Evaluation of Glycologic Point-of-Care Infection Test Kit for Diabetic Foot Ulcers in Relation to Bacterial Presence: A Prospective Cohort Study #ActAgainstAmputation @JAPMAfeettweets

This from our colleagues in Carlisle, UK. We see more chairside/bedside diagnostics and theragnostics to help measure what we manage. Background: Point-of-care testing for infection might help podiatric physicians optimize management of diabetic foot ulcers (DFUs). Glycologic's proprietary GLYWD product has been developed to detect changes in a patient's immunologic/inflammatory response related to wound infection. We... Continue Reading →

Routine bacterial culture of proximal bone specimens during minor amputation in patients with DFI has little clinical utility in predicting re-operation or healing @ALPSlimb #ActAgainstAmputation #DiabeticFoot

Bone cultures? Clean margins for pathology? Both? These data from Voon and colleagues add more fuel to the discussionBackground: Trans-phalangeal and trans-metatarsal amputation, collectively termed 'minor amputations' are important procedures for managing infections of diabetes-related foot ulcers (DFU). Following minor amputation, international guidelines recommend a prolonged course of antibiotics if residual infected bone on intra-operative... Continue Reading →

An in vivo model for overloading-induced soft tissue injury #ActAgainstAmputation #DiabeticFoot #Theragnostics #Diagnostics @ALPSlimb @Staffsbiomech

Strong work from our Staffordshire colleagues Chatzistergos and Chockalingam who continue to help push the envelope in helping us collectively measure what we manage. An in vivo model for overloading-induced soft tissue injury This proof of concept study demonstrates that repetitive loading to the pain threshold can safely recreate overloading induced soft tissue damage and... Continue Reading →

Site-Specific, Critical Threshold Barefoot Peak Plantar Pressure Associated with Diabetic Foot Ulcer History: A Novel Approach to Determine DFU Risk in the Clinical Setting @alpslimb

Site-Specific, Critical Threshold Barefoot Peak Plantar Pressure Associated with Diabetic Foot Ulcer History: A Novel Approach to Determine DFU Risk in the Clinical Setting Excellent, pragmatic work from our Mancunian colleagues, Caroline Abbott and coworkers. Background and Objectives: Barefoot peak plantar pressures (PPPs) are elevated in diabetes patients with neuropathic foot ulcer (DFU) history; however, there... Continue Reading →

Is a Left-to-Right >2.2°C Difference a Valid Measurement to Predict Diabetic Foot Ulceration in People in Diabetic Foot Remision? #Thermometry

Terrific work from Featherson and coworkers lending further light on the role (and limitations) of thermometry/thermography in predicting reulceration in diabetic foot remission Monitoring foot skin temperatures at home have been shown to be effective at preventing the occurrence of diabetic foot ulcers. In this study, the construct validity of using >2.2°C difference between contralateral... Continue Reading →

Skin autofluorescence for non-enzymatic glycation end products in Diabetic Foot Ulcers (DFUs)- A meta analysis

Continued efforts to create companion diagnostics and theragnostics to help us measure what we manage and predict DFU risk. Imagine diagnosing "friable" tissue and then doing something about it?! Objective: Skin autofluorescence (SAF) has been suggested as a novel and noninvasive technique for assessing tissue accumulation of advanced glycation end products in diabetes and related complications.... Continue Reading →

High-Resolution Spectral Analysis Accurately Identifies the Bacterial Signature in Infected Chronic Foot Ulcers in People With Diabetes

Will we soon see more visual diagnostics for wounds? Congratulations to our colleagues in Melbourne for these intriguing data. Diabetic foot infections are a major cause of hospitalization, and delayed treatment can lead to numerous complications. The aim of this research was to investigate high-resolution spectroscopy of the wound center and periwound area for real-time... Continue Reading →

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