Antibiotics and the Redox Paradox: Can Levofloxacin Actually Stall Wound Healing? #GeneExpression #AntimicrobialStewardship #ActAgainstAmputation #FriendlyFire @limbsandlungs @bradspellberg

For years, we’ve operated under a simple clinical assumption: if a diabetic foot ulcer (DFU) is infected, we reach for the antibiotics—often broad-spectrum heavy hitters like levofloxacin. But new molecular evidence suggests that while we are busy fighting bacteria, we may be unintentionally collateral-damaging the wound’s own healing machinery. A recent study published in Scientific... Continue Reading →

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Tiny Robots, Big Gains: Is Nanobotics the Future of Wound Repair and Limb Preservation? #ActAgainstAmputation

Tiny Robots, Big Gains: Is Nanobotics the Future of Limb Salvage? The "holy grail" of wound healing has always been a treatment that doesn't just sit on the wound but actively works within it. Traditional dressings—even the fancy ones—are largely passive barriers. But a groundbreaking review recently published in the International Journal of Nanomedicine suggests... Continue Reading →

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Limb Preservation Pioneer David G. Armstrong Becomes First Podiatric Surgeon to Surpass 10,000 Research Citations in a Single Year #ActAgainstAmputation @ALPSLimb @USC_Vascular @KeckSchool_USC @USC

FOR IMMEDIATE RELEASE LOS ANGELES, CA — Dr. David G. Armstrong, Distinguished Professor of Surgery and Neurological Surgery at the Keck School of Medicine of USC, has reached a historic bibliometric milestone. According to the latest data from Google Scholar, Dr. Armstrong has become the first podiatric surgeon in the history of the specialty to... Continue Reading →

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The “Toe, Flow, and Go” Paradigm: Moving Beyond the Sedentary Prescription #ActAgainstAmputation #DiabeticFoot #Diabetes

For decades, the standard response to a diabetic foot ulcer has been to shut everything down. We focus so intently on offloading that we often inadvertently prescribe a total sedentary lifestyle. But as our colleagues at the University of Michigan point out in their recent review, we need to shift the narrative toward "Toe, Flow,... Continue Reading →

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The 10-Year Warning: Early Red Flags for Limb Loss in a Nationwide Study #ActAgainstAmputation

We often view lower extremity amputation (LEA) as the culmination of a rapid clinical decline, but new data suggests the warning signs are flashing nearly a decade in advance. A large 10-year national study out of Denmark recently identified specific healthcare and sociodemographic markers that can predict amputation risk long before the situation becomes "limb... Continue Reading →

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Digging Deep vs. Scratching the Surface: Is the “Gold Standard” for DFO Biopsies Losing its Shine? #ActAgainstAmputation #Infection #Osteomyelitis

Friends, we have some serious dogma-busting data to discuss today. For as long as most of us have been in the limb salvage game, the percutaneous bone biopsy has been preached as the absolute "Gold Standard" for guiding antibiotic therapy in Diabetic Foot Osteomyelitis (DFO). The logic was sound: if you want to know what’s... Continue Reading →

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The Invisible Barrier: Are We Actually Beating Biofilm or Just Guessing? #ActAgainstAmputation #WoundHealing #CIBL #ChronicWounds @ResearchAtUSC @KeckSchool_USC @USC_Vascular

Biofilms are the silent drivers of chronicity in diabetic foot ulcers (DFUs). We talk about them constantly. We blame them for stalled healing. But when you peel back the layers of current literature, how much hard clinical evidence do we actually have that our interventions are destroying them? In our latest systematic review, published in... Continue Reading →

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The “Comfort Paradox”: Why Feeling Good Might Be Bad for the Diabetic Foot #ActAgainstAmputation @ALPSlimb @KeckSchool_USC #Shoes #Neuropathy

We often talk about the "Princess and the Pea" in our line of work, but for our patients with neuropathy, the story is reversed. The pea—or the rock, or the seam—is there, but the princess simply cannot feel it. A fascinating new narrative review just published in J. Clin. Med. by Carral-Sota and colleagues drives... Continue Reading →

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Prof. David G. Armstrong Delivers Powerful Keynote on Multidisciplinary Care and Digital Health at International Wound Congress in Turkey #ActAgainstAmputation @usc_vascular

FOR IMMEDIATE RELEASE ANTALYA, TURKEY – David G. Armstrong, DPM, MD, PhD, Distinguished Professor of Surgery and Neurological Surgery at the University of Southern California (USC), has been selected to deliver the opening keynote address at the 19th National & 7th International Wound Congress. The event, held at the Titanic Mardan Palace from December 4–7,... Continue Reading →

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Can We Actually “Regrow” Sensation? The Launch of PDN-Sensory #DiabeticFoot #Neuromodulation #ActAgainstAmputation #Neuropathy

For years, we’ve treated Painful Diabetic Neuropathy (PDN) largely by trying to turn down the volume on the pain. While relief is critical, the "holy grail" has always been something more: stopping the damage or, dare we dream, reversing it. We have just published the design for a new multicenter randomized controlled trial (RCT) in... Continue Reading →

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