Toward non-invasive collection methods for sampling the microbiome of diabetic foot ulcers #Infection #Diabetes #ActAgainstAmputation #DiabeticFoot

Strong work from Bradbury and coworkers in the IWJ. Bottom line: Both swabs and tissues appeared to perform well for 16s sampling and sequencing. Identifying the microbiome within chronic diabetic foot ulcers is essential if effective antimicrobial therapies are to be administered. Using culture and 16S rRNA gene sequencing, the aim of this study was... Continue Reading →

Metagenomics of Diabetic Foot Ulcer Undergoing Treatment with Total Contact Casting (TCC) @USC_vascular @USC @ALPSlimb @CosmosID

This initial look into what may be a routine survey of metagenomic data from week to week. Led by FASMA's Adam Isaac, CosmosID's (National Science Foundation Director Emerita) Prof. Rita Colwell and our team. Objective: Diabetic foot ulcers (DFUs) are characterised by the presence of many microbes, some of which may not be identified by traditional... Continue Reading →

Gut Microbiota and Complications of Type-2 Diabetes

Gut Microbiota and Complications of Type-2 Diabetes The gut microbiota has been linked to the emergence of obesity, metabolic syndrome and the onset of type 2 diabetes through decreased glucose tolerance and insulin resistance. Uncontrolled diabetes can lead to serious health consequences such as impaired kidney function, blindness, stroke, myocardial infarction and lower limb amputation.... Continue Reading →

A Clinical Study to Evaluate Autofluorescence Imaging of Diabetic Foot Ulcers Using a Novel Artificial Intelligence Enabled Noninvasive Device #ActAgainstAmputation #DiabeticFoot

A Clinical Study to Evaluate Autofluorescence Imaging of Diabetic Foot Ulcers Using a Novel Artificial Intelligence Enabled Noninvasive Device Great work from our long-time friend and colleague Vijay Viswanathan and coworkers pushing diagnostics and theragnostics forward. Fluorescence of Bacteria Diabetic foot ulcers, with worldwide prevalence ranging from 12%-25%, are an important cause of nontraumatic lower... Continue Reading →

Using a BonE BiOPsy (BeBoP) to determine the causative agent in persons with diabetes and foot osteomyelitis: study protocol for a multicentre, randomised controlled trial @bradspellberg @limbsandlungs @alpslimb #ActAgainstAmputation

We look forward to this study and it's resultant findings from our good friend and colleague Edgar Peters and coworkers Diabetic foot osteomyelitis (DFO) poses a major disease burden. It can generally be treated with long-term antibacterial therapy. International guidelines recommend to base antibacterial therapy choices on percutaneous bone biopsy culture, while in practice, therapy... Continue Reading →

Metagenomics to Identify Pathogens in Diabetic Foot Ulcers and the Potential Impact for Clinical Care –

Diabetic foot ulcers are a growing problem and clinicians are limited by their reliance on conventional culture. Metagenomic sequencing technology provides an unparalleled viewpoint of the polymicrobial constituency of DFU. The microbiome techniques used to study the microbial constituency of DFU ma … — Read on We are still in a bit of a... Continue Reading →

High-Resolution Spectral Analysis Accurately Identifies the Bacterial Signature in Infected Chronic Foot Ulcers in People With Diabetes

Will we soon see more visual diagnostics for wounds? Congratulations to our colleagues in Melbourne for these intriguing data. Diabetic foot infections are a major cause of hospitalization, and delayed treatment can lead to numerous complications. The aim of this research was to investigate high-resolution spectroscopy of the wound center and periwound area for real-time... Continue Reading →

Can probiotics improve healing of diabetic foot ulcers? Results from a randomized controlled trial

This fascinating work from Mohseni and coworkers seems to support the contention that our bacterial overlords have more power over us than we'd like to let on. Perhaps we should further consider submitting? Patients with a diabetic foot ulcer who received probiotic supplementation for 12 weeks experienced faster wound healing coupled with an improved glycemic... Continue Reading →

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