Tag: RCT

The Back Slab Steps Forward: When ‘Good Enough’ Beats the Gold Standard — Results of an RCT on TCC vs. Posterior Splint #ActAgainstAmputation #Offloading #DiabeticFoot

There's a moment in most engineering disciplines when you have to confront an uncomfortable truth: the "best" solution on paper isn't always the best solution in the field. NASA learned this with the Space Shuttle — a magnificent machine that required 25,000 people and six months to turn around between flights. The Saturn V, by... Continue Reading →

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Phage Therapy: A Precision Strike Against Diabetic Foot Osteomyelitis #ActAgainstAmputation

Exciting new data from our friend and colleague Ben Lipsky and his team highlights a potential shift in how we approach one of our most stubborn challenges: Staphylococcus aureus (StA) in diabetic foot osteomyelitis (DFO). Current standards of care for DFO are often unsatisfactory. This Phase 2, randomized, double-blind, placebo-controlled trial investigated BX211, a personalized... Continue Reading →

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The Effect of Early Postop Physical Therapy on Wound Recurrence in Diabetic Foot Ulcers: A Randomized Controlled Trial #ToeFlowandGO #ActAgainstAmputation

Limb preservation in patients with diabetic foot ulcers (DFUs) is a multifaceted challenge requiring an interdisciplinary approach often captured by the mantra “Toe, Flow, and Go.” This framework integrates the essential contributions of podiatry (toe), vascular surgery (flow), and physical therapy (go) to address the complex needs of high-risk patients. The Role of Each Discipline... Continue Reading →

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Standard Treatments for Diabetic Foot Ulcers: Limited Effectiveness Highlighted in New Meta-Analysis

A recent meta-analysis, published in Wound Repair and Regeneration, systematically examined healing rates for diabetic neuropathic foot ulcers (DFUs) in patients receiving standard-of-care treatments. The study, led by Tyler Coye and a distinguished group of co-authors, including long-time research partner Lawrence A. Lavery, underscores a critical need for improved strategies in DFU management. Key Findings The analysis... Continue Reading →

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Exploring the Cost-Effectiveness of At-Home Skin Temperature Monitoring for Diabetic Foot Ulcer Prevention

In the realm of diabetes management, preventing foot ulcers is a critical challenge that affects millions globally. A recent multicenter randomized controlled trial spearheaded by our friends Jaap J. Van Netten and colleagues sheds light on the cost-effectiveness of an innovative approach: at-home skin temperature monitoring. This study, published in 2024, provides valuable insights into... Continue Reading →

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Flexor Tendon Tenotomy Treatment of the Diabetic Foot: A Multicenter Randomized Controlled Trial #ActAgainstAmputation @ALPSlimb @DiabetesCareADA

Important work from Andersen and coworkers on a potentially reproducible, minimally invasive clinical procedure to reduce pressure on distal digits with flexible deformities. Objective: The aim of this study was to evaluate the effects of needle flexor tendon tenotomy treatment of the diabetic hammertoe deformity. Research design and methods: A multicenter randomized controlled trial of individuals with... Continue Reading →

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Wound healing with “spray-on” autologous skin grafting (ReCell) compared with standard care in patients with large diabetes-related foot wounds: an open-label randomised controlled trial – PubMed

There is an urgent need for interventions that improve healing time, prevent amputations and recurrent ulceration in patients with diabetes-related foot wounds. In this randomised, open-label trial, participants were randomised to receive an application of non-cultured autologous skin cells ("spray- … — Read on pubmed.ncbi.nlm.nih.gov/34156758/ There was no difference in healing between active and control... Continue Reading →

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