Predicting Success in Spinal Cord Stimulation for the Diabetic Foot: The Role of Infrared Thermography

Spinal cord stimulation (SCS) has been an emerging therapy for patients with intractable ischemic pain and non-healing diabetic foot complications. While traditionally used for pain relief, evidence is building that SCS may also enhance blood flow, support ulcer healing, and even prolong limb salvage. But the critical question remains: who benefits most from this expensive... Continue Reading →

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Delphi-2M: An AI Model for Predicting Future Disease Trajectories

A team of researchers has introduced Delphi-2M, a generative artificial intelligence model trained to forecast an individual’s risk of developing more than 1,000 diseases years into the future. Built on transformer architecture similar to GPT, Delphi-2M was trained on the longitudinal health records of more than 500,000 participants in the UK Biobank and validated on... Continue Reading →

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Beyond Sole Salvation: Prolonging Life Through Multidisciplinary Limb Preservation #ActAgainstAmputation @JVascSurg @ALPSLimb

When we speak of limb salvage, it is easy to think only in terms of preventing amputation. But as new evidence makes clear, the story does not end at the ankle. It is not just about preserving the limb—it is about extending life and helping people stay active, engaged, and moving. In a recent study,... Continue Reading →

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Borate-Based Bioactive Glass Demonstrates Healing Benefit in Diabetic Foot Ulcers in Randomized Controlled Trial #ActAgainstAmputation

A new multicenter randomized controlled trial (RCT) from our combined team, published in the International Wound Journal, has reported that a borate-based bioactive glass fiber matrix (BBGFM) appears to significantly improve healing outcomes in people with chronic, non-healing non-infected, non-ischemic full-thickness diabetic foot ulcers (DFUs). Study Design The trial enrolled 148 participants across 14 U.S.... Continue Reading →

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David G. Armstrong Delivers Keynote at the 19th International Wound Healing Congress (AMCICHAC) in León, Mexico #ActAgainstAmputation @ALPSlimb

Armstrong with Profs Marta Zavala, Gerardo Morales and Eduardo Camacho following Armstrong’s Keynote León, Mexico – September 2025 – David G. Armstrong, Distinguished Professor of Surgery and Neurological Surgery at the University of Southern California, delivered a keynote lecture this morning at the 19th International AMCICHAC Congress, one of Latin America’s premier scientific meetings dedicated... Continue Reading →

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Teamwork Saves Limbs: BEST-CLI Analysis Highlights Power of Multidisciplinary Care #ActAgainstAmputation @ALPSlimb @BEST_CLI

A new publication from our multinational BEST-CLI collaboration, now in the Journal of Vascular Surgery, underscores a simple but powerful truth: patients with chronic limb-threatening ischemia (CLTI) do better when they are treated by a team. Why This Matters CLTI is the most advanced form of peripheral artery disease, often affecting people with diabetes and... Continue Reading →

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When Stress Doesn’t Tell the Whole Story: Walking Speed, Pre-Ulcers, and the Path to Prevention #ActAgainstAmputation #DiabeticFootUlcer

For decades, clinicians and researchers have sought a simple, reliable biomechanical predictor of diabetic foot ulceration. Peak plantar pressure has been the standard metric, but its predictive value has always been modest. A newer, more holistic measure—cumulative plantar tissue stress (CPTS)—was thought to offer better predictive power by integrating multiple factors: plantar pressure, time spent... Continue Reading →

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Silent and sinister: High Prevalence of Silent, Severe Coronary Ischemia in Patients with Diabetic Foot Ulcers: New Research Insights @farkomd @jvascsurg @alpslimb

A new manuscript published in the Journal of Vascular Surgery sheds light on the alarming prevalence of silent, severe coronary ischemia in patients with diabetic foot ulcers (DFU). The study, “High Prevalence of Silent, Severe Coronary Ischemia in Patients with Diabetic Foot Ulcers,” demonstrates that a significant proportion of DFU patients—without overt history of coronary artery... Continue Reading →

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Machine Learning to Diagnose Complications of #Diabetes #AI/ML

A new manuscript in the Journal of Diabetes Science and Technology from our global team explores how machine learning is being used to detect, diagnose, and even predict complications of diabetes. The paper, authored by Agatha Scheideman, Mandy Shao, Henry Zelada, Jorge Cuadros, Joshua Foreman, Pinaki Sarder, Cindy Ho, Niels Ejskjaer, Jesper Fleischer, Simon Lebech... Continue Reading →

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When Noncommunicable Diseases Overtook the World: Where We Stand Today and a Peek into the Future #NCDs #Lancet

Probability of dying from a non communicable disease: Change between 2010 and 2020, worldwide For much of human history, infectious diseases, maternal and neonatal conditions, and nutritional deficiencies defined the leading edge of mortality. Plagues, diarrheal disease, and tuberculosis were the archetypal killers. By contrast, noncommunicable diseases (NCDs)—heart disease, cancer, diabetes, chronic lung disease—were rare,... Continue Reading →

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