A great perspective from Pastar and coworkers from our long-time friend Marjana Tomic-Canic’s lab at University of Miami published in Cold Spring Harbor Perspectives in Biology.
Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions
Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds with multifactorial etiologies that are associated with high patient morbidity and mortality. Despite considerable progress in deciphering the pathologies of chronic wounds using “omics” ap- proaches, considerable gaps in knowledge remain, and current therapies are often not effi- cacious. We provide a comprehensive overview of current understanding of the molecular mechanisms that impair healing and current knowledge on cell-specific dysregulation in- cluding keratinocytes, fibroblasts, immune cells, endothelial cells and their contributions to impaired reepithelialization, inflammation, angiogenesis, and tissue remodeling that charac- terize chronic wounds. We also provide a rationale for further elucidation of ulcer-specific pathologic processes that can be therapeutically targeted to shift chronic nonhealing to acute healing wounds.