Tag: wound healing

Gene Therapy Emerges as a Potentially New Tool in Wound Healing for People with Vascular Disease: The LEGenD-1 Trial

Published today in Circulation: Cardiovascular Interventions, the LEGenD-1 trial represents a step toward a potential milestone in regenerative medicine and limb preservation. The study, titled “Anatomically Directed Lower Extremity Gene Therapy for Ulcer Healing: A Double-Blind, Randomized, Placebo-Controlled Study,” demonstrates that gene therapy can safely potentially accelerate wound healing in patients with chronic limb-threatening ischemia... Continue Reading →

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A Global Consensus on Diabetic Wound Management #ActAgainstAmputation

This open-access consensus (Advances in Wound Care, 2025) synthesizes practical, evidence-driven guidance for the bedside management of diabetic wounds—spanning pathophysiology, glycemic care, infection/biofilm control, vascular assessment and revascularization, offloading, surgery, pain, dressings, and emerging therapies. Contributors (acknowledged individually)• Henry C. Hsia• Elof Eriksson• Geoffrey C. Gurtner• Aristidis Veves• Osama Hamdy• David J. Margolis• David G.... Continue Reading →

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Boosting Healing: Could Vitamin D be a Significant, Inexpensive, Widely-available Adjunct in Treating Diabetic Foot Ulcers #ActAgainstAmputation #DFU #Nutrition

For millions living with diabetes, foot ulcers are more than a painful inconvenience—they’re a serious, often underestimated health threat. With sluggish healing and high infection risks, DFUs dramatically increase the likelihood of hospitalization and amputation. But a recent clinical trial points to a simple, well-known compound—vitamin D—as a powerful ally in the battle against DFUs.... Continue Reading →

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Serine, Stress, and Skin: A New Focus? @Cell_Metabolism #ActAgainstAmputation

A Nutrient-Driven Balancing Act: How Serine Tunes Stem Cell Fate in Skin Repair Novak et al., 2025, Cell Metabolism ⚖️ Serine, Stress, and Skin: A New Paradigm What if a single non-essential amino acid could pivot stem cells from regenerating hair to healing wounds? A striking new study from Elaine Fuchs’ group at Rockefeller University... Continue Reading →

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What’s Your CONUT? The Hidden Nutritional Score That Could Be Affecting Wound Healing #ActAgainstAmputation #Nutrition #Diet #woundhealing

If you’ve ever had a routine blood test, you’ve probably seen numbers for cholesterol, hemoglobin, or even zinc. But have you ever checked your CONUT score? No, it’s not a secret menu item at Shake Shack—it’s actually a critical measure of nutritional health that may be the missing link in healing diabetic foot ulcers (DFUs). What... Continue Reading →

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Prof. David G. Armstrong Delivers Powerful Keynote Address at the Palais des Congrès in Paris on Wound Healing, Drawing a Connection Between Pre-Olympic Los Angeles Fires and Post-Olympic Paris’ Notre Dame

For Immediate Release Paris, France – January 2025 – Prof. David G. Armstrong, a global leader in diabetic limb preservation and Professor of Surgery at the University of Southern California, delivered an inspiring and deeply impactful keynote address to a full house at the Journées Cicatrisations 2025, held at the renowned Palais des Congrès in Paris.... Continue Reading →

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The Larger the Wound, the Greater the Nutritional Challenge: Insights from Recent Research

Screenshot Recent research by Skórka et al. (2024) highlights an essential yet often overlooked aspect of wound healing: the larger the wound, the greater the risk of nutritional deficiency. This finding underscores the critical need for integrating nutritional assessment and intervention into the care of patients with chronic wounds, such as those caused by diabetic foot... Continue Reading →

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Further Exploring Tibial Periosteal Distraction as a Adjunct to Healing Diabetic Foot Ulcers

Diabetic foot ulcers (DFUs) represent one of the most significant challenges in managing diabetes-related complications. Affecting millions worldwide, DFUs lead to substantial morbidity, healthcare costs, and a heightened risk of amputation. While traditional therapies like debridement, offloading, and vascular interventions have their place, innovative solutions are crucial to improve outcomes. A recent study by Yuan... Continue Reading →

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The “Relay Race” to Healing: Insights from a Spatiotemporal Roadmap of Human Skin Wound Healing #WoundHealing

In the intricate dance of healing, our bodies engage in a biological relay race, passing the baton of recovery from one cellular team to the next. A groundbreaking study, “Spatiotemporal Single-Cell Roadmap of Human Skin Wound Healing,” published in Cell Stem Cell(2024), maps this race at the single-cell level, offering unparalleled insights into the dynamic processes of human... Continue Reading →

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The Impact of Angiographic Pedal Circulation Status on Wound Healing in Chronic Limb-Threatening Ischemia After Bypass Surgery #ActAgainstAmputation #WoundHealing #WIFI

Miyake K, Kikuchi S, Uchida D, Doita T, Miyagawa S, Azuma N Understanding Pedal Circulation’s Role in CLTI Wound Healing In chronic limb-threatening ischemia (CLTI), achieving complete wound healing is critical for reducing morbidity and improving patient outcomes. Although the Global Limb Anatomic Staging System (GLASS) provides a robust framework for assessing CLTI severity, its... Continue Reading →

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