A small molecule HIF-1α stabilizer that accelerates diabetic wound healing #smallmolecule @naturecomms

There are precious few small molecule (aka drug) solutions for wound healing. Perhaps this is one of an emerging trend. Impaired wound healing and ulcer complications are a leading cause of death in diabeticpatients. In this study, we report the design and synthesis of a cyclometalated iridium(III)metal complex 1a as a stabilizer of hypoxia-inducible factor-1α […]

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Long, non-coding RNAs (lncRNA) in Diabetic Foot Ulcers: New Targets? New Paths?

Fascinating and important review work from Yan and coworkers in this manuscript. Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers Abstract: Diabetes mellitus is one of the most widespread metabolic diseases in the world, and diabetic foot ulcer (DFU), as one of its chronic complications, not only causes a large amount of physiological and […]

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Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing

Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing Efforts on this small molecule in wound healing are gaining speed. We at SALSA @USC couldn’t be more enthusiastic about desferrioxamine!

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The Role of Oxidative Stress and Antioxidants in Wound Healing @USC_Vascular @KeckMedUSC

This manuscript from our collaboration between Chongqing and USC Foot ulcers are one of the most common and severe complication of diabetes mellitus with significant resultant morbidity and mortality. Multiple factors impair wound healing include skin injury, diabetic neuropathy, ischemia, infection, inadequate glycemic control, poor nutritional status, and severe morbidity. It is currently believed that […]

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Pharmacotherapy for Diabetic Foot Ulcers- Topical and Systemic

A superb technical review from our SALSAmigos Dixon and Edmonds from King’s. Historically, there has been a scarcity of evidence-based topical therapy to hasten the healing of diabetic foot ulcers. But recently new evidence-based treatments have emerged from multicentre, randomised, controlled trials. This article highlights those trials, and describes the current pharmacological management of the […]

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Poor sleep and hypoxemia may be associated with longer wound healing and more frequent ulcer recurrence in remission

Fascinating work from Chen and coworkers. Perhaps something else we need to focus on that we often acknowledge but frequently neglect! STUDY OBJECTIVES: Sleep-disordered breathing (SDB) is prevalent and associated with increased risk of morbidity and mortality. However, whether SDB has an adverse impact on wound healing in patients with diabetic foot ulcers (DFUs) is […]

Read More Poor sleep and hypoxemia may be associated with longer wound healing and more frequent ulcer recurrence in remission

DNA sequencing to improve treatment of urinary infections: Are wounds next?

Fascinating technology from East Anglia. Obviously, we at SALSA see direct applications in wound healing.   Urinary tract infections could be treated more quickly and efficiently using a DNA sequencing device the size of a USB stick — according to research from the University of East Anglia.Researchers used a new device called MinION to perform […]

Read More DNA sequencing to improve treatment of urinary infections: Are wounds next?