An Enigma Wrapped in Edema: Rethinking Charcot Arthropathy #ActAgainstAmputation #DiabeticFoot

Please see our manuscript here.

Winston Churchill famously described Russia as ‘a riddle,
wrapped in a mystery, inside an enigma’ in a 1939 broadcast .
Indeed, two centuries after the birth of Jean-­ Martin Charcot, the
condition that bears his name remains, as Churchill might say,
an enigma wrapped in oedema—an inflammatory mystery too
often misread or misdiagnosed as mundane. Charcot neuroar-
thropathy (CNO) in people with diabetes is not rare. It is under-recognised,
underdiagnosed and undertreated. And thanks to
a growing coalition of clinicians, researchers and now national
funders, that may be about to change

Armstrong DG, Shin L, “An Enigma Wrapped in Edema: Rethinking Charcot Neuroarthropathy in Diabetes on JM Charcot’s 200th Birthday,” International Wound Journal, DOI:10.1111/iwj.70832, 2026

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