Tag: wound healing

“Spooky Action at a Distance”: The Most Comprehensive Review Yet of Physiologic Neuromodulation for Limb Preservation #ActAgainstAmputation #Neuromodulation #SpinalCordStimulation #CLTI @BurnsTrauma @KeckSchool_USC @ResearchatUSC @USC

Our new paper in Burns and Trauma presents the most comprehensive review yet of spooky action at a distance therapies for diabetic limb preservation — from spinal cord stimulation and splenic ultrasound to remote ischemic conditioning and tibial transport. Five modalities, three mechanistic pathways, one shared destination: tissue repair at a distance.

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From Foot to Fatality: The #DiabeticFootAttack Is Real, and It’s Worse Than You Think @alpslimb #ActAgainstAmputation

A new single-center study from the Netherlands quantifies the devastating outcomes of the diabetic foot attack: only 48.5% wound closure, 46% major amputation by 12 months, 26% one-year mortality, and 12-month amputation-free survival of just 39.7%. Time is tissue.

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25 Years of Plantar Pressure Research in #DiabeticFoot Ulcers: A Bibliometric Deep Dive @MDABORATORY #ActAgainstAmputation

A new bibliometric analysis from Wei and colleagues at Capital Medical University in Beijing maps 25 years (2000–2024) of global research on plantar pressure and diabetic foot ulcers — over 2,100 publications indexed in the Web of Science Core Collection. The findings tell a story that will feel familiar to many of us who have... Continue Reading →

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Control-Alt-Delete: Rebooting the Chronic Wound #ActAgainstAmputation #DFU #WoundHealing @ALPSLimb @KeckSchool_USC @USC_Vascular

Chronic wounds are biological computers stuck in a boot loop. Sharp debridement is Control-Alt-Delete — the histological reboot that converts a chronic wound back into an acute one. Only then can you run the apps.

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Vitamin D’s Long Arc from Ancient Remedy to Modern Wound Healing

Vitamin D has been medicine for millennia — we just didn't know it. A tour through its history, its biology, and what the evidence now says about its role in diabetic foot ulcer healing.

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Measuring what we Manage: Why the Mother of Modern Nursing is the Grandmother of Big-Time Data Viz

You'll often hear us saying "you can't manage what you can't measure", but for those of us in the trenches of limb salvage and wound healing, this isn't just a mantra—it is a moral imperative. And if we want to see the future of how we treat the "patient-in-place," we need to look back nearly... Continue Reading →

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Gene Therapy Emerges as a Potentially New Tool in Wound Healing for People with Vascular Disease: The LEGenD-1 Trial

Published today in Circulation: Cardiovascular Interventions, the LEGenD-1 trial represents a step toward a potential milestone in regenerative medicine and limb preservation. The study, titled “Anatomically Directed Lower Extremity Gene Therapy for Ulcer Healing: A Double-Blind, Randomized, Placebo-Controlled Study,” demonstrates that gene therapy can safely potentially accelerate wound healing in patients with chronic limb-threatening ischemia... Continue Reading →

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A Global Consensus on Diabetic Wound Management #ActAgainstAmputation

This open-access consensus (Advances in Wound Care, 2025) synthesizes practical, evidence-driven guidance for the bedside management of diabetic wounds—spanning pathophysiology, glycemic care, infection/biofilm control, vascular assessment and revascularization, offloading, surgery, pain, dressings, and emerging therapies. Contributors (acknowledged individually)• Henry C. Hsia• Elof Eriksson• Geoffrey C. Gurtner• Aristidis Veves• Osama Hamdy• David J. Margolis• David G.... Continue Reading →

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Boosting Healing: Could Vitamin D be a Significant, Inexpensive, Widely-available Adjunct in Treating Diabetic Foot Ulcers #ActAgainstAmputation #DFU #Nutrition

For millions living with diabetes, foot ulcers are more than a painful inconvenience—they’re a serious, often underestimated health threat. With sluggish healing and high infection risks, DFUs dramatically increase the likelihood of hospitalization and amputation. But a recent clinical trial points to a simple, well-known compound—vitamin D—as a powerful ally in the battle against DFUs.... Continue Reading →

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Serine, Stress, and Skin: A New Focus? @Cell_Metabolism #ActAgainstAmputation

A Nutrient-Driven Balancing Act: How Serine Tunes Stem Cell Fate in Skin Repair Novak et al., 2025, Cell Metabolism ⚖️ Serine, Stress, and Skin: A New Paradigm What if a single non-essential amino acid could pivot stem cells from regenerating hair to healing wounds? A striking new study from Elaine Fuchs’ group at Rockefeller University... Continue Reading →

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