An in vivo model for overloading-induced soft tissue injury #ActAgainstAmputation #DiabeticFoot #Theragnostics #Diagnostics @ALPSlimb @Staffsbiomech

Strong work from our Staffordshire colleagues Chatzistergos and Chockalingam who continue to help push the envelope in helping us collectively measure what we manage. An in vivo model for overloading-induced soft tissue injury This proof of concept study demonstrates that repetitive loading to the pain threshold can safely recreate overloading induced soft tissue damage and... Continue Reading →

Is a Left-to-Right >2.2°C Difference a Valid Measurement to Predict Diabetic Foot Ulceration in People in Diabetic Foot Remision? #Thermometry

Terrific work from Featherson and coworkers lending further light on the role (and limitations) of thermometry/thermography in predicting reulceration in diabetic foot remission Monitoring foot skin temperatures at home have been shown to be effective at preventing the occurrence of diabetic foot ulcers. In this study, the construct validity of using >2.2°C difference between contralateral... Continue Reading →

Skin autofluorescence for non-enzymatic glycation end products in Diabetic Foot Ulcers (DFUs)- A meta analysis

Continued efforts to create companion diagnostics and theragnostics to help us measure what we manage and predict DFU risk. Imagine diagnosing "friable" tissue and then doing something about it?! Objective: Skin autofluorescence (SAF) has been suggested as a novel and noninvasive technique for assessing tissue accumulation of advanced glycation end products in diabetes and related complications.... Continue Reading →

Study: People with Diabetic Foot Ulcers Don’t Vasodilate after Pressure Challenge. A New Marker for Risk (and Treatment Target)?

Important new work from our Lyonnaise and German colleagues published in the journal Diabetes. Neurovascular response to pressure in patients with diabetic foot ulcer Julien Vouillarmet MD1, Audrey Josset-Lamaugarny2,3, Paul Michon MD1, Jean Louis Saumet MD, PhD2,3, Audrey Koitka-Weber PhD4,5, Samir Henni MD4, Berengere Fromy PhD2,3, Dominique Sigaudo-Roussel PhD2,3 Diabetic foot ulcer (DFU) is a... Continue Reading →

High-Resolution Spectral Analysis Accurately Identifies the Bacterial Signature in Infected Chronic Foot Ulcers in People With Diabetes

Will we soon see more visual diagnostics for wounds? Congratulations to our colleagues in Melbourne for these intriguing data. Diabetic foot infections are a major cause of hospitalization, and delayed treatment can lead to numerous complications. The aim of this research was to investigate high-resolution spectroscopy of the wound center and periwound area for real-time... Continue Reading →

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