Diabetic Peripheral Neuropathy Associated with Foot Ulcer: One of a Kind #ActAgainstAmputation #WoundHealing

Diabetic Peripheral Neuropathy Associated with Foot Ulcer: One of a Kind Compelling and insightful work from Chandan Sen and coworkers. Diabetic Peripheral Neuropathy Associated with Foot Ulcer: One of a Kind Significance: Diabetic peripheral neuropathy (DPN) associated with a diabetic foot ulcer (DFU) is likely to be complicated with critical factors such as biofilm infection... Continue Reading →

The Use of Point-of Care Bacterial Autofluorescence Imaging in the Management of Diabetic Foot Ulcers: A Pilot Randomized Controlled Trial #Diagnostics #Theragnostics

Important work from our SALSAmigos in Leeds. We see a slow and steady march toward companion diagnostics for our patients. Here we see fluorescence-guided debridement as an example of this. OBJECTIVE To estimate comparative healing rates and decision-making associated with the use of bacterial autofluorescence imaging in the management of diabetic foot ulcers (DFUs). RESEARCH... Continue Reading →

Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta‐analysis

Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis Here is an updated meta in what seems to be an avalanche of these for topical oxygen therapy. Xian-Kun Sun,Rao Li,Xiao-Ling Yang,Li Yuan To evaluate the efficacy and safety of topical oxygen therapy (TOT) in diabetic foot ulcers... Continue Reading →

Bioinformatic Analysis Reveals Hub Immune-Related Genes of Diabetic Foot Ulcers #ActAgainstAmputation

This from Rong and coworkers Summary Points: Diabetic foot ulcer (DFU) is a complex and devastating complication of diabetes mellitus that are usually stagnant in the inflammatory phase.However, oral wound healing, which is characterized by a rapid and scarless healing process, is regarded an ideal model of wound healing.Thus, we performed a comprehensive bioinformatics analysis... Continue Reading →

Chronic wounds: Treatment consensus @WoundHeal @alpslimb #ActAgainstAmputation #WoundHealing

Chronic wounds: Treatment consensus Elof Eriksson 1, Paul Y Liu 2, Gregory S Schultz 3, Manuela M Martins-Green 4, Rica Tanaka 5, Dot Weir 6, Lisa J Gould 7, David G Armstrong 8, Gary W Gibbons 9, Randy Wolcott 10, Oluyinka O Olutoye 11 12, Robert S Kirsner 13, Geoffrey C Gurtner 14 Up to date consensus on wound healing from an international interdisciplinary consensus committee published in Wound Repair and Regeneration. It was great fun to participate. Kudos to Lisa... Continue Reading →

New Insights on the Effects of Dietary Omega‐3 Fatty Acids on Impaired Skin Healing in DFU and VLU #DiabeticFoot #Wound Healing

A terrific review by Rome's Serini and Calviello Long-chain Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) are widely recognized as powerful negative regulators of acute inflammation. However, the precise role exerted by these dietary compounds during the healing process is still largely unknown, and there is increasing interest in understanding their specific effects on the implicated... Continue Reading →

Mixed up Macrophages: M1/M2 Dysregulation in Diabetic Foot Ulcers

A great review from Queensland that should help put some of the confusing M1-M2 phenotype story into sharper relief. Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds Abstract: Macrophages play a prominent role in wound healing. In the early stages, they promote inflammation and remove pathogens, wound debris, and cells that... Continue Reading →

Measuring progress to healing: A challenge and an opportunity – The value of wound margin advancement

Great, provocative work by our colleagues Prof. Keith Harding and coworkers. Use of the radius, rather than surface area or percent wound area reduction may be a way forward Advance of wound margin, rather than PWAR or gross area reduction may be a more consistent surrogate method to evaluate healing rate Complete healing is problematic... Continue Reading →

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