Tag: CLTI

Exploring the Risks of SGLT2i vs. DPP-4i as Add-On Therapies in Diabetes Care #Amputation #PAD #CLTI #Stent #DiabetesCare

A new study published in Diabetes Care sheds light on the comparative risks of peripheral artery disease (PAD)-related surgical events—such as amputations, stent placements, or vascular surgeries—between two classes of diabetes medications: sodium-glucose cotransporter 2 inhibitors (SGLT2i) and dipeptidyl peptidase 4 inhibitors (DPP-4i). Conducted among U.S. veterans, this retrospective cohort study analyzed over 150,000 episodes of medication... Continue Reading →

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The Impact of Angiographic Pedal Circulation Status on Wound Healing in Chronic Limb-Threatening Ischemia After Bypass Surgery #ActAgainstAmputation #WoundHealing #WIFI

Miyake K, Kikuchi S, Uchida D, Doita T, Miyagawa S, Azuma N Understanding Pedal Circulation’s Role in CLTI Wound Healing In chronic limb-threatening ischemia (CLTI), achieving complete wound healing is critical for reducing morbidity and improving patient outcomes. Although the Global Limb Anatomic Staging System (GLASS) provides a robust framework for assessing CLTI severity, its... Continue Reading →

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Evaluating the Reliability of Portable Toe Pressure PPG Measurement Devices: Insights from Helsinki

The ability to accurately assess lower limb arterial circulation is critical in vascular medicine. A new study by Laamanen et al., from Maarit Venermo's unit published online in Vascular, evaluates the reliability of a portable toe pressure (TP) photoplethysmography (PPG) device compared to a stationary laser Doppler flowmeter (LD). This investigation sheds light on whether an... Continue Reading →

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Exploring Innovative Limb Salvage Techniques for CLTI – Tibial Cortex Transverse Transport (TTT) and Endovascular intervention

Introduction Chronic limb-threatening ischemia (CLTI) is a severe condition with high risks of amputation and mortality. A groundbreaking study by Ding et al. (2024) has revealed the potential of combining Tibial Cortex Transverse Transport (TTT) with Endovascular Therapy (EVT) to enhance outcomes for patients suffering from CLTI. Key Findings • At 6 months, 85.5% of... Continue Reading →

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Unveiling the Future of Diabetic Foot Care: The Promise of Wearable Laser Doppler Flowmetry #ActAgainstAmputation #Wearables #DiabeticFoot

Screenshot As the prevalence of Type 2 diabetes mellitus (T2DM) continues to rise globally, the need for innovative solutions to manage its complications becomes increasingly urgent. Diabetic foot (DF) is one of the most severe complications, often leading to ulcers, infections, and even amputations. Traditional methods for assessing foot microcirculation in diabetic patients are limited... Continue Reading →

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Drug-Eluting Resorbable Scaffold versus Angioplasty for Infrapopliteal Artery Disease #ActAgainstAmputation #CLTI

In the realm of peripheral artery disease, particularly infrapopliteal artery disease, the quest for effective treatment options has been ongoing. A recent study, published in the New England Journal of Medicine on October 25, 2023, sheds light on a promising approach that could significantly impact the management of chronic limb-threatening ischemia (CLTI) due to infrapopliteal... Continue Reading →

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From a Spark to a Flame: The Evolution of Diabetic Foot Disease in the Last Two Decades #DiabeticFoot #ActAgainstAmputation

The Evolution of Diabetic Foot Disease Over the Past Generation Diabetes-related foot complications have long been a significant health concern, but recent research from our friends and colleagues-- international experts Marco Meloni, Alberto Piaggesi, and Luigi Uccioli offers new insights into the evolution of diabetic foot disease (DFD) over the past two decades. Their comprehensive... Continue Reading →

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Liraglutide for Lower Limb Perfusion in People With Type 2 Diabetes: The STARDUST randomized clinical trial #PAD #CLTI

In an intriguing study published in JAMA Network Open, researchers have unveiled promising results regarding the treatment of peripheral artery disease (PAD) in individuals with type 2 diabetes. The study, titled "Liraglutide for Lower Limb Perfusion in People With Type 2 Diabetes and Peripheral Artery Disease: The STARDUST Randomized Clinical Trial," led by Paola Caruso,... Continue Reading →

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Relevance of BEST-CLI trial endpoints in a tertiary care limb preservation program

In a recent study conducted by a team from the University of California, San Francisco (UCSF), including Iris H. Liu, MD, Rym El Khoury, MD, Jade S. Hiramoto, MD MAS, Warren J. Gasper, MD, Peter A. Schneider, MD, Shant M. Vartanian, MD, and Michael S. Conte, MD, the relevance of the BEST-CLI trial endpoints was... Continue Reading →

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More on the Potentially Innovative Approach to Neuroischemic Diabetic Foot Ulcers: Modified Tibial Cortex Transverse Transport

Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes, often leading to lower extremity amputations. Traditional treatments, while varied, do not always prevent the progression of these ulcers, particularly in more advanced stages. However, a recent study published by Liu et al. offers hope through a novel surgical technique known as modified... Continue Reading →

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