On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
A Stanford team has taught an algorithm to translate Doppler sounds into clinically meaningful ankle-brachial index ranges—potentially bringing vascular assessment closer to the point of care.
A new multi-omics preprint uses Mendelian randomization to argue that six circulating miRNAs causally regulate peripheral artery disease in the diabetic foot—and flags metformin as the most translationally tractable repurposing candidate. A nice piece of computational scaffolding, with the usual in-silico caveats.
A new 5,698-patient real-world cohort from Valladolid (Del Río-Solá et al., Adv Wound Care 2026) reports 61.8% five-year survival overall, falling to 32.1% after major amputation — and concludes the diabetic foot ulcer should be treated as a marker of advanced systemic disease, not an isolated wound. The newest entry in a fifteen-year line of evidence putting DFU mortality squarely in the cancer conversation.
Johann Georg Mönckeberg was a Hamburg patrician, born in 1877. His father — same name — was a senator of the free city, with the Mönckebergstrasse running from the Rathaus to the Hauptbahnhof named after him. The son grew up in a household where the name was already on the streets. He studied medicine at... Continue Reading →
Peripheral artery disease (PAD) is one of the most devastating complications of diabetes—contributing to ischemic pain, functional decline, and, in severe cases, amputation. Despite its prevalence, early detection remains elusive, and clinicians continue to search for simple, reliable markers of risk. A new multicohort study led by Wang and colleagues now shines a spotlight on... Continue Reading →
FOR IMMEDIATE RELEASE July 8, 2025 New Study Projects 360 Million Cases of Peripheral Artery Disease by 2050, Driven by Metabolic Risk and Aging Proactive Prevention Could Avert One in Three Cases Chongqing, Los Angeles — A landmark global study published today in Research (DOI: 10.34133/research.0702) projects a 220% increase in peripheral artery disease (PAD) cases worldwide by 2050,... Continue Reading →
Screenshot The realm of vascular health is continuously evolving, seeking more precise and reliable methods to diagnose and manage peripheral artery disease (PAD). A recent study by Ciuti et al., published in Diabetes Research and Clinical Practice, delves into the use of the resistive index (RI) and pulsatility index (PI) of the dorsal metatarsal artery... Continue Reading →
Diabetic foot ulcers (DFUs) are a significant global health concern, affecting a substantial number of individuals with diabetes. These ulcers often present challenges in achieving healing, leading to prolonged non-healing and, in some cases, necessitating amputation. However, a recent study by Liu et al. (2024) offers a promising new approach to managing DFUs[1]. The Study... Continue Reading →
The study by Liao et al. (2023) suggests significant differences in early hemodynamics after tibial transverse transport in patients with diabetic foot, focusing on those with nonarterial stenosis versus arterial stenosis. High-frequency color Doppler ultrasonography and laser Doppler flowmetry were used to assess changes. The study contributes to our understanding of diabetic foot treatment by... Continue Reading →
Here is the link to the guidelines for peripheral artery disease in people with diabetes. Diabetes-related foot complications have become a major cause of morbidity and are implicated in most major and minor amputations globally. Approximately 50% of people with diabetes and a foot ulcer have peripheral artery disease (PAD) and the presence of PAD... Continue Reading →
