In the Know with Toe and Flow: A Multidisciplinary Approach to Limb Preservation #ActAgainstAmputation @ALPSlimb

Every 20 seconds, someone around the world faces the devastating reality of losing a limb due to complications from diabetes, peripheral artery disease, trauma, and other critical conditions. This global challenge not only affects individual lives but also imposes significant economic and societal burdens. Why is limb preservation such a complex task? Often, healthcare providers... Continue Reading →

Repair, Regeneration, and Replacementโ€”Redux: A Look into the Future of Medicine @USC @CalTech @UCSF @Rancho_ResearchI @UCLA

How Do We Delay Decay? In 2012, the Repair, Regeneration, and Replacement Revisited lecture posed a fundamental question: How do we delay the inevitable decline of the human body? Now, 13 years later, that question is more relevant than ever. With AI-driven health technologies, regenerative medicine, and bioengineered solutions, we stand at the edge of a new medical revolution. We revisit... Continue Reading →

Bone Biopsy or Deep Tissue Culture? The Battle for Diagnosing Diabetic Foot Osteomyelitis #ActAgainstAmputation

Screenshot Bone Biopsy vs. Deep Tissue Culture: The Smackdown for Diagnosing Diabetic Foot Osteomyelitis When it comes to diabetic foot osteomyelitis (DFO), thereโ€™s one big question: How do we diagnose it accurately? For years, bone biopsy has been considered the heavyweight champion of diagnosisโ€”but itโ€™s invasive, requires surgical skill, and isnโ€™t always feasible. Meanwhile, deep tissue cultures offer a quicker, less... Continue Reading →

Whatโ€™s Your CONUT? The Hidden Nutritional Score That Could Be Affecting Wound Healing #ActAgainstAmputation #Nutrition #Diet #woundhealing

If youโ€™ve ever had a routine blood test, youโ€™ve probably seen numbers for cholesterol, hemoglobin, or even zinc. But have you ever checked your CONUT score? No, itโ€™s not a secret menu item at Shake Shackโ€”itโ€™s actually a critical measure of nutritional health that may be the missing link in healing diabetic foot ulcers (DFUs). What... Continue Reading →

How four steps can save two legs, worldwide #ActAgainstAmputation @alpslimb

This from our Keck physician page for more info, see Building a Scalable Limb Preservation Program: 4 Steps to Success A Keck Medicine of USC podiatric surgeon outlines actionable steps for optimizing diabetic foot ulcer care. Each year, diabetic foot ulcers affect nearly 18.6 million people globally, contributing to more than 1.6 million amputations annually. These... Continue Reading →

Diabetes-Related Extremity Amputation Depression and Distress (DREADD): A Multimethod Study #ActAgainstAmputation @alpslimb @usc_vascular

Diabetes mellitus poses numerous health challenges, among which diabetic foot ulcers (DFUs) are notably prevalent. Approximately 34% of individuals with type 2 diabetes in the United States will develop a DFU during their lifetime. Alarmingly, about 18% of these cases progress to lower-limb amputations.   While the physical ramifications of such amputations are well-documented, the psychological... Continue Reading →

Unlocking the Potential of Pedal Acceleration Time in Peripheral Artery Disease Diagnosis: The Latest Data #ActAgainstAmputation #Diagnostics #CLTI

Peripheral artery disease (PAD) is a widespread but often underdiagnosed condition affecting millions worldwide. Traditional diagnostic tools like the ankle-brachial index (ABI) and toe-brachial index (TBI) have limitations, particularly in patients with diabetes or medial arterial calcification. A newly published study in the European Journal of Vascular & Endovascular Surgery by Sommerset et al. introduces pedal acceleration time... Continue Reading →

Pioneering Amputation Prevention: A Feature on Dr. David Armstrong #ActAgainstAmputation

The latest feature in Living With Amplitude highlights the groundbreaking work of Dr. David G. Armstrong in the field of diabetic limb preservation. As a global leader in this space, Dr. Armstrongโ€™s mission is clear: to end preventable amputations through innovation, research, and interdisciplinary collaboration. Read the full article here. The article explores Dr. Armstrongโ€™s pioneering role... Continue Reading →

@USC Prof. David G. Armstrong Makes History as First Podiatric Surgeon to Deliver Medicine Grand Rounds at Mayo Clinic Rochester @ALPSlimb #ActAgainstAmputation

ROCHESTER, MN โ€“ February 25, 2025 โ€“ Professor David G. Armstrong, DPM, MD, PhD, renowned expert in limb preservation and diabetic foot care, has become the first podiatric surgeon to deliver Medicine Grand Rounds at the prestigious Mayo Clinic in Rochester. Prof. Armstrongโ€™s historic presentation, titled "Looking Back to Look Forward: Tissue Repair, Wound Healing,... Continue Reading →

A First RCT for Calcium Sulfate Pellets in Diabetic Foot Osteomyelitis Treatment: The BIG D-FOOT Study #ActAgainstAmputation

Diabetic foot osteomyelitis (DFO) is a formidable challenge in limb preservation, often leading to major amputations and significant morbidity. Systemic antibiotic treatments are fraught with limitationsโ€”poor tissue penetration due to peripheral arterial disease, risks of systemic toxicity, and antibiotic resistance. But what if we could deliver antibiotics exactly where they are needed most? A groundbreaking randomized controlled... Continue Reading →

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