On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
Chronic wounds are biological computers stuck in a boot loop. Sharp debridement is Control-Alt-Delete โ the histological reboot that converts a chronic wound back into an acute one. Only then can you run the apps.
Tiny Robots, Big Gains: Is Nanobotics the Future of Limb Salvage? The "holy grail" of wound healing has always been a treatment that doesn't just sit on the wound but actively works within it. Traditional dressingsโeven the fancy onesโare largely passive barriers. But a groundbreaking review recently published in the International Journal of Nanomedicine suggests... Continue Reading →
Biofilms are the silent drivers of chronicity in diabetic foot ulcers (DFUs). We talk about them constantly. We blame them for stalled healing. But when you peel back the layers of current literature, how much hard clinical evidence do we actually have that our interventions are destroying them? In our latest systematic review, published in... Continue Reading →
Weโve long been told to take our vitaminsโbut recent research suggests we might also want to โprescribeโ them directly to our most persistent microbial adversaries. A striking 2025 study published in BMC Microbiology reveals that vitamin C (sodium ascorbate) may do more than bolster immune function: it can weaken drug-resistant bacterial biofilms and restore the efficacy of... Continue Reading →
In the complex world of wound care, innovation often finds inspiration in nature. Nitric oxide (NO), a simple yet potent molecule, is gaining recognition for its remarkable antimicrobial and antibiofilm properties. A recent review by Roberts et al.,ย Harnessing the Power of Our Immune System: The Antimicrobial and Antibiofilm Properties of Nitric Oxide, highlights the growing... Continue Reading →
Here is a copy of a preprint from our long-time friend and colleague Eric Senneville and coworkers. The choice of antibiotic regimens to use in patients presenting with diabetic foot osteomyelitis and their duration differs according to the situation. Antibiotics play a more important role in the medical option where no infected bone has been... Continue Reading →
Important work from our Danish and Aussie colleagues Abstract Background and purpose: Clinicians and researchers utilize subjective, clinical classification systems to stratify lower extremity ulcer infections for treatment and research. The purpose of this study was to examine whether these clinical classifications are reflected in the ulcer's transcriptome. Methods: RNA-sequencing (RNA-seq) was performed on biopsies from clinically... Continue Reading →
Crowther and coworkers publish this work in Antimicrobial Agents and Chemotherapy lending further strength to the goal of maximizing antimicrobial therapy at the site of infection. Diabetic foot ulcers are notoriously difficult to heal, with ulcers often becoming chronic, in many cases leading to amputation despite weeks or months of antibiotic therapy in addition to... Continue Reading →
