Tag: amputation

From Scar to Salamander? Adult Mice Regrow Amputated Digits After Sequential FGF2 → BMP2 #regeneration #amputation @NatureComms

Yu and colleagues from Ken Muneoka's group show that sequential FGF2 then BMP2 treatment flips an adult mouse digit amputation from fibrosis to regeneration — rebuilding the distal phalanx with a growth plate, plus a parallel response that regenerates a synovial joint complex with tendon, ligament, and a sesamoid-like bone. The regeneration-competent cells are already in our wound beds. We just have to learn what to say to them.

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Mönckeberg: How a Quiet 1903 Autopsy Became the Loudest Plain Film in Limb Preservation #DiabeticFoot #PAD #CLTI #LimbPreservation #ActAgainstAmputation #PMAC #Calcification

Johann Georg Mönckeberg was a Hamburg patrician, born in 1877. His father — same name — was a senator of the free city, with the Mönckebergstrasse running from the Rathaus to the Hauptbahnhof named after him. The son grew up in a household where the name was already on the streets. He studied medicine at... Continue Reading →

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“Spooky Action at a Distance”: The Most Comprehensive Review Yet of Physiologic Neuromodulation for Limb Preservation #ActAgainstAmputation #Neuromodulation #SpinalCordStimulation #CLTI @BurnsTrauma @KeckSchool_USC @ResearchatUSC @USC

Our new paper in Burns and Trauma presents the most comprehensive review yet of spooky action at a distance therapies for diabetic limb preservation — from spinal cord stimulation and splenic ultrasound to remote ischemic conditioning and tibial transport. Five modalities, three mechanistic pathways, one shared destination: tissue repair at a distance.

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You Are What You Eat — And That’s Pretty Inflammatory: A New Composite Biomarker for DFU Risk #ActAgainstAmputation #DFU #Nutrition @ALPSLimb

A novel inflammation-nutrition biomarker — the neutrophil percentage-to-albumin ratio (NPAR) — shows strong association with diabetic foot ulcer risk in a 1,002-patient study from Xi'an, China, reinforcing that what patients eat and how they inflame are inseparable in the diabetic foot.

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From Foot to Fatality: The #DiabeticFootAttack Is Real, and It’s Worse Than You Think @alpslimb #ActAgainstAmputation

A new single-center study from the Netherlands quantifies the devastating outcomes of the diabetic foot attack: only 48.5% wound closure, 46% major amputation by 12 months, 26% one-year mortality, and 12-month amputation-free survival of just 39.7%. Time is tissue.

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25 Years of Plantar Pressure Research in #DiabeticFoot Ulcers: A Bibliometric Deep Dive @MDABORATORY #ActAgainstAmputation

A new bibliometric analysis from Wei and colleagues at Capital Medical University in Beijing maps 25 years (2000–2024) of global research on plantar pressure and diabetic foot ulcers — over 2,100 publications indexed in the Web of Science Core Collection. The findings tell a story that will feel familiar to many of us who have... Continue Reading →

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Limb Preservation: The Global State of Play in 2026 — Keynote at ADFA’s Inaugural Meeting in Paris #ActAgainstAmputation @ALPSLimb #DiabeticFoot #LimbPreservation #Paris

Honored to deliver the keynote at the inaugural meeting of ADFA in Paris.

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Control-Alt-Delete: Rebooting the Chronic Wound #ActAgainstAmputation #DFU #WoundHealing @ALPSLimb @KeckSchool_USC @USC_Vascular

Chronic wounds are biological computers stuck in a boot loop. Sharp debridement is Control-Alt-Delete — the histological reboot that converts a chronic wound back into an acute one. Only then can you run the apps.

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The ZIP Code Lottery: 15 Years of Evidence, One Solvable Crisis #ActAgainstAmputation

In 2009, California hospitals collectively documented 7,973 lower-extremity amputations in diabetic adults. Dr. Carl Stevens at Harbor-UCLA decided to ask a question most people in medicine had quietly avoided: where do these patients live? The answer, published five years later in Health Affairs, was the kind of finding that is simultaneously obvious in retrospect and... Continue Reading →

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Insurance Matters: Medicaid Coverage Linked to Higher Rates of Diabetic Foot Infection and Amputation #ActAgainstAmputation @USC_Vascular @ResearchatUSC @ALPSlimb

A new study from our USC group shows Medicaid patients with diabetic foot ulcers face 18% higher odds of infection hospitalization and 72% higher odds of major amputation — despite being younger and having comparable comorbidity burden after matching. The data point to structural vulnerability, not biology.

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