Antibiotics and the Redox Paradox: Can Levofloxacin Actually Stall Wound Healing? #GeneExpression #AntimicrobialStewardship #ActAgainstAmputation #FriendlyFire @limbsandlungs @bradspellberg

For years, weโ€™ve operated under a simple clinical assumption: if a diabetic foot ulcer (DFU) is infected, we reach for the antibioticsโ€”often broad-spectrum heavy hitters like levofloxacin. But new molecular evidence suggests that while we are busy fighting bacteria, we may be unintentionally collateral-damaging the woundโ€™s own healing machinery. A recent study published in Scientific... Continue Reading →

Mechanisms of diabetic foot ulceration

Mechanisms of diabetic foot ulceration: A review Here's the summary of this manuscript by Deng and coworkers: โ€ข Diabetic foot ulcers (DFUs) are a serious complication of diabetes, with complex pathogenic factors. โ€ข Previous studies focused on diabetic peripheral vascular disease, neuropathy, and wound infections. โ€ข Researchers are now studying immune cells, endothelial cells, keratinocytes,... Continue Reading →

Bioinformatic Analysis Reveals Hub Immune-Related Genes of Diabetic Foot Ulcers #ActAgainstAmputation

This from Rong and coworkers Summary Points: Diabetic foot ulcer (DFU) is a complex and devastating complication of diabetes mellitus that are usually stagnant in the inflammatory phase.However, oral wound healing, which is characterized by a rapid and scarless healing process, is regarded an ideal model of wound healing.Thus, we performed a comprehensive bioinformatics analysis... Continue Reading →

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