Author: David G. Armstrong

Dedicated to amputation prevention, wound healing, diabetic foot, biotechnology and the intersection between medical devices and consumer electronics.

Evaluating the prognostic performance of bedside tests used for peripheral arterial disease diagnosis in the prediction of diabetic foot ulcer healing

Evaluating the prognostic performance of bedside tests used for peripheral arterial disease diagnosis in the prediction of diabetic foot ulcer healing - Great work from our colleagues from Imperial College, London. Evaluating the prognostic performance of bedside tests used for peripheral arterial disease diagnosis in the prediction of diabetic foot ulcer healing WHAT IS ALREADY... Continue Reading →

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Unmet needs in diabetes-related foot ulcer (DFU) treatment

Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes, affecting approximately 34% of people with the disease. Despite advancements in treatment, there are still several unmet needs in the care of diabetic foot ulcers that can lead to poor outcomes, including prolonged healing time, infection, hospitalization, and amputation. Some of the key... Continue Reading →

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Fragile Feet and Trivial Trauma: Communicating the Etiology of Diabetic Foot Ulcers to Patients @JAPMAfeettweets

Our toemigos Gustav Jarl, Jaap van Netten, and Peter Lazzarini with another important contribution Patients with a high risk for diabetic foot ulcers often have a limited understanding of the complex etiology of the condition, which can hinder effective self-care. The Fragile Feet & Trivial Trauma model proposes a simplified approach to explain the risk... Continue Reading →

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Three Blinded Adjudicators: Minimizing bias in a diabetic foot ulcer clinical evaluation

This three blinded adjudicator model is one we've been using for several years in recent RCTs. Congrats to our amigos Paul Glat, Lisa Gould, Lael Pickett, and Doug Arm for putting it out there for publication and ultimately iteration. This specific analysis was derived from the HIFLO trial. Summary: The article discusses the steps taken... Continue Reading →

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Mechanisms of diabetic foot ulceration

Mechanisms of diabetic foot ulceration: A review Here's the summary of this manuscript by Deng and coworkers: • Diabetic foot ulcers (DFUs) are a serious complication of diabetes, with complex pathogenic factors. • Previous studies focused on diabetic peripheral vascular disease, neuropathy, and wound infections. • Researchers are now studying immune cells, endothelial cells, keratinocytes,... Continue Reading →

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New Study Reveals Racial Disparities in Treatment and Outcomes for Patients with Peripheral Artery Disease ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC @USC_vascular @ResearchatUSC @KeckSchool_USC

FOR IMMEDIATE RELEASE New Study Reveals Racial Disparities in Treatment and Outcomes for Patients with Peripheral Artery Disease Los Angeles, CA - March 10, 2023 - Researchers at the University of Southern California (USC) have published a new study in the journal Advanced Therapeutics revealing significant disparities in the treatment and outcomes for patients with... Continue Reading →

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Preliminary evaluation of dual-energy CT to quantitatively assess bone marrow edema in patients with diabetic foot ulcers and suspected osteomyelitis

Preliminary evaluation of dual‐energy CT to quantitatively assess bone marrow edema in patients with diabetic foot ulcers and suspected osteomyelitis Great work as usual from our Dutch compatriots Objectives The purpose of this study is to evaluate the value of dual-energy CT (DECT) with virtual non-calcium (VNCa) in quantitatively assessing the presence of bone marrow... Continue Reading →

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Level of 25-hydroxyvitamin D and vitamin D receptor in diabetic foot ulcer and factor associated with diabetic foot ulcers #ActAgainstAmputation @ALPSlimb

Tang and coworkers present these data. Bottom line: The study aimed to investigate the correlation between vitamin D deficiency and diabetic foot osteomyelitis (DFO) in patients with type 2 diabetes mellitus (T2DM) and diabetic foot ulcer (DFU). The levels of serum 25-hydroxyvitamin D [25(OH)VD] and vitamin D receptor (VDR) expression in wound margin tissues were... Continue Reading →

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Wound pH and Surface Temperature as a Predictive Biomarker of Healing in Diabetic Foot Ulcers #Diagnostic #Theragnostic #Thermometry #ActAgainstAmputation @ALPSLIMB

https://www.researchgate.net/publication/325190223_Continuous_Monitoring_of_Wound_Healing_Using_a_Wearable_Enzymatic_Uric_Acid_Biosensor

More supportive literature surround inflammation and wound pH Wound pH and Surface Temperature as a Predictive Biomarker of Healing in Diabetic Foot Ulcers - Bhavani Prasad Mahindrakar, Aakansha Giri Goswami, Farhanul Huda, Manisha Naithani, Somprakas Basu, 2023 This graphic from another manuscript (Roychoudhury and coworkers) DOI:10.1149/2.0231808jes Aim To monitor wound pH and surface temperature as... Continue Reading →

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