New Nationwide Study Finds Recurrence of Diabetic Foot Ulcers and Severe Peripheral Arterial disease Comparable to Cancer

FOR IMMEDIATE RELEASE Los Angeles, CA, July 23, 2025 — A new study published in the International Wound Journal highlights a striking parallel: the three-year recurrence rates for diabetic foot ulcers (DFU) and reintervention for chronic limb-threatening ischemia (CLTI) are comparable to—or exceed—those of advanced-stage cancers, including colorectal, breast, prostate, and even lung cancer. Led... Continue Reading →

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NIH-Funded SmartBoot Study Demonstrates Real-Time Remote Monitoring Breakthrough for Diabetic Foot Ulcer Healing @NIDDKgov @NIH #Wearables #ActAgainstAmputation @researchatusc @keckschool_usc @USC @UCLA

LOS ANGELES, CA, July 21, 2025 — A newly published study in Sensors introduces the first validated real-time remote monitoring system for patient adherence and mobility in diabetic foot ulcer (DFU) management. The system, called SmartBoot, leverages wearable edge computing and a cloud-connected platform to track step count, cadence, and boot adherence with unprecedented accuracy—marking a significant milestone in... Continue Reading →

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Serine, Stress, and Skin: A New Focus? @Cell_Metabolism #ActAgainstAmputation

A Nutrient-Driven Balancing Act: How Serine Tunes Stem Cell Fate in Skin Repair Novak et al., 2025, Cell Metabolism ⚖️ Serine, Stress, and Skin: A New Paradigm What if a single non-essential amino acid could pivot stem cells from regenerating hair to healing wounds? A striking new study from Elaine Fuchs’ group at Rockefeller University... Continue Reading →

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New Study Projects 360 Million Cases of Peripheral Artery Disease by 2050, Driven by Metabolic Risk and Aging #ActAgainstAmputation @researchatusc @alpslimb #CLTI #PAD

FOR IMMEDIATE RELEASE July 8, 2025 New Study Projects 360 Million Cases of Peripheral Artery Disease by 2050, Driven by Metabolic Risk and Aging Proactive Prevention Could Avert One in Three Cases Chongqing, Los Angeles — A landmark global study published today in Research (DOI: 10.34133/research.0702) projects a 220% increase in peripheral artery disease (PAD) cases worldwide by 2050,... Continue Reading →

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Save 2 feet in 3 minutes: The Three Minute Diabetic Foot Exam @ALPSlimb #ActAgainstAmputation

https://youtu.be/9zb2AZRCZUg We’re excited to share the launch of the ALPS 3-Minute Diabetic Foot Exam — a concise, evidence-based tool that equips healthcare professionals to identify patients at risk of diabetic foot complications in under three minutes. Why it matters:People with type 2 diabetes face increased risk of lower extremity amputation due to nerve damage and reduced blood... Continue Reading →

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A 50-Year-Old Tool Gets a Modern Makeover: #ActAgainstAmputation #PVR #PAD #CLTI #DiabeticFoot #WIfI

🚦Reclassifying Risk in the Diabetic Foot: Pulse Volume Recordings May Show Promise—And Ordinal Power In the ever-complex world of diabetic foot syndrome (DFS), detecting peripheral arterial disease (PAD) is as much about nuance as it is about numbers. A newly published study by Nützel et al. in Biomedicines brings us one step closer to clinical clarity by... Continue Reading →

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Get the Balance Right: How Much Pressure Is Too Much for the Diabetic Foot? #ActAgainstAmputation

When it comes to neuropathic (and likely neuroischemic) diabetic foot ulcers (DFUs), pressure and perfusion are often at odds. In an elegant study, Zhang and colleagues from Fudan University and Shanghai Jiao Tong University have quantified how the skin’s microcirculation responds to physiologic, gait-like pressure—and when that response begins to fail . 🚶‍♂️Walking the Line: Pressure... Continue Reading →

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Turning Back the Genetic Clock: Reactivating Organ Regeneration in Mammals – and the role of this molecule #Science

What if we could coax a mouse—or even a human—to regrow part of an ear? A study published this week in Science by Lin, Jia, Shi, He, Wang, and colleagues suggests that such a possibility may be closer than we think. In a landmark comparative genomics and transcriptomics study, the team identifies a dormant genetic switch that,... Continue Reading →

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Can GLP-1 Receptor Agonists Help Prevent Amputations? A New National Study from USC Suggests Yes @KeckSchool_USC @USC_Vascular @ALPSlimb #ActAgainstAmputation

GLP‑1 Receptor Agonists and Limb Outcomes: What a 645,000‑Patient Study Tells Us A nationwide retrospective cohort analysis published this week in Diabetes Care explores whether glucagon‑like peptide‑1 receptor agonists (GLP‑1 RAs) confer advantages over sodium–glucose cotransporter‑2 inhibitors (SGLT2i) for lower‑extremity events in type 2 diabetes. Led by Dr Tze‑Woei Tan, the investigation examined 645,121 individuals newly started on either drug class between... Continue Reading →

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Wisdom from Wounds: Armstrong Headlines Diabetic Foot Congress with Keynote Honoring Sjef van Baal in the Netherlands @alpslimb #ActAgainstAmputation

Almelo, Netherlands – June 2025 — In a powerful and thought-provoking keynote at Congres Diabetische Voet 2025, Prof. David G. Armstrong—Founding President of the American Limb Preservation Society (ALPS) and Distinguished Professor of Surgery and Neurological Surgery at USC—delivered the lecture named in honor of the symposium’s founder, Prof. Sjef van Baal. Armstrong’s plenary, titled “Limb Preservation: Looking... Continue Reading →

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