Mechanisms of diabetic foot ulceration

Mechanisms of diabetic foot ulceration: A review

Here’s the summary of this manuscript by Deng and coworkers:

• Diabetic foot ulcers (DFUs) are a serious complication of diabetes, with complex pathogenic factors.

• Previous studies focused on diabetic peripheral vascular disease, neuropathy, and wound infections.

• Researchers are now studying immune cells, endothelial cells, keratinocytes, and fibroblasts to understand the role of wound healing.

• Molecular signaling pathways play a crucial role in the healing of DFUs, and epigenetics has become a sought-after trend in DFU treatment.

• This review focuses on four aspects of DFU pathogenesis: physiological and pathological mechanisms, cellular mechanisms, molecular signaling pathway mechanisms, and epigenetics.

• The authors suggest that understanding these mechanisms will lead to the development of effective products for treating DFUs.