Tag: wound healing

The Role of GLUT3 in Macrophage Function: Implications for Diabetic Foot Wound Healing #ActAgainstAmputation

Introduction Glucose transporter 3 (GLUT3) is typically associated with neuron function and the transport of glucose across cell membranes. However, a recent study has indicated that GLUT3 also plays a critical role in macrophage signaling and function. This has considerable implications for atopic dermatitis and wound healing. The Study: A Brief Overview The research, titled... Continue Reading →

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The Diabetic Foot-Pain-Depression Cycle: Results from a Clinical Cohort #Depression #DiabeticFoot #Pain #ActAgainstAmputation #Diabetes

This work from our combined Dartmouth, SALSA USC and SMU team led by Brandon Brooks Abstract Background: More than 86,000 Americans with type 2 diabetes mellitus (T2DM) undergo nontraumatic lower-extremity amputations annually. The opioid-prescribing practice of podiatric surgeons remains understudied. We hypothesized that patients with T2DM who undergo any forefoot amputation while using antidepressant medication will... Continue Reading →

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Journal of the American Medical Association: Diabetic Foot Ulcers @JAMA_Current #ActAgainstAmputation #DiabeticFoot

From JAMA Armstrong, Tan, Boulton, and Bus, JAMA. 2023;330(1):62-75. doi:10.1001/jama.2023.10578 In diabetic foot disease, tissue loss,ischemia, and infection frequentlyoverlap. However, one is frequentlymore dominant than the other atdifferent times in the life cycle of anacute-on-chronic event. Here, theamount of tissue loss, ischemia, andfoot infection can be ordinally gradedto help predict outcome and assist incommunicating a plan... Continue Reading →

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Diabetic foot ulcers: weekly versus second weekly debridement: Study #ActAgainstAmputation #WoundHealing

Title: Diabetic Foot Ulcers: Weekly vs. Second-Weekly Conservative Sharp Wound Debridement Introduction:Diabetic foot ulcers (DFU) present a significant challenge in managing patients with diabetes, as they are both common and difficult to heal. Conservative sharp wound debridement (CSWD) is a vital component of DFU care, aimed at removing necrotic tissue and promoting healing. However, determining... Continue Reading →

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Breakthrough treatments for wound healing @scienceadvances #ActAgainstAmputation @alpslimb

This manuscript from Freeman and coworkers Skin injuries across the body continue to disrupt everyday life for millions of patients and result in prolonged hospital stays, infection, and death. Advances in wound healing devices have improved clinical practice but have mainly focused on treating macroscale healing versus underlying microscale pathophysiology. Consensus is lacking on optimal... Continue Reading →

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‘Smart’ Bandages Monitor Wounds and Provide Targeted Treatment @Caltech @USC ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC_vascular @ResearchatUSC @KeckSchool_USC

This release regarding a manuscript published by our combined Caltech/USC team led by our SALSAmigo, Wei Gao. Also see this from the Guardian newspaper. Summary: A recent study from Caltech and USC reports that smart bandages equipped with biosensors could significantly improve the healing process of chronic wounds. These high-tech bandages monitor wounds in real-time... Continue Reading →

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Three Blinded Adjudicators: Minimizing bias in a diabetic foot ulcer clinical evaluation

This three blinded adjudicator model is one we've been using for several years in recent RCTs. Congrats to our amigos Paul Glat, Lisa Gould, Lael Pickett, and Doug Arm for putting it out there for publication and ultimately iteration. This specific analysis was derived from the HIFLO trial. Summary: The article discusses the steps taken... Continue Reading →

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Allogenic Adipose-Derived Stem Cells in Diabetic Foot Ulcer Treatment: Clinical Effectiveness

Intriguing work from our friend and colleague Prof. Beata Rakowska and coworkers from Poland Although encouraging results of adipose-derived stem cell (ADSC) use in wound healing are available, the mechanism of action has been studied mainly in vitro and in animals. This work aimed to examine the safety and efficacy of allogenic ADSCs in human... Continue Reading →

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Use of Hyperspectral Imaging to Predict Healing of Diabetic Foot Ulceration #Diagnostics #Theragnostics #ActAgainstAmputation @ALPSlimb

This work by our colleagues from the Deaconess and Joslin constitutes another advance in the slow, steady march toward deriving an actionable value from hyperspectral imaging. Bottom line: Using oxyHb 50 as the cutof point to predict DFU complete healing, Visit 1 oxyHb measurement provided 85% sensitivity, 70% specificity, 50% positive predictive value and 93%... Continue Reading →

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