Tag: CLTI

“Spooky Action at a Distance”: The Most Comprehensive Review Yet of Physiologic Neuromodulation for Limb Preservation #ActAgainstAmputation #Neuromodulation #SpinalCordStimulation #CLTI @BurnsTrauma @KeckSchool_USC @ResearchatUSC @USC

Our new paper in Burns and Trauma presents the most comprehensive review yet of spooky action at a distance therapies for diabetic limb preservation — from spinal cord stimulation and splenic ultrasound to remote ischemic conditioning and tibial transport. Five modalities, three mechanistic pathways, one shared destination: tissue repair at a distance.

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The “Iron Curtain” of the Foot: More Insights into Arterial Obstruction in CLTI #ActAgainstAmputation #PAD #DiabeticFoot

When we talk about Chronic Limb-Threatening Ischemia (CLTI), we often focus on what we can see on an angiogram. But what is actually happening inside those vessels at a microscopic level? A comprehensive histopathological analysis of amputated limbs is shedding new light on the specific patterns of arterial obstruction that lead to limb loss. This... Continue Reading →

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🩸 PET Scans Reveal Localized Hyper-Perfusion in Diabetic Foot Ulcers #ActAgainstAmputation

Understanding the Vascular Dynamics of DFU Healing and Pathology A recent study published in the Journal of Clinical Medicine by Christensen et al. (2025) utilized Oxygen-15 Labeled Water PET imaging to investigate resting skeletal muscle perfusion in patients with Type 2 Diabetes Mellitus (T2DM) and diabetic foot ulcers (DFUs), comparing them to healthy controls. This... Continue Reading →

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Gene Therapy Emerges as a Potentially New Tool in Wound Healing for People with Vascular Disease: The LEGenD-1 Trial

Published today in Circulation: Cardiovascular Interventions, the LEGenD-1 trial represents a step toward a potential milestone in regenerative medicine and limb preservation. The study, titled “Anatomically Directed Lower Extremity Gene Therapy for Ulcer Healing: A Double-Blind, Randomized, Placebo-Controlled Study,” demonstrates that gene therapy can safely potentially accelerate wound healing in patients with chronic limb-threatening ischemia... Continue Reading →

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Inflammation, Lipids, and Limb Risk: New Clues from Two Cohorts #ActAgainstAmputation #PAD #VascularDisease #CLTI

Peripheral artery disease (PAD) is one of the most devastating complications of diabetes—contributing to ischemic pain, functional decline, and, in severe cases, amputation. Despite its prevalence, early detection remains elusive, and clinicians continue to search for simple, reliable markers of risk. A new multicohort study led by Wang and colleagues now shines a spotlight on... Continue Reading →

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When Science Becomes Family: A Conversation on DFU, CLTI, and Recurrence Risk

It’s not every day that the professional and the personal intersect in such a deeply life-affirming way. Our latest publication in the International Wound Journal, “Three-Year Recurrence in People With Diabetic Foot Ulcers and Chronic Limb Threatening Ischemia Is Comparable to Cancer,” brought together an extraordinary team of colleagues from UCSF, Baylor College of Medicine, USC,... Continue Reading →

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New Nationwide Study Finds Recurrence of Diabetic Foot Ulcers and Severe Peripheral Arterial disease Comparable to Cancer

FOR IMMEDIATE RELEASE Los Angeles, CA, July 23, 2025 — A new study published in the International Wound Journal highlights a striking parallel: the three-year recurrence rates for diabetic foot ulcers (DFU) and reintervention for chronic limb-threatening ischemia (CLTI) are comparable to—or exceed—those of advanced-stage cancers, including colorectal, breast, prostate, and even lung cancer. Led... Continue Reading →

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A Call to Action — By Congressional District: From the Amputation Heat Map @American_Heart #Diabetes @ALPSlimb #CLTI #ActAgainstAmputation

Making limb preservation a national priority- one congressional district at a time Does your congressman or congresswoman know where you are on the amputation heat map? That’s not just a rhetorical question. It’s a matter of life and limb. The American Heart Association’s PAD Collaborative has unveiled a powerful tool: an interactive map showing non-traumatic lower extremity amputation... Continue Reading →

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Further Exploring Tibial Periosteal Distraction as a Adjunct to Healing Diabetic Foot Ulcers

Diabetic foot ulcers (DFUs) represent one of the most significant challenges in managing diabetes-related complications. Affecting millions worldwide, DFUs lead to substantial morbidity, healthcare costs, and a heightened risk of amputation. While traditional therapies like debridement, offloading, and vascular interventions have their place, innovative solutions are crucial to improve outcomes. A recent study by Yuan... Continue Reading →

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Exploring the Prognostic Role of Toe Pressures in Diabetic Foot Ulcers with Medial Arterial Calcification #PAD #CLTI #Diagnostics #DiabeticFoot #ActAgainstAmputation

In the landscape of diabetic foot care, the presence of medial arterial calcification (MAC) adds a significant layer of complexity to the management of diabetic foot ulcers (DFUs). A recent study published in the Annals of Vascular Surgery sheds light on the prognostic value of toe pressure (TP) measurements in predicting outcomes for this challenging patient population.... Continue Reading →

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