Tag: diagnostics

A wound alkalinity measurement to predict non-healing wound outcomes: A literal litmus test #Diagnostics #Theragnostics #WoundHealiing #Diabetic Foot

Again, a literal litmus test to help guide therapy. From Senkowsky and coworkers in JWC More work can be found here and here and here and here (etc). Abstract Objective: As wound pH could influence wound healing rates, this study examined the alkalinity of the entire wound during patients' follow-up visits to predict the final non-healing... Continue Reading →

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Can Wound Surface pH and Temperature Predict Wound Healing in Diabetic Foot Ulcer? #Theragnostics #Diagnostics #DiabeticFootUlcer

More data supporting diagnostics and theragnostics like wound pH and thermometry. Introduction: Diabetic foot ulcer (DFU) is dreaded and one of the most intricate medical conditions in diabetes. Improving the healing of DFU is imperative for improved patient outcomes. To consider a biomarker of comprehensive value to patients and health care professionals, it should be cost... Continue Reading →

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The effect of inflammation management on pH, temperature, and bacterial burden #ActAgainstAmputation #WoundHealing

Important work from Derwin and coworkers in Zena Moore's group. The aim of this feasibility study was to investigate the impact of inflammation management on wound pH, temperature, and bacterial burden, using the principles of TIME and Wound Bed Preparation. A quantitative non-comparative, prospective, descriptive observational design. Following ethical approval, 26 participants with 27 wounds... Continue Reading →

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Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions #Theragnostics #Diagnostics @CSHL @UnivMiami

A great perspective from Pastar and coworkers from our long-time friend Marjana Tomic-Canic's lab at University of Miami published in Cold Spring Harbor Perspectives in Biology. Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds with multifactorial etiologies that are associated... Continue Reading →

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Bacterial Protease Activity (BPA) may reduce Hospitalization, Improve Quality of LIfe: RCT #Theragnostics #Diagnostics #ActAgainstAmputation

This published in the Journal of Wound Care Effectiveness of testing hard-to-heal wounds for bacterial protease activity: a randomised clinical trial The rapid lateral flow test for BPA is easy to perform, provides actionable results at the point-of-care, and is a useful diagnostic tool to assist wound care clinicians in evidence-based treatment decisions

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Factors Influencing the Risk of Major Amputation inPatients with Diabetic Foot Ulcers Treated by Autologous Cell Therapy @ALPSLimb #ActAgainstAmputation

Great work from our colleagues at IKEM and Manchester. Bottom line: Pay attention to CRP, polymorphisms to methylenetetrahydrofolate reductase (MTHFR) as well as low TCPO2 Key points: The aim of our study was to assess the risk factors for major amputation in patients with CLTI and DFU during a 2-year follow-up after ACT.One hundred and... Continue Reading →

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Bioinformatic Analysis Reveals Hub Immune-Related Genes of Diabetic Foot Ulcers #ActAgainstAmputation

This from Rong and coworkers Summary Points: Diabetic foot ulcer (DFU) is a complex and devastating complication of diabetes mellitus that are usually stagnant in the inflammatory phase.However, oral wound healing, which is characterized by a rapid and scarless healing process, is regarded an ideal model of wound healing.Thus, we performed a comprehensive bioinformatics analysis... Continue Reading →

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A Clinical Study to Evaluate Autofluorescence Imaging of Diabetic Foot Ulcers Using a Novel Artificial Intelligence Enabled Noninvasive Device #ActAgainstAmputation #DiabeticFoot

A Clinical Study to Evaluate Autofluorescence Imaging of Diabetic Foot Ulcers Using a Novel Artificial Intelligence Enabled Noninvasive Device Great work from our long-time friend and colleague Vijay Viswanathan and coworkers pushing diagnostics and theragnostics forward. Fluorescence of Bacteria Diabetic foot ulcers, with worldwide prevalence ranging from 12%-25%, are an important cause of nontraumatic lower... Continue Reading →

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Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay

Excellent work in diagnostics and theragnostics from Brunauer and coworkers in the journal Biosensors. Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay Abstract: The rapid detection of pathogens in infected wounds can significantly improve the clinical outcome. Wound exudate, which can be collected in a non-invasive way, offers an attractive... Continue Reading →

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SPECT-CT in the early diagnosis of Charcot arthropathy

More strong and practical work from our colleagues at King's... The Role of Bone Scintigraphy with SPECT/CT in the Characterization and Early Diagnosis of Stage 0 Charcot Neuroarthropathy Abstract: We describe the use of Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) in the investigation and diagnosis of Charcot neuroarthropathy (CN) in patients with a hot... Continue Reading →

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