A terrific review by Rome’s Serini and Calviello Long-chain Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) are widely recognized as powerful negative regulators of acute inflammation. However, the precise role exerted by these dietary compounds during the healing process is still largely unknown, and there is increasing interest in understanding their specific effects on the implicated […]Read More New Insights on the Effects of Dietary Omega‐3 Fatty Acids on Impaired Skin Healing in DFU and VLU #DiabeticFoot #Wound Healing
A great review from Queensland that should help put some of the confusing M1-M2 phenotype story into sharper relief. Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds Abstract: Macrophages play a prominent role in wound healing. In the early stages, they promote inflammation and remove pathogens, wound debris, and cells that […]Read More Mixed up Macrophages: M1/M2 Dysregulation in Diabetic Foot Ulcers
Great, provocative work by our colleagues Prof. Keith Harding and coworkers. Complete healing is problematic as an endpoint for evaluating interventions for wound healing. The great heterogeneity of wounds makes it difficult to match groups, and this is only possible with multivariate stratification and/or very large numbers of subjects. The substantial time taken for wounds […]Read More Measuring progress to healing: A challenge and an opportunity – The value of wound margin advancement
Is There an Association between Sleep Disorders and Diabetic Foot? A Scoping Review Abstract: Diabetic foot is associated with a low quality of life since physical disabilities, mood disturbances and psychological disorders are frequent. One of the most important biological processes to ensure quality of life is sleep. Sleep disorders can impair glycemic control in […]Read More Is There an Association Between Sleep Disorders and Diabetic Foot Ulcer Healing?
Diabetic foot ulcers are a growing problem and clinicians are limited by their reliance on conventional culture. Metagenomic sequencing technology provides an unparalleled viewpoint of the polymicrobial constituency of DFU. The microbiome techniques used to study the microbial constituency of DFU ma … — Read on pubmed.ncbi.nlm.nih.gov/34152440/ We are still in a bit of a […]Read More Metagenomics to Identify Pathogens in Diabetic Foot Ulcers and the Potential Impact for Clinical Care –
Research suggests a correlation between low vitamin D levels and hard-to-heal wounds. However, it is not clear if the relationship is causal or only correlational. There is also emerging evidence on the use of vitamin D supplementation for the treatment of hard-to-heal wounds. More research is neede … — Read on pubmed.ncbi.nlm.nih.gov/34120468Read More Correlation between vitamin D levels and hard-to-heal wounds: a systematic review – causal or correlational?
There is an urgent need for interventions that improve healing time, prevent amputations and recurrent ulceration in patients with diabetes-related foot wounds. In this randomised, open-label trial, participants were randomised to receive an application of non-cultured autologous skin cells (“spray- … — Read on pubmed.ncbi.nlm.nih.gov/34156758/ There was no difference in healing between active and control […]Read More Wound healing with “spray-on” autologous skin grafting (ReCell) compared with standard care in patients with large diabetes-related foot wounds: an open-label randomised controlled trial – PubMed
There are precious few small molecule (aka drug) solutions for wound healing. Perhaps this is one of an emerging trend. Impaired wound healing and ulcer complications are a leading cause of death in diabeticpatients. In this study, we report the design and synthesis of a cyclometalated iridium(III)metal complex 1a as a stabilizer of hypoxia-inducible factor-1α […]Read More A small molecule HIF-1α stabilizer that accelerates diabetic wound healing #smallmolecule @naturecomms
Fascinating and important review work from Yan and coworkers in this manuscript. Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers Abstract: Diabetes mellitus is one of the most widespread metabolic diseases in the world, and diabetic foot ulcer (DFU), as one of its chronic complications, not only causes a large amount of physiological and […]Read More Long, non-coding RNAs (lncRNA) in Diabetic Foot Ulcers: New Targets? New Paths?
Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing Efforts on this small molecule in wound healing are gaining speed. We at SALSA @USC couldn’t be more enthusiastic about desferrioxamine!Read More Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing