Microenvironment-Based Diabetic Foot Ulcer Nanomedicine #ActAgainstAmputation @ALPSlimb

An ambitious review from Huang and coworkers Diabetic foot ulcers (DFU), one of the most serious complications of diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, the DFU microenvironment is rather complicated and characterized by hyperglycemia, ischemia, hypoxia, hyperinflammation, and persistent infection. However, the current... Continue Reading →

Intraoperative 3D Printed Fat Graft Biodressing: Results of an initial series ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC @USC_vascular @ResearchatUSC @KeckSchool_USC @PRSjournal

This from our combined team. To our knowledge, this is the first such use of this type of technology in the USA. We will see if it or technologies like it have staying power. Autologous Minimally Manipulated Homologous Adipose Tissue (AMHAT) for Treatment of Nonhealing Diabetic Foot Ulcers David G. Armstrong, DPM, MD, PhD,* Steven G.... Continue Reading →

Nanofiber Aerogels with Precision Macrochannels and LL‐37‐Mimic Peptides Synergistically Promote Diabetic Wound Healing @JohnsonVJ17 @ALPSLimb #ActAgainstAmputation @TerasakiInst @kademh

Important work from our colleagues and collaborators Johnson John and coworkers at Terasaki. Fast healing of diabetic wounds remains a major clinical challenge. Herein, this study reports a strategy to combine nanofiber aerogels containing precision macrochannels and the LL-37-mimic peptide W379 for rapid diabetic wound healing. Nanofiber aerogels consisting of poly(glycolide-co-lactide) (PGLA 90:10)/gelatin and poly-p-dioxanone... Continue Reading →

Future Directions in Research in Transcriptomics in the Healing of Diabetic Foot Ulcers @alpslimb #ActAgainstAmputation #WoundHealing

Great work from our colleagues in Yale + Harvard Diabetic foot ulcers are a health crisis that affect millions of individuals worldwide. Current standard of care involves diligent wound care with adjunctive antibiotics and surgical debridement. However, despite this, the majority will still become infected and fail to heal. Recent efforts using bioengineered skin initially... Continue Reading →

The effect of inflammation management on pH, temperature, and bacterial burden #ActAgainstAmputation #WoundHealing

Important work from Derwin and coworkers in Zena Moore's group. The aim of this feasibility study was to investigate the impact of inflammation management on wound pH, temperature, and bacterial burden, using the principles of TIME and Wound Bed Preparation. A quantitative non-comparative, prospective, descriptive observational design. Following ethical approval, 26 participants with 27 wounds... Continue Reading →

Armstrong reports on early results from first-ever gene therapy in wound healing study at vascular biology symposium @USC @ResearchatUSC @USC_vascular

David G. Armstrong, Professor of Surgery and Director of the Southwestern Academic Limb Salvage Alliance (SALSA) at Keck School of Medicine of University of Southern California (USC), reported on the first results of a novel phase 2 study of gene therapy to heal wounds and reduce amputations in people with vascular disease at the International... Continue Reading →

Negative Pressure Wound Therapy Promotes Wound Healing by Inhibiting Inflammation in Diabetic Foot Wounds: A Role for NOD1 Receptor

Yet more insight into the mechanism of action of NPWT. From Wang and coworkers in the International Journal of Lower Extremity Wounds (IJLEW). Aims: Diabetic foot results in frequent amputation and quality-of-life reduction in diabetes population. These lesions are featured by a prolonged and exaggerated inflammation with a significant impairment in local bacterial invasion. Negative pressure... Continue Reading →

Two-Stage Gene Therapy (VEGF, HGF and ANG1 Plasmids) as Adjunctive Therapy in the Treatment of Critical Lower Limb Ischemia in Diabetic Foot Syndrome #ActAgainstAmputation #DiabeticFoot @ALPSlimb

It's superb work from our Polish colleagues. One of the most serious problems in people with diabetes is diabetic foot syndrome. Due to the peripheral location of atherosclerotic lesions in the arterial system of the lower extremities, endovascular treatment plays a dominant role. However, carrying out these procedures is not always possible and does not... Continue Reading →

Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions #Theragnostics #Diagnostics @CSHL @UnivMiami

A great perspective from Pastar and coworkers from our long-time friend Marjana Tomic-Canic's lab at University of Miami published in Cold Spring Harbor Perspectives in Biology. Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds with multifactorial etiologies that are associated... Continue Reading →

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