Novel Glucose-Lowering Agents That Benefit the Diabetic Foot: Icing on the Cake #ActAgainstAmputation

As the global burden of diabetes continues to climb, so too does the impact of its most feared complicationsโ€”including diabetic foot ulcers (DFUs), infections, and amputations. While tight glycemic control has long been a cornerstone of diabetic foot prevention, emerging therapies are now offering benefits that go beyond glucose reduction. In our newly accepted paper... Continue Reading →

Exploring the Risks of SGLT2i vs. DPP-4i as Add-On Therapies in Diabetes Care #Amputation #PAD #CLTI #Stent #DiabetesCare

A new study published in Diabetes Care sheds light on the comparative risks of peripheral artery disease (PAD)-related surgical eventsโ€”such as amputations, stent placements, or vascular surgeriesโ€”between two classes of diabetes medications: sodium-glucose cotransporter 2 inhibitors (SGLT2i) and dipeptidyl peptidase 4 inhibitors (DPP-4i). Conducted among U.S. veterans, this retrospective cohort study analyzed over 150,000 episodes of medication... Continue Reading →

Effects of vildagliptin on wound healing and markers of inflammation in patients with type 2 diabetic foot ulcer: a prospective, randomized, double-blind, placebo-controlled, single-center study #ActAgainstAmputation @ALPSlimb

From our colleagues at James Cook University in Queensland, Australia. Introduction: Diabetic foot ulcers (DFU) are one of the leading long-term complications experienced by patients with diabetes. Dipeptidyl Peptidase 4 inhibitors (DPP4is) are a class of antihyperglycemic medications prescribed to patients with diabetes to manage glycaemic control. DPP4is may also have a beneficial effect on DFU... Continue Reading →

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