Three Blinded Adjudicators: Minimizing bias in a diabetic foot ulcer clinical evaluation

This three blinded adjudicator model is one we've been using for several years in recent RCTs. Congrats to our amigos Paul Glat, Lisa Gould, Lael Pickett, and Doug Arm for putting it out there for publication and ultimately iteration. This specific analysis was derived from the HIFLO trial. Summary: The article discusses the steps taken... Continue Reading →

Allogenic Adipose-Derived Stem Cells in Diabetic Foot Ulcer Treatment: Clinical Effectiveness

Intriguing work from our friend and colleague Prof. Beata Rakowska and coworkers from Poland Although encouraging results of adipose-derived stem cell (ADSC) use in wound healing are available, the mechanism of action has been studied mainly in vitro and in animals. This work aimed to examine the safety and efficacy of allogenic ADSCs in human... Continue Reading →

Use of Hyperspectral Imaging to Predict Healing of Diabetic Foot Ulceration #Diagnostics #Theragnostics #ActAgainstAmputation @ALPSlimb

This work by our colleagues from the Deaconess and Joslin constitutes another advance in the slow, steady march toward deriving an actionable value from hyperspectral imaging. Bottom line: Using oxyHb 50 as the cutof point to predict DFU complete healing, Visit 1 oxyHb measurement provided 85% sensitivity, 70% specificity, 50% positive predictive value and 93%... Continue Reading →

Granulocyte‐macrophage colony‐stimulating factor: Conductor of the wound healing orchestra? ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC @USC_vascular @ResearchatUSC @KeckSchool_USC

Granulocyte-macrophage colony-stimulating factor: Conductor of the wound healing orchestra? This manuscript from our team led by Karim Ead Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein and is derived from both hemopoietic and nonhemopoietic sources which exert immunomodulatory properties. Various theories have been proposed to explain why some wounds become chronic and non-healing. Generalized suppression of... Continue Reading →

Effects of vildagliptin on wound healing and markers of inflammation in patients with type 2 diabetic foot ulcer: a prospective, randomized, double-blind, placebo-controlled, single-center study #ActAgainstAmputation @ALPSlimb

From our colleagues at James Cook University in Queensland, Australia. Introduction: Diabetic foot ulcers (DFU) are one of the leading long-term complications experienced by patients with diabetes. Dipeptidyl Peptidase 4 inhibitors (DPP4is) are a class of antihyperglycemic medications prescribed to patients with diabetes to manage glycaemic control. DPP4is may also have a beneficial effect on DFU... Continue Reading →

Microenvironment-Based Diabetic Foot Ulcer Nanomedicine #ActAgainstAmputation @ALPSlimb

An ambitious review from Huang and coworkers Diabetic foot ulcers (DFU), one of the most serious complications of diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, the DFU microenvironment is rather complicated and characterized by hyperglycemia, ischemia, hypoxia, hyperinflammation, and persistent infection. However, the current... Continue Reading →

Intraoperative 3D Printed Fat Graft Biodressing: Results of an initial series ActAgainstAmputation #DiabeticFoot @ALPSlimb @USC @USC_vascular @ResearchatUSC @KeckSchool_USC @PRSjournal

This from our combined team. To our knowledge, this is the first such use of this type of technology in the USA. We will see if it or technologies like it have staying power. Autologous Minimally Manipulated Homologous Adipose Tissue (AMHAT) for Treatment of Nonhealing Diabetic Foot Ulcers David G. Armstrong, DPM, MD, PhD,* Steven G.... Continue Reading →

Nanofiber Aerogels with Precision Macrochannels and LL‐37‐Mimic Peptides Synergistically Promote Diabetic Wound Healing @JohnsonVJ17 @ALPSLimb #ActAgainstAmputation @TerasakiInst @kademh

Important work from our colleagues and collaborators Johnson John and coworkers at Terasaki. Fast healing of diabetic wounds remains a major clinical challenge. Herein, this study reports a strategy to combine nanofiber aerogels containing precision macrochannels and the LL-37-mimic peptide W379 for rapid diabetic wound healing. Nanofiber aerogels consisting of poly(glycolide-co-lactide) (PGLA 90:10)/gelatin and poly-p-dioxanone... Continue Reading →

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