ROCHESTER, MN – February 25, 2025 – Professor David G. Armstrong, DPM, MD, PhD, renowned expert in limb preservation and diabetic foot care, has become the first podiatric surgeon to deliver Medicine Grand Rounds at the prestigious Mayo Clinic in Rochester. Prof. Armstrong’s historic presentation, titled "Looking Back to Look Forward: Tissue Repair, Wound Healing,... Continue Reading →
A First RCT for Calcium Sulfate Pellets in Diabetic Foot Osteomyelitis Treatment: The BIG D-FOOT Study #ActAgainstAmputation
Diabetic foot osteomyelitis (DFO) is a formidable challenge in limb preservation, often leading to major amputations and significant morbidity. Systemic antibiotic treatments are fraught with limitations—poor tissue penetration due to peripheral arterial disease, risks of systemic toxicity, and antibiotic resistance. But what if we could deliver antibiotics exactly where they are needed most? A groundbreaking randomized controlled... Continue Reading →
@USC Names David G. Armstrong a Distinguished Professor
LOS ANGELES — The University of Southern California has named Dr. David G. Armstrong, a global leader in diabetic limb preservation and surgery, a Distinguished Professor in recognition of his pioneering contributions to research, clinical care, and interdisciplinary innovation. Dr. Armstrong, Professor of Surgery and Neurological Surgery at USC, has authored more than 710 peer-reviewed papers and leads the university’s NSF-funded Center... Continue Reading →
Imagine: A Smart Reactive Hydrogel To Revolutionize Diabetic Wound Healing #MMP9 #Inflammation #CompanionDiagnostic #ActAgainstAmputation
Diabetic wounds present one of the most complex and persistent challenges in modern medicine, often leading to prolonged inflammation and impaired healing. A recent study by Meng et al. (2025) introduces a potentially groundbreaking solution: a smart, MMP-9-responsive hydrogel that releases M2 macrophage-derived exosomes (M2-Exos) in response to the inflammatory microenvironment of diabetic wounds. This innovation has the potential... Continue Reading →
Not All in Vein: Oral Antibiotics for Diabetic Foot Osteomyelitis #ActAgainstAmputation @USC_Vascular @researchatusc @KeckSchool_USC @LimbsandLungs
A growing body of evidence suggests that oral antibiotics may be as effective as intravenous (IV) therapy for treating diabetic foot osteomyelitis (DFO)—a severe and limb-threatening infection commonly associated with diabetic foot ulcers. Traditionally, IV antibiotics have been the gold standard, but a newly published narrative review from our combined team in the Journal of... Continue Reading →
Physicians Are Healing Themselves—A Reflection on @GinaKolata NYT Article and Our Colleague, Prof. John Buse
Screenshot In a recent New York Times article, Gina Kolata explores a striking trend in modern medicine: physicians, particularly in cardiology and endocrinology, are increasingly turning to GLP-1 receptor agonists like Ozempic, Wegovy, and Zepbound—not just for their patients, but for themselves. The piece highlights how these medications, initially designed to manage diabetes, are now being embraced by medical professionals... Continue Reading →
Bridging the Gap From Healing to Remission: Best Practices for Offloading in Diabetic Foot Care– Data from Lazzarini and Van Netten #ActAgainstAmputation @ALPSlimb #Remission
Diabetes-related foot disease (DFD) affects an estimated 200 million people globally, surpassing the disease burden of conditions like stroke and breast cancer. In their comprehensive article, Best Practice Offloading Treatments for Diabetic Foot Ulcer Healing, Remission, and Better Plans for the Healing-Remission Transition (Seminars in Vascular Surgery, 2025), Dr. Peter Lazzarini and Dr. Jaap J. van Netten examine the current state... Continue Reading →
WIfI in under 60 seconds- Wound, Ischemia, Foot infection and limb threat #ActAgainstAmputation
https://www.youtube.com/watch?v=zeXVMxy6k30 Thanks to Magdalena Antoszewska for her wizardry in putting together this video. Here's to working to #ActAgainstAmputation For more on this blog (there's quite a lot) see below for a sample. 3 rings of risk WIFI plus Function Evolution of WIfI: Expansion of WIfI Notation After Intervention #ActAgainstAmputation @alpslimb @vascularsvs @USC_vascular @UCSFVascular @jmills1955 @VirginiePhD_POD... Continue Reading →