A large study led by William V. Padula, PhD, from the University of Southern California, in collaboration with Swetha Ramanathan, PhD, MPH, Benjamin G. Cohen, PhD, MPH, Gerald Rogan, MD, and David G. Armstrong, DPM, MD, PhD, has unveiled the enhanced efficacy of placental allografts in treating diabetic lower extremity ulcers (DLEUs) and venous leg ulcers (VLUs) in U.S. Medicare beneficiaries. This study, involving a retrospective analysis of a vast cohort, firmly positions viable cryopreserved and lyopreserved placental membrane (vCPM and vLPM) allografts as game-changers in wound care, significantly reducing one-year mortality, recurrence rates, and adverse outcomes compared to standard care. The study was published in the Journal of Wound Care.
Key Findings That Are Changing the Face of Wound Care:
- The study analyzed data from 333,632 patients with diabetic lower extremity ulcers (DLEUs) and 122,012 patients with venous leg ulcers (VLUs), bringing to light the stark improvements in treatment outcomes with the use of placental allografts.
- In DLEU cases treated with vLPM, there was a notable distribution across the U.S. with a significant percentage of patients treated in outpatient settings (93.4%), indicating the practical applicability of this treatment modality in diverse healthcare environments.
- The comorbidity profiles of patients, including conditions such as myocardial infarction and peripheral vascular disease, underline the complex care needs of this patient population and the imperative for innovative treatment options.
- For VLUs treated with vCPM and vLPM, the data echoed similar trends, with a majority of treatments occurring in outpatient settings (98.7%) and a broad geographic distribution of cases. This underscores the widespread potential and adaptability of placental allograft treatments across different healthcare landscapes.
This study included authors from Stage Analytics, Suwanee, GA, Rogan Consulting, Sacramento, CA, and the Southwestern Academic Limb Salvage Alliance (SALSA) at the Keck School of Medicine of USC. It not only highlights the potential effectiveness of placental allografts but also emphasizes the critical role of advanced treatment modalities in improving patient outcomes in wound care.
As we move forward, the integration of such innovative therapies promises a brighter future for individuals suffering from chronic wounds, offering hope for reduced morbidity and a pathway towards healing and recovery.
Join the Conversation and Spread Awareness:
- Hashtags: #WoundCareInnovation #DiabeticUlcers #VenousLegUlcers #AdvancedWoundCare #HealthcareResearch #ActAgainstAmputation
Dr. William V Padula, Dr. Swetha Ramanathan, Dr. Benjamin G. Cohen, Dr. Gerald Rogan, and Dr. David G. Armstrong.Comparative Effectiveness of Placental Allografts in the Treatment of Diabetic Lower Extremity Ulcers and Venous Leg Ulcers in U.S. Medicare Beneficiaries: a retrospective observational cohort study using real-world evidence .Advances in Wound Care.ahead of print http://doi.org/10.1089/wound.2023.0143
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