration due to peripheral arterial disease, risks of systemic toxicity, and antibiotic resistance. But what if we could deliver antibiotics exactly where they are needed most? A groundbreaking randomized controlled... Continue Reading →

Antibacterial Bone Cement – More Support for Use?

The logic behind antibiotic-loaded bone cement (ALBC) in the infected diabetic foot gets more attractive the longer you stare at it. Pack a debrided, infected wound with PMMA carrying vancomycin or gentamicin and you buy three things at once: a local antibiotic depot eluting at concentrations no IV line could safely deliver, obliteration of dead... Continue Reading →

Application and Clinical Effectiveness of Antibiotic-Loaded Bone Cement in the Treatment of Neuropathic Diabetic Foot Ulcers Complicated by Osteomyelitis: A Randomized Controlled Trial

Intriguing work by Ehya and coworkers. Abstract This study explored the clinical effectiveness of antibiotic-loaded bone cement on primary treatment of diabetic foot infection. This is a randomized controlled study, including thirty-six patients with diabetic foot ulcer complicated by osteomyelitis who had undergone treatment between May 2018 and December 2019. Patients were randomly divided into... Continue Reading →

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