On diabetic foot, wound healing, amputation prevention, and the merger of consumer tech with medical devices
An email from Ben Lipsky brings new biomarker data — IL-17, IL-12p70, HMGB1, IL-8, CRP — that may be the strongest case yet for splitting "moderate" and "severe" diabetic foot infections in the IDSA and WIfI classification.
Senneville and Lipsky return with a measured rejoinder in Clinical Infectious Diseases (April 2026), arguing that the Lagrand trial shows the absence of evidence of superiority — not definitive equivalence — between ulcer-bed and bone biopsy for guiding antibiotic therapy in diabetic foot osteomyelitis.
Inspired by much recent discussion as well as a blog post from 13 years ago, here is a manuscript just published. After further discussion with Prof. Ben Lipsky, he raises the interesting idea of calling some of these "infection in situ" just like cancer in situ.
https://player.captivate.fm/episode/46e6e398-323e-4acc-b272-a6c43efb1382 Episode 98 of the Febrile podcast 98: StAR: Diabetes-related Foot Infections Episode 98 • 22nd April 2024 • Febrile • Sara Dong Shownotes This StAR episode features the CID State-of-the-Art Review on evaluation and management of diabetes-related foot infections. Our guest stars this episode are: Dr. Meghan Brennan (ID physician at University of Wisconsin) Dr. Marcos Schechter (ID physician... Continue Reading →
The manuscript titled "Evaluation and Management of Diabetes-related Foot Infections," authored by Nicolas W. Cortes-Penfield, David G. Armstrong, Meghan B. Brennan, Maya Fayfman, Jonathan H. Ryder, Tze-Woei Tan, and Marcos C. Schechter, has been recognized as one of the five best publications in the IDSA's flagship journal, Clinical Infectious Diseases, for 2023. This significant accomplishment... Continue Reading →
In a landscape where clinicians are increasingly exploring novel approaches to diabetic foot ulcer management, a recent study led by Brian Schmidt from the University of Michigan—co-authored by Rodica Pop-Busui, president of the American Diabetes Association, Keith Kaye, of the Robert Wood Johnson Medical School and Dr. David G. Armstrong, a leading podiatric surgeon and... Continue Reading →
Here is a popular table from our recent Infectious Diseases Society of America Diabetic Foot Infection Guidelines discussing suggested durations of therapy for soft tissue and bone infections.
