Mechanisms of diabetic foot ulceration: A review
Here’s the summary of this manuscript by Deng and coworkers:
• Diabetic foot ulcers (DFUs) are a serious complication of diabetes, with complex pathogenic factors.
• Previous studies focused on diabetic peripheral vascular disease, neuropathy, and wound infections.
• Researchers are now studying immune cells, endothelial cells, keratinocytes, and fibroblasts to understand the role of wound healing.
• Molecular signaling pathways play a crucial role in the healing of DFUs, and epigenetics has become a sought-after trend in DFU treatment.
• This review focuses on four aspects of DFU pathogenesis: physiological and pathological mechanisms, cellular mechanisms, molecular signaling pathway mechanisms, and epigenetics.
• The authors suggest that understanding these mechanisms will lead to the development of effective products for treating DFUs.
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