Tag: etiology

When Stress Doesn’t Tell the Whole Story: Walking Speed, Pre-Ulcers, and the Path to Prevention #ActAgainstAmputation #DiabeticFootUlcer

For decades, clinicians and researchers have sought a simple, reliable biomechanical predictor of diabetic foot ulceration. Peak plantar pressure has been the standard metric, but its predictive value has always been modest. A newer, more holistic measure—cumulative plantar tissue stress (CPTS)—was thought to offer better predictive power by integrating multiple factors: plantar pressure, time spent... Continue Reading →

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Journal of the American Medical Association: Diabetic Foot Ulcers @JAMA_Current #ActAgainstAmputation #DiabeticFoot

From JAMA Armstrong, Tan, Boulton, and Bus, JAMA. 2023;330(1):62-75. doi:10.1001/jama.2023.10578 In diabetic foot disease, tissue loss,ischemia, and infection frequentlyoverlap. However, one is frequentlymore dominant than the other atdifferent times in the life cycle of anacute-on-chronic event. Here, theamount of tissue loss, ischemia, andfoot infection can be ordinally gradedto help predict outcome and assist incommunicating a plan... Continue Reading →

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Mechanisms of diabetic foot ulceration

Mechanisms of diabetic foot ulceration: A review Here's the summary of this manuscript by Deng and coworkers: • Diabetic foot ulcers (DFUs) are a serious complication of diabetes, with complex pathogenic factors. • Previous studies focused on diabetic peripheral vascular disease, neuropathy, and wound infections. • Researchers are now studying immune cells, endothelial cells, keratinocytes,... Continue Reading →

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An Enigma Wrapped in Edema: Charcot Neuropathic OsteoArthropathy @DiabetesCareADA @ALPSlimb #ActAgainstAmputation

Important work from Jeffcoate and Game in Diabetes Care continues the slow, steady march toward measuring, managing, and understanding what I like to call an enigma wrapped in edema. The Charcot Foot Reflects a Response to Injury That Is Critically Distorted by Preexisting Nerve Damage: An Imperfect Storm William Jeffcoate and Fran Game It has... Continue Reading →

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