Tag: amputation

“Spooky Action at a Distance”: The Most Comprehensive Review Yet of Physiologic Neuromodulation for Limb Preservation #ActAgainstAmputation #Neuromodulation #SpinalCordStimulation #CLTI @BurnsTrauma @KeckSchool_USC @ResearchatUSC @USC

Our new paper in Burns and Trauma presents the most comprehensive review yet of spooky action at a distance therapies for diabetic limb preservation — from spinal cord stimulation and splenic ultrasound to remote ischemic conditioning and tibial transport. Five modalities, three mechanistic pathways, one shared destination: tissue repair at a distance.

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You Are What You Eat — And That’s Pretty Inflammatory: A New Composite Biomarker for DFU Risk #ActAgainstAmputation #DFU #Nutrition @ALPSLimb

A novel inflammation-nutrition biomarker — the neutrophil percentage-to-albumin ratio (NPAR) — shows strong association with diabetic foot ulcer risk in a 1,002-patient study from Xi'an, China, reinforcing that what patients eat and how they inflame are inseparable in the diabetic foot.

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From Foot to Fatality: The #DiabeticFootAttack Is Real, and It’s Worse Than You Think @alpslimb #ActAgainstAmputation

A new single-center study from the Netherlands quantifies the devastating outcomes of the diabetic foot attack: only 48.5% wound closure, 46% major amputation by 12 months, 26% one-year mortality, and 12-month amputation-free survival of just 39.7%. Time is tissue.

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25 Years of Plantar Pressure Research in #DiabeticFoot Ulcers: A Bibliometric Deep Dive @MDABORATORY #ActAgainstAmputation

A new bibliometric analysis from Wei and colleagues at Capital Medical University in Beijing maps 25 years (2000–2024) of global research on plantar pressure and diabetic foot ulcers — over 2,100 publications indexed in the Web of Science Core Collection. The findings tell a story that will feel familiar to many of us who have... Continue Reading →

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Limb Preservation: The Global State of Play in 2026 — Keynote at ADFA’s Inaugural Meeting in Paris #ActAgainstAmputation @ALPSLimb #DiabeticFoot #LimbPreservation #Paris

Honored to deliver the keynote at the inaugural meeting of ADFA in Paris.

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Control-Alt-Delete: Rebooting the Chronic Wound #ActAgainstAmputation #DFU #WoundHealing @ALPSLimb @KeckSchool_USC @USC_Vascular

Chronic wounds are biological computers stuck in a boot loop. Sharp debridement is Control-Alt-Delete — the histological reboot that converts a chronic wound back into an acute one. Only then can you run the apps.

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The ZIP Code Lottery: 15 Years of Evidence, One Solvable Crisis #ActAgainstAmputation

In 2009, California hospitals collectively documented 7,973 lower-extremity amputations in diabetic adults. Dr. Carl Stevens at Harbor-UCLA decided to ask a question most people in medicine had quietly avoided: where do these patients live? The answer, published five years later in Health Affairs, was the kind of finding that is simultaneously obvious in retrospect and... Continue Reading →

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Insurance Matters: Medicaid Coverage Linked to Higher Rates of Diabetic Foot Infection and Amputation #ActAgainstAmputation @USC_Vascular @ResearchatUSC @ALPSlimb

A new study from our USC group shows Medicaid patients with diabetic foot ulcers face 18% higher odds of infection hospitalization and 72% higher odds of major amputation — despite being younger and having comparable comorbidity burden after matching. The data point to structural vulnerability, not biology.

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Beyond Sole Salvation: Prolonging Life Through Multidisciplinary Limb Preservation #ActAgainstAmputation @JVascSurg @ALPSLimb

When we speak of limb salvage, it is easy to think only in terms of preventing amputation. But as new evidence makes clear, the story does not end at the ankle. It is not just about preserving the limb—it is about extending life and helping people stay active, engaged, and moving. In a recent study,... Continue Reading →

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🧠 The Phantom Persists: Brain Maps Stay Intact After Amputation

Contrary to long-standing assumptions about massive cortical reorganization following limb loss, this longitudinal study reveals that the brain’s somatosensory map is far more stable than previously believed. 🔍 Study Design: A Rare Longitudinal Window While past research on cortical reorganization often relied on cross-sectional comparisons between amputees and controls, this study by Schone et al. took a... Continue Reading →

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