Tag: amputation

A Foot Ulcer Is a Whole-Body Diagnosis: New 5698 Patient Cohort Puts DFU Survival Back in the Cancer Conversation — But There’s Hope #DiabeticFoot #ActAgainstAmputation #ToeandFlow

A new 5,698-patient real-world cohort from Valladolid (Del Río-Solá et al., Adv Wound Care 2026) reports 61.8% five-year survival overall, falling to 32.1% after major amputation — and concludes the diabetic foot ulcer should be treated as a marker of advanced systemic disease, not an isolated wound. The newest entry in a fifteen-year line of evidence putting DFU mortality squarely in the cancer conversation.

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Hiding in Plain Sight: The #MedicareShoeBill Is Our Most Underused Lifesaver #ActAgainstAmputation @alpslimb

Ninety percent of clinicians know about the Medicare Therapeutic Shoe Benefit and nearly all recommend shoes, yet fewer than one in five eligible patients ever gets them. A new study from Ryan Crews and Carol Kurth shows the bottleneck isn't awareness. It's friction.

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Malvern at 40, and 30 Years On: One Last Bow for Profs. Boulton and Rayman, and a Long Road Ahead #Malvern40 #ActAgainstAmputation #DFCon #LimbPreservation @ALPSLimb

Forty years of the Malvern Diabetic Foot Meeting. Thirty years of mine. One last bow from Andrew Boulton in the chair. A look back at the long arc — from a Benedictine priory in 1085 to Joslin in 1928 to DFCon in 2000 to ALPS in 2020 — and a look forward to DFCon 26, DFUpdate, traveling fellowships, and the next generation already climbing the hill.

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From Scar to Salamander? Adult Mice Regrow Amputated Digits After Sequential FGF2 → BMP2 #regeneration #amputation @NatureComms

Yu and colleagues from Ken Muneoka's group show that sequential FGF2 then BMP2 treatment flips an adult mouse digit amputation from fibrosis to regeneration — rebuilding the distal phalanx with a growth plate, plus a parallel response that regenerates a synovial joint complex with tendon, ligament, and a sesamoid-like bone. The regeneration-competent cells are already in our wound beds. We just have to learn what to say to them.

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Mönckeberg: How a Quiet 1903 Autopsy Became the Loudest Plain Film in Limb Preservation #DiabeticFoot #PAD #CLTI #LimbPreservation #ActAgainstAmputation #PMAC #Calcification

Johann Georg Mönckeberg was a Hamburg patrician, born in 1877. His father — same name — was a senator of the free city, with the Mönckebergstrasse running from the Rathaus to the Hauptbahnhof named after him. The son grew up in a household where the name was already on the streets. He studied medicine at... Continue Reading →

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“Spooky Action at a Distance”: The Most Comprehensive Review Yet of Physiologic Neuromodulation for Limb Preservation #ActAgainstAmputation #Neuromodulation #SpinalCordStimulation #CLTI @BurnsTrauma @KeckSchool_USC @ResearchatUSC @USC

Our new paper in Burns and Trauma presents the most comprehensive review yet of spooky action at a distance therapies for diabetic limb preservation — from spinal cord stimulation and splenic ultrasound to remote ischemic conditioning and tibial transport. Five modalities, three mechanistic pathways, one shared destination: tissue repair at a distance.

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You Are What You Eat — And That’s Pretty Inflammatory: A New Composite Biomarker for DFU Risk #ActAgainstAmputation #DFU #Nutrition @ALPSLimb

A novel inflammation-nutrition biomarker — the neutrophil percentage-to-albumin ratio (NPAR) — shows strong association with diabetic foot ulcer risk in a 1,002-patient study from Xi'an, China, reinforcing that what patients eat and how they inflame are inseparable in the diabetic foot.

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From Foot to Fatality: The #DiabeticFootAttack Is Real, and It’s Worse Than You Think @alpslimb #ActAgainstAmputation

A new single-center study from the Netherlands quantifies the devastating outcomes of the diabetic foot attack: only 48.5% wound closure, 46% major amputation by 12 months, 26% one-year mortality, and 12-month amputation-free survival of just 39.7%. Time is tissue.

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25 Years of Plantar Pressure Research in #DiabeticFoot Ulcers: A Bibliometric Deep Dive @MDABORATORY #ActAgainstAmputation

A new bibliometric analysis from Wei and colleagues at Capital Medical University in Beijing maps 25 years (2000–2024) of global research on plantar pressure and diabetic foot ulcers — over 2,100 publications indexed in the Web of Science Core Collection. The findings tell a story that will feel familiar to many of us who have... Continue Reading →

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Limb Preservation: The Global State of Play in 2026 — Keynote at ADFA’s Inaugural Meeting in Paris #ActAgainstAmputation @ALPSLimb #DiabeticFoot #LimbPreservation #Paris

Honored to deliver the keynote at the inaugural meeting of ADFA in Paris.

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