Observed impact of skin substitutes in lower extremity diabetic ulcers: lessons from the Medicare Database (2015-2018)

Summary: This study from our combined team suggests that use of advanced therapies for treatment of lower extremity wounds was associated with significant reductions in major and minor amputation, ED use, and hospital readmission compared with similarly matched patients not receiving advanced therapy. Objective: To evaluate large propensity-matched cohorts to assess outcomes in patients receiving advanced […]

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Immediate Effects of Weight-Bearing Calf Stretching on Ankle Dorsiflexion Range of Motion and Plantar Pressure During Gait in Patients with Diabetes Mellitus

Terrific work by our colleagues from Kobe, Tokyo, Nara and Osaka, respectively! High plantar pressure is a risk factor for diabetic foot ulcers, and it is known that restriction of ankle dorsiflexion range of motion (ROM) causes high plantar pressure. Stretching is a non-invasive and general means to improve ROM; however, the effect of stretching […]

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Impact of repeated remote ischemic conditioning on diabetic foot ulcers

This open label, single-arm study from Regulski and coworkers continues the data supporting potential use of this safe, simple intervention Patients with a diabetic foot ulcer (DFU) suffer disabilities and are at increased riskfor lower extremity amputation. Current standard of care includes debridement, topi-cal antibiotics, and weight off-loading—still resulting in low rates of healing. Previoussmall-scale […]

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Stratification of Microvascular Disease Severity in the Foot Using Spatial Frequency Domain Imaging

Work from our combined UofA and USC team with our colleagues at Modulim. Samuel Jett 1, Mallory R Thompson 2, Shubhangi Awasthi 2, David J Cuccia 1, Tze-Woei Tan 2, David G Armstrong 3, Amaan Mazhar 1, Craig C Weinkauf 2 Background: Microvascular disease (MVD) describes systemic changes in the small vessels (~100 um diameter) that impair tissue oxygenation and perfusion. MVD is a common but poorly monitored complication of diabetes. […]

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Materials and Cytokines in the Healing of Diabetic Foot Ulcers

Important deep dive from Kim and coworkers published in Advanced Therapeutics Diabetes affects an increasing number of patients, and is associated with sustained and chronic inflammation. Complications arising from diabetes, including hypoxia, neuropathy, hyperglycemia, and ischemia that contribute to a delayed and reduced healing response result in chronic slow healing wounds. Here, key differences in […]

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Nerve damage in diabetes

This series from the Guardian and BMJ reviews practical best practices for care of people with diabetes, including care of the feet.——- To see this story with its related links on the guardian.co.uk site, go to http://www.guardian.co.uk/lifeandstyle/besttreatments/diabetes-type-1-nerve-damage-in-diabetes Nerve damage in diabetesWednesday January 7 2009BMJ Group Over time, high levels of glucose (sugar) in your blood […]

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MU Researcher Suggests Diabetics with Previous Foot Ulcer Complications may be able to Participate in Walking Program

http://insciences.org/article.php?article_id=1348 Dosing activity like we dose a drug The late Paul Brand, the now legendary medical director of theHansen’s Disease center in Carville, Louisiana, was quoted as saying“a wound will heat up before it breaks down”. He was, of course,correct in this assertion. This led many (including me) to assumesomething of a linear conceptual relationship […]

Read More MU Researcher Suggests Diabetics with Previous Foot Ulcer Complications may be able to Participate in Walking Program