Diabetic foot osteomyelitis (DFO) is a formidable challenge in limb preservation, often leading to major amputations and significant morbidity. Systemic antibiotic treatments are fraught with limitationsโpoor tissue penetration due to peripheral arterial disease, risks of systemic toxicity, and antibiotic resistance. But what if we could deliver antibiotics exactly where they are needed most? A groundbreaking randomized controlled... Continue Reading →
Antibacterial Bone Cement – More Support for Use?
The logic behind antibiotic-loaded bone cement (ALBC) in the infected diabetic foot gets more attractive the longer you stare at it. Pack a debrided, infected wound with PMMA carrying vancomycin or gentamicin and you buy three things at once: a local antibiotic depot eluting at concentrations no IV line could safely deliver, obliteration of dead... Continue Reading →
Application and Clinical Effectiveness of Antibiotic-Loaded Bone Cement in the Treatment of Neuropathic Diabetic Foot Ulcers Complicated by Osteomyelitis: A Randomized Controlled Trial
Intriguing work by Ehya and coworkers. Abstract This study explored the clinical effectiveness of antibiotic-loaded bone cement on primary treatment of diabetic foot infection. This is a randomized controlled study, including thirty-six patients with diabetic foot ulcer complicated by osteomyelitis who had undergone treatment between May 2018 and December 2019. Patients were randomly divided into... Continue Reading →