Author: David G. Armstrong

Dedicated to amputation prevention, wound healing, diabetic foot, biotechnology and the intersection between medical devices and consumer electronics.

Global estimates of diabetes-related amputations incidence in 2010 to 2020: A systematic review and meta-analysis #ActAgainstAmputation @ALPSlimb #DiabeticFoot

Global estimates of diabetes-related amputations incidence in 2010–2020: A systematic review and meta-analysis Great work from our Valencia and Pamplona Global estimates of diabetes-related amputations incidence in 2010–2020: A systematic review and meta-analysis Global estimates of diabetes-related amputations incidence in 2010–2020: A systematic review and meta-analysis Yasmin Ezzatvara, Antonio García-Hermoso Aims/hypothesis: This study sought to... Continue Reading →

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Development of AI classification model for angiosome-wise interpretive substantiation of plantar feet thermal asymmetry in type 2 diabetic subjects using infrared thermograms #Thermography #ActAgainstAmputation #Diagnostic

From our colleagues in Chennai. Abstract Diabetic Foot Syndrome (DFS) is the prime impetus for most of the lower extremity complications among the diabetic subjects. DFS is characterized by aberrant variations in plantar foot temperature distribution while healthy subjects exhibit a symmetric thermal pattern between the contralateral and ipsilateral plantar feet. Thus, "asymmetry analysis" of... Continue Reading →

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Evaluation of Glycologic Point-of-Care Infection Test Kit for Diabetic Foot Ulcers in Relation to Bacterial Presence: A Prospective Cohort Study #ActAgainstAmputation @JAPMAfeettweets

This from our colleagues in Carlisle, UK. We see more chairside/bedside diagnostics and theragnostics to help measure what we manage. Background: Point-of-care testing for infection might help podiatric physicians optimize management of diabetic foot ulcers (DFUs). Glycologic's proprietary GLYWD product has been developed to detect changes in a patient's immunologic/inflammatory response related to wound infection. We... Continue Reading →

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Effects of vildagliptin on wound healing and markers of inflammation in patients with type 2 diabetic foot ulcer: a prospective, randomized, double-blind, placebo-controlled, single-center study #ActAgainstAmputation @ALPSlimb

From our colleagues at James Cook University in Queensland, Australia. Introduction: Diabetic foot ulcers (DFU) are one of the leading long-term complications experienced by patients with diabetes. Dipeptidyl Peptidase 4 inhibitors (DPP4is) are a class of antihyperglycemic medications prescribed to patients with diabetes to manage glycaemic control. DPP4is may also have a beneficial effect on DFU... Continue Reading →

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@USC Podiatric Surgeon Armstrong Named Inaugural @UTHealthSA Lawrence B. Harkless Leadership Awardee #ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC @USC_vascular @ResearchatUSC @KeckSchool_USC @APMA

David G. Armstrong, Professor of Surgery and Director of the Southwestern Academic Limb Salvage Alliance (SALSA) at Keck School of Medicine of University of Southern California (USC) became the inaugural recipient of the University of Texas Health Science Center of San Antonio's Lawrence B. Harkless Leadership Award.The award, created in honor of long-time podiatric surgeon... Continue Reading →

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Pedal arterial calcification score is associated with hemodynamic change and major amputation after infrainguinal revascularization for chronic limb-threatening ischemia #ActAgainstAmputation @ALPSlimb @UCSFVascular

pMAC / Pedal Medial Arterial Calcification Score Yet more important work from our Toe- and Flowmigos @ UCSF. Objective: Pedal medial arterial calcification (pMAC) is associated with major amputation in patients with chronic limb-threatening ischemia (CLTI). We hypothesize that this association would be related to unresolved distal ischemia. We investigated relationships across pMAC score, hemodynamic change,... Continue Reading →

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Biomarkers of Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) in the Diabetic Foot: A Medical Record Review

Make the link between chronic kidney disease, pedal calcification...and even Charcot? This from our SALSAmigos at Washington University, St. Louis. Aims: Determine the prevalence and relative risk of having single and combinations of biomarkers of chronic kidney disease-mineral bone disorder (CKD-MBD) syndrome in the diabetic foot from an electronic medical record (EMR) review. Methods: Review of 152... Continue Reading →

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Microenvironment-Based Diabetic Foot Ulcer Nanomedicine #ActAgainstAmputation @ALPSlimb

An ambitious review from Huang and coworkers Diabetic foot ulcers (DFU), one of the most serious complications of diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, the DFU microenvironment is rather complicated and characterized by hyperglycemia, ischemia, hypoxia, hyperinflammation, and persistent infection. However, the current... Continue Reading →

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Outcomes of short versus long duration of antibiotic therapy for residual osteomyelitis in surgically resected diabetic foot infection #ActAgainstAmputation @ALPSlimb

More data (this report from Motaganahalli and coworkers to support the likely contention that, in general, shorter may be better - or at very least not worse. Introduction: Optimal treatment duration for residual osteomyelitis (OM) post-amputation in diabetic foot infection (DFI) remains unclear, with resultant heterogeneity in prescribing noted in clinical practice. We aimed to identify... Continue Reading →

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Smart Wearable Systems for the Remote Monitoring of Selected Vascular Disorders of the Lower Extremity: A Systematic Review #C2SHiP #Wearable #Diagnostic #Theragnostic

A good contribution from Souza and coworkers This systematic review aims at providing an overview of the state of the art regarding smart wearable systems (SWS) applications to monitor the status of patients suffering from vascular disorders of the lower extremity. Peer-reviewed literature has been analyzed to identify employed data collection methods, system characteristics, and... Continue Reading →

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