Tag: Microbiome

The Wound Microbiome: From Passive Passenger to Therapeutic Target #ActAgainstAmputation #Microbiome #Diagnostics

For years, we’ve looked at chronic wounds through a relatively narrow lens—clean them, debride them, and hope the host's biology eventually kicks into gear. But as our understanding of the wound microbiome deepens, it’s becoming clear that these microbial communities aren't just "there"—they are active architects of the healing (or non-healing) environment. A recent review... Continue Reading →

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Unraveling the Role of Gut Microbiota and Metabolites in Diabetic Chronic Wounds #WoundEcology #ActAgainstAmputation #Microbiome

Screenshot Diabetic wounds present considerable physical and economic challenges due to impaired healing and persistent inflammation, further complicated by intricate microbe-host interactions. Diabetic foot ulcers (DFUs), in particular, represent a critical clinical issue. The human gut harbors an extensive microbial ecosystem composed of intestinal flora and their metabolic byproducts, which play pivotal roles in systemic... Continue Reading →

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Exploring the Future of Diabetic Foot Infection Diagnostics @IDSAinfo #Microbiology #DiabeticFoot #InfectiousDiseases

Diabetic foot infections are a significant concern, often leading to severe complications, including amputation. Recent advancements in molecular microbiology have shown promise in improving our understanding and management of these infections. A recent review by Sande et al. (2023) critically evaluates the use of next-generation molecular assays, such as metagenomics and metatranscriptomics, in diagnosing and... Continue Reading →

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Enhancing Diabetic Wound Healing: A little help from Alcaligenes faecalis? #Microbiome #ActAgainstAmputation

In the ongoing quest to improve diabetic wound healing, a recent study published in Science Advances sheds light on an innovative approach involving the bacterium Alcaligenes faecalis. This Gram-negative bacterium, often found in chronic wounds but rarely causing infections, has demonstrated significant potential in promoting wound healing by correcting the aberrant expression of matrix metalloproteinases... Continue Reading →

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Toward non-invasive collection methods for sampling the microbiome of diabetic foot ulcers #Infection #Diabetes #ActAgainstAmputation #DiabeticFoot

Strong work from Bradbury and coworkers in the IWJ. Bottom line: Both swabs and tissues appeared to perform well for 16s sampling and sequencing. Identifying the microbiome within chronic diabetic foot ulcers is essential if effective antimicrobial therapies are to be administered. Using culture and 16S rRNA gene sequencing, the aim of this study was... Continue Reading →

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Metagenomics of Diabetic Foot Ulcer Undergoing Treatment with Total Contact Casting (TCC) @USC_vascular @USC @ALPSlimb @CosmosID

This initial look into what may be a routine survey of metagenomic data from week to week. Led by FASMA's Adam Isaac, CosmosID's (National Science Foundation Director Emerita) Prof. Rita Colwell and our team. Objective: Diabetic foot ulcers (DFUs) are characterised by the presence of many microbes, some of which may not be identified by traditional... Continue Reading →

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Gut Microbiota and Complications of Type-2 Diabetes

Gut Microbiota and Complications of Type-2 Diabetes The gut microbiota has been linked to the emergence of obesity, metabolic syndrome and the onset of type 2 diabetes through decreased glucose tolerance and insulin resistance. Uncontrolled diabetes can lead to serious health consequences such as impaired kidney function, blindness, stroke, myocardial infarction and lower limb amputation.... Continue Reading →

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A Clinical Study to Evaluate Autofluorescence Imaging of Diabetic Foot Ulcers Using a Novel Artificial Intelligence Enabled Noninvasive Device #ActAgainstAmputation #DiabeticFoot

A Clinical Study to Evaluate Autofluorescence Imaging of Diabetic Foot Ulcers Using a Novel Artificial Intelligence Enabled Noninvasive Device Great work from our long-time friend and colleague Vijay Viswanathan and coworkers pushing diagnostics and theragnostics forward. Fluorescence of Bacteria Diabetic foot ulcers, with worldwide prevalence ranging from 12%-25%, are an important cause of nontraumatic lower... Continue Reading →

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Using a BonE BiOPsy (BeBoP) to determine the causative agent in persons with diabetes and foot osteomyelitis: study protocol for a multicentre, randomised controlled trial @bradspellberg @limbsandlungs @alpslimb #ActAgainstAmputation

We look forward to this study and it's resultant findings from our good friend and colleague Edgar Peters and coworkers Diabetic foot osteomyelitis (DFO) poses a major disease burden. It can generally be treated with long-term antibacterial therapy. International guidelines recommend to base antibacterial therapy choices on percutaneous bone biopsy culture, while in practice, therapy... Continue Reading →

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Metagenomics to Identify Pathogens in Diabetic Foot Ulcers and the Potential Impact for Clinical Care –

Diabetic foot ulcers are a growing problem and clinicians are limited by their reliance on conventional culture. Metagenomic sequencing technology provides an unparalleled viewpoint of the polymicrobial constituency of DFU. The microbiome techniques used to study the microbial constituency of DFU ma … — Read on pubmed.ncbi.nlm.nih.gov/34152440/ We are still in a bit of a... Continue Reading →

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